Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
WEN-YUAN E HSIEH · UNIVERSITY OF COLORADO DENVER · 2022 · $621,860 — PROJECT SUMMARY Emergence of the highly transmissible SARS-CoV-2 B.1.617.2 (Delta) variant and return to in-person learning is rapidly increasing the COVID-19 disease incidence and transmission rate in children. Therefore, it is critical to protect younger children. Toward this goal, ongoing COVID-1…
LUKAS K TAMM · UNIVERSITY OF VIRGINIA · 2022 · $562,219 — PROJECT SUMMARY Membrane fusion, mediated by viral spike glycoproteins, is a key process in the infection cycle of all enveloped human and animal viruses. The overall goal of this project is to understand the molecular mechanisms of Ebola and human immunodeficiency virus entry by membrane fusion, by…
Inyoul Lee · OHIO STATE UNIVERSITY · 2022 · $878,950 — Abstract The World Health Organization has recognized a global pandemic of novel coronavirus pneumonia (COVID-19) from exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronaviruses (CoVs) are membrane-enveloped positive-sense, single-stranded RNA viruses decorated with …
Kristina L Bailey · OMAHA VA MEDICAL CENTER · 2022 — COVID-19 is now a global pandemic requiring a rapid and concerted response from the scientific and medical community. Based upon recent epidemiology derived only months earlier from the earliest affected countries, the pathogenesis of the SARS-CoV-2 virus and clinical outcomes from COVID-19 are far …
Carey Lynn Shive · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2022 — The global pandemic of SARS-CoV-2 is placing urgent demands on health care workers and researchers. Between April 3rd and May 1st global cases of COVID19 nearly tripled from approximately 1 million to over 3 million. With the possibility of a reemergence of SARS-CoV-2 in the fall, rapid specific ant…
Jonathan Kyle Pokorski · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $197,500 — Summary The rapid development, distribution and administration of a COVID-19 vaccine to the global population is the most effective approach to quell this pandemic and future reoccurrence. Vaccination must occur broadly both in well-resourced and resource-poor areas of the world to be most effective…
NORMAN R HARRIS · LOUISIANA STATE UNIV HSC SHREVEPORT · 2022 · $365,000 — Approximately 32-44% of the adult US population has hypertension, with one of the many complications being hypertensive retinopathy. In one study, the prevalence of retinopathy was found to be 85% amongst those with severe hypertension, and 25% for those with mild hypertension. Retinal consequences …
DWAYNE W GODWIN · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2022 · $429,825 — PROJECT SUMMARY Alcohol withdrawal (WD) produces a range of dangerous clinical symptoms, including intense seizures. Hyperexcitability underlying seizures is produced by an array of intrinsic membrane properties that are disrupted by ethanol (EtOH). Prior work has demonstrated that chronic EtOH expo…
CLAIRE L MOORE · TUFTS UNIVERSITY BOSTON · 2022 · $206,250 — Determining the role of alternative mRNA polyadenylation in SARS-Cov-2 replication and the host innate immune response SARS-CoV-2 infection has caused the COVID-19 pandemic, and understanding the molecular mechanisms leading to its pathophysiology is a top biomedical priority. In spite of intense re…
Declan McCole · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2022 · $378,549 — SUMMARY/ABSTRACT The global coronavirus disease 2019 (COVID-19) pandemic has affected over 70 million individuals in 220 countries (www.who.int). A major clinical confounder of COVID-19 is the lack of knowledge of host factors that promote susceptibility to SARS-CoV-2 infection and more severe gastr…
Milen Kirilov · INGENIOUS TARGETING LABORATORY, INC. · 2022 · $998,985 — Project Summary Genetically-modified mouse models have proven to be essential for the production of antibody-related biological drugs (biologics). To date, the majority of biologics originate from mouse models, and small animal models are used not only to generate the antibodies, but also as a platf…
Wayne A. Marasco · DANA-FARBER CANCER INST · 2022 · $876,907 — Project Summary The emergence of the novel human betacoronavirus SARS-CoV2 in Wuhan, China in 2019 has rapidly evolved into a worldwide pandemic. Over a 100 million people have been infected and there have been several million deaths. There is also great disparity in the manner in which COVID-19 ill…
MARK ROBERTS LOONEY · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $623,280 — Project Summary/Abstract The acute respiratory distress syndrome (ARDS) was first formally described in 1967, but it has likely been the predominant cause of death in pandemic viral infections for centuries. Now, the world is at grips with a new pandemic from SARS-CoV-2, or COVID-19, which has infec…
PINGNIAN HE · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2022 · $324,720 — A. Provide supporting data showing that diabetic MPs contribute to the increases in the propagation of the virus compared to non-diabetic MP. A1. Demonstrate higher number of cellular internalizations of S-protein-bound DB MPs than that of S-protein-bound normal MPs. Experiments will be conducted in…
Hua Linda Cai · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $155,866 — ABSTRACT The central focus of this Administrative Supplement application to is to identify detailed molecular mechanisms of estrogen-dependent sex difference in COVID-19 to enable development of novel therapeutics that are in urgent need to control the pandemic. The outbreak of coronavirus disease 2…
Mohammed Bouziane · SUNOMIX THERAPEUTICS · 2022 · $252,010 — SUMMARY Over the last 25 months humanity has been confronting COVID-19 pandemic caused by the new Corona Virus 2 (SARS-CoV-2) infection. Mutations and deletions often occur in the genome of SARS-CoV-2 (predominantly in the Spike protein) resulting in more transmissible and pathogenic “variants of co…
GILL DIAMOND · UNIVERSITY OF MISSISSIPPI MED CTR · 2022 · $822,036 — Abstract Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a life-threatening illness with multi-system involvement in a subset of infected individuals. Oral and nasopharyngeal (NP) epithelial cells express the SARS-CoV-2 receptor…
Dan H. Barouch · FRED HUTCHINSON CANCER CENTER · 2022 · $9,754,127 — FOA: PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements Activity Code/Award: UM1/A1068614-15 (parent award) ------------------------------------------------------------------------------------ Project Abstract This proposal outlines the scientific agenda for the …
Peter B. Gilbert · FRED HUTCHINSON CANCER CENTER · 2022 · $439,437 — Project Abstract This proposal outlines the scientific agenda for the COVID-19 Prevention Network (CoVPN) Vaccines Leadership Operations Center (LOC) for continuing implementation of the first COVID-19 vaccine efficacy trial “A Phase 3, Randomized, Stratified, Observer-Blind, Placebo-Controlled Stud…
Kiesha Wilson · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2022 · $100,000 — PROJECT SUMMARY/ABSTRACT The virus, SARS-CoV-2 has caused COVID-19 and claimed the lives of over 240,000 Americans and 1,270,000 people worldwide. Severe cases of the disease leads to Acute Respiratory Distress Syndrome (ARDS), sepsis and can be fatal due to pulmonary inflammation and destruction of…