Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
Eliver Ghosn · EMORY UNIVERSITY · 2022 · $232,232 — Project Summary Mounting an effective antibody response against SARS-CoV-2 is key to fight off the infection. However, not all antibodies produced against the virus are protective. Recent studies show that high titers of immunoglobulin G (IgG) against the SARS-CoV-2 Spike (S) protein during natural…
Robert Tarran · ELDEC PHARMACEUTICALS, INC. · 2022 · $300,000 — PROJECT SUMMARY COVID-19 is caused by inhalation of the latest coronavirus (CoV) SARS-CoV-2 into the lungs, and airway epithelia are particularly susceptible to uptake this virus. Extensive evidence indicates that angiotensin converting enzyme 2 (ACE2) binds to the S1 subunit of the SARS-CoV-2 Spik…
John YJ Shyy · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $683,289 — Project Summary Vascular endothelial cell (EC) metabolism is essential for functional endothelium, and maladapted energy use severely affects EC health. AMP-activated protein kinase (AMPK) is a key regulator of cellular energy status and homeostatic function. Our preliminary studies showed that ener…
Haichao Wang · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2022 · $418,750 — PROJECT SUMMARY Microbial infections annually claim hundreds of thousands of victims in the U.S. alone, but its complex pathogenesis is still poorly understood. Our seminal discovery of HMGB1 as a late mediator of lethal endotoxemia (Science, 1999, Cited >4,000 times) has fueled continuous search fo…
Daniel Kulp · WISTAR INSTITUTE · 2022 · $228,788 — Project Summary This revised application was originally responding to the Emergency Award ‘Rapid Investigation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)’ submitted through PAR-20-177. However, we are submitting the revised application, up…
Margaret M Stratton · UNIVERSITY OF MASSACHUSETTS AMHERST · 2022 · $312,941 — PROJECT SUMMARY How does a memory outlast the lifetime of the molecule that encodes it? More than two decades ago, Francis Crick had the foresight to speculate that perhaps a multimeric protein could serve as a molecular memory by sharing its activation state with newly synthesized proteins through …
Renren Wen · VERSITI BLOOD HEALTH, INC. · 2022 · $659,871 — Abstract COVID-19 severity/lethality is associated with a dysfunctional inflammatory immune response and a hyper- engagement of pathways driving hemostasis and thrombosis, but the link between the two manifestations is not understood. Compared to patients with mild symptoms, severe COVID-19 patients…
Jim Rotolo · SAPIENCE THERAPEUTICS, INC. · 2022 · $288,178 — ABSTRACT The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is a serious threat to global public health, necessitating the rapid development of safe and effective medical countermeasures. SARS-CoV-2 pathogenicity requires a series of protein-protein interactions (PPI) involving the virus’ S prot…
Rebecca Michelle DuBois · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2022 · $31,284 — PROJECT SUMMARY Human astroviruses (HAstV) are a leading cause of viral diarrhea in children. Divergent HAstV strains are associated with fatal human encephalitis. Currently, no vaccines or antiviral therapies exist for HAstV infections. Our goal is to identify sites of vulnerability (Achilles' heel…
Diana Carolina Vanegas-Gamboa · CLEMSON UNIVERSITY · 2022 · $426,004 — Project Summary The devastation caused by emerging pathogens with fast transmission capacity, such as SARS-CoV-2, has demonstrated the importance of preparedness for future viral outbreaks; this includes the ability for fast deployment of in-situ testing tools and epidemiological surveillance with h…
Dan H. Barouch · BETH ISRAEL DEACONESS MEDICAL CENTER · 2022 · $725,409 — ABSTRACT The development of a SARS-CoV-2 vaccine may be critical to ending the COVID-19 pandemic. However, a critical gap in knowledge is the lack of understanding of correlates of SARS-CoV-2 immunity in humans. Our preliminary data suggest that antibodies correlate with protection following vaccina…
Samuel Matthew Young · UNIVERSITY OF IOWA · 2022 · $154,500 — Project Summary/Abstract Synapses are the fundamental unit of information transfer in the central nervous system (CNS) and are composed a highly complex molecular machinery that tightly regulates synaptic transmission and neuronal circuit output. A multitude of combinations of synaptic proteins and …
GARY B RUVKUN · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $431,960 — Project Summary/Abstract: Our discovery that the NGLY1/PNG-1 deglycosylation enzyme mediates the protein editing of N- glycosylated asparagines to aspartic acid of the SKN-1A transcription factor to increase proteasomal capacity is highly relevant to protein aggregation diseases, such as Alzheimer’s…
Hsien Wei YEH · UNIVERSITY OF WASHINGTON · 2022 · $80,225 — úú PROJECT SUMMARY/ABSTRACT Delivering diagnostic services at the point-of-care (POC) can improve the quality of healthcare in clinics, in emergency settings, or at home, which can potentially ease hospitals’ burden, for instance, during the COVID- 19 pandemic. Precision and personalized medicine re…
Ivan Zanoni · BOSTON CHILDREN'S HOSPITAL · 2022 · $751,928 — PROJECT SUMMARY Vaccines represent a highly effective public health measure to protect individuals from infectious diseases. Many vaccines work by inducing antigen-specific antibodies that neutralize the pathogen or its products and promote their clearance. Vaccines based on protein antigens usually…
RONALD N HARTY · FOX CHASE CHEMICAL DIVERSITY CENTER, INC · 2022 · $306,500 — The ultimate goal of this Phase I application is to discover and develop host-oriented small molecule compounds targeting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 is a novel coronavirus driving the current global pandemic of severe respiratory syndrome in hu…
Samarjit Das · JOHNS HOPKINS UNIVERSITY · 2022 · $500,000 — Abstract This supplement is in response to Funding Opportunity Announcement Number PA-20-272 Administrative Supplements to Existing NIH Grants and Cooperative Agreements. The supplement application is in response to the RADx-rad announcement on the opportunity of additional resources and funding sup…
David Margulies · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $51,958 — We have successfully engineered and produced a number of SARS-CoV-2 proteins, subunits, and single domain antibodies directed against the RBD. These purified proteins have provided the materials for obtaining high resolution crystal structures of four of these sybodies in complex with the Spike rece…
Mitchell Ho · DIVISION OF BASIC SCIENCES - NCI · 2022 · $45,270 — During the pandemic, Dr Ho has evaluated the challenges for developing antibody therapeutics targeting SARS-Cov-2 and wrote a review/perspective article [Ho Antibody Therapeutics 2020; PMID: 32566896]. SARS-CoV-2 gains entry to human cells through its spike (S) protein binding to angi…
Joseph Rodriguez · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2022 · $300,295 — Viruses use host components for their entire life cycle, from transcription and RNA processing of viral components to export and reinfection of new cells. ACE2 is an estrogen responsive cell receptor used by COVID19 to dock and enter host cells. TMPRSS2 is also an estrogen and androgen responsive …