Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Kristina M. Adams Waldorf · UNIVERSITY OF WASHINGTON · 2022 · $849,396 — Project Summary Pregnant women are highly vulnerable to influenza A virus (IAV) and are at increased risk for maternal death, preterm birth and stillbirth. Universal influenza vaccines (UFV) are thought to be possible if conserved regions of influenza virus are targeted and appropriate immune respon…
Kathryn Marie Jones · BAYLOR COLLEGE OF MEDICINE · 2022 · $783,532 — Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection Abstract: Chagas disease, caused by infection with the vector borne intracellular protozoal parasite Trypanosoma cruzi, affects approximately 6.5 million people worldwide. Chronic infection with T. cruz…
William T Jackson · UNIVERSITY OF MARYLAND BALTIMORE · 2022 · $386,250 — Enteroviruses are among the most severe causes of human disease, and recent outbreaks of emerging enteroviruses such as types D68 and 71 have highlighted the need to understand more about these pathogens. Our comparative studies of poliovirus (PV), coxsackievirus B3, and now EV-D68 have shown many c…
Matthew R Vogt · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $653,847 — Project Summary Manifestations of enterovirus infections are variable, with several severe illnesses such as meningitis, acute flaccid myelitis (AFM), myocarditis, and neonatal sepsis. Poliovirus vaccines are near perfect at preventing severe illness by generating strong, circulating antibody respon…
Emma H Wilson · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2022 · $8,000 — PROJECT SUMMARY: The organizers of the 16th International Congress on Toxoplasmosis and Toxoplasma gondii Research request support for this meeting, which will occur in May 2022, after a 1 year pandemic-re- lated delay. Toxoplasma gondii is a ubiquitous, protozoan parasite that is transmitted throug…
Umesh C Sharma · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2022 · $279,125 — Immunomodulation of Galectin-3 to Prevent Radiation-Induced Myocardial Fibrogenesis This application addresses the scientific goals of FOA-PA-19-112. More than half of life-threatening thoracic cancers are treated with repeated doses of ionizing radiation. Unfortunately, the pro-inflammatory and pr…
Kristina M. Adams Waldorf · UNIVERSITY OF WASHINGTON · 2021 · $864,027 — Project Summary Pregnant women are highly vulnerable to influenza A virus (IAV) and are at increased risk for maternal death, preterm birth and stillbirth. Universal influenza vaccines (UFV) are thought to be possible if conserved regions of influenza virus are targeted and appropriate immune respon…
Umesh C Sharma · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2021 · $279,125 — Immunomodulation of Galectin-3 to Prevent Radiation-Induced Myocardial Fibrogenesis This application addresses the scientific goals of FOA-PA-19-112. More than half of life-threatening thoracic cancers are treated with repeated doses of ionizing radiation. Unfortunately, the pro-inflammatory and pr…
Joseph Scaduto · CMTX BIOTECH, INC. · 2021 · $315,000 — PROJECT SUMMARY/ABSTRACT CMTx Biotech is a drug development company working to rescue and repurpose a proprietary clinical-stage drug candidate, incyclinide (CMT-3 / COL-3), for the treatment of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suffering from Co…
George A. Belov · UNIV OF MARYLAND, COLLEGE PARK · 2021 · $228,233 — Multiple enteroviruses are associated with life-threatening and economically important diseases, yet the licensed vaccines are only available against poliovirus and enterovirus 71. The antigenic diversity of enterovirus capsids restricts the protective efficacy of vaccines only to antigenically very…
Saraswati Pokharel · ROSWELL PARK CANCER INSTITUTE CORP · 2021 · $209,275 — Early Detection and Immunomodulation of PD-1 Inhibitor-Induced Cardiotoxicity Abstract The recent discovery of immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 blockers, has revolutionized the management of advanced stage malignancies including lung cancers, melanoma, head and neck, and…
William T Jackson · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $386,250 — Enteroviruses are among the most severe causes of human disease, and recent outbreaks of emerging enteroviruses such as types D68 and 71 have highlighted the need to understand more about these pathogens. Our comparative studies of poliovirus (PV), coxsackievirus B3, and now EV-D68 have shown many c…
William T Jackson · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $386,250 — Enteroviruses are among the most severe causes of human disease, and recent outbreaks of emerging enteroviruses such as types D68 and 71 have highlighted the need to understand more about these pathogens. Our comparative studies of poliovirus (PV), coxsackievirus B3, and now EV-D68 have shown many c…
REX L CHISHOLM · NORTHWESTERN UNIVERSITY AT CHICAGO · 2020 · $384,018 — PROJECT SUMMARY Since early 2020, COVID-19 disease spread rapidly across the US and will likely be sustained or recur periodically until an effective vaccine or prophylactic treatment is developed. The pandemic will have a large impact on the conduct of the next phase of eMERGE, including recruitmen…
George A. Belov · UNIV OF MARYLAND, COLLEGE PARK · 2020 · $189,608 — Multiple enteroviruses are associated with life-threatening and economically important diseases, yet the licensed vaccines are only available against poliovirus and enterovirus 71. The antigenic diversity of enterovirus capsids restricts the protective efficacy of vaccines only to antigenically very…
Saraswati Pokharel · ROSWELL PARK CANCER INSTITUTE CORP · 2020 · $258,790 — Early Detection and Immunomodulation of PD-1 Inhibitor-Induced Cardiotoxicity Abstract The recent discovery of immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 blockers, has revolutionized the management of advanced stage malignancies including lung cancers, melanoma, head and neck, and…
William T Jackson · UNIVERSITY OF MARYLAND BALTIMORE · 2019 · $386,250 — Enteroviruses are among the most severe causes of human disease, and recent outbreaks of emerging enteroviruses such as types D68 and 71 have highlighted the need to understand more about these pathogens. Our comparative studies of poliovirus (PV), coxsackievirus B3, and now EV-D68 have shown many c…
RSV Vaccination in Adults: Work Group Interpretations Michael Melgar, MD Amadea Britton, MD, SMAdvisory Committee on Immunization PracticesOctober 24, 2024National Center for Immunization and Respiratory Diseases 2•Summarize Work Group interpretations of: - - -Current RSV vaccine safety surveillance data and the balance of estimated benefits and risks associated with protein subunit* RSV vaccination in adults ages 60 years and older Coadministration of RSV vaccines with other adult vaccines…
Recommendations from the Combined Immunization Schedule Work Group for the 2025 Immunization Schedules for Children/Adolescents and Adults Sybil Cineas, MD, FAAP , FACP (ACIP Combined Immunization WG Chair) Nanda Issa, MD ( CDC Co -Lead ) Patricia Wodi, MD (CDC acting Co -Lead) ACIP Meeting October 24, 2024National Center for Immunization and Respiratory Diseases The Combined Immunization Schedules WG: •Updates the immunization schedules annually -Child and adolescent schedule (for ages…
Recommendations from the Combined Immunization Schedule Work Group for the 2025 Immunization Schedules for Children/Adolescents and Adults Sybil Cineas, MD, FAAP , FACP (ACIP Combined Immunization WG Chair) Nanda Issa, MD (CDC Co -Lead ) Patricia Wodi, MD (CDC acting Co -Lead) ACIP Meeting October 24, 2024National Center for Immunization and Respiratory Diseases Dr. Nanda Issa2025 Update to Child and Adolescent Immunization Schedule Age 18 years or younger How to Use the Immunization…