NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Carey Lynn Shive · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · 2021 — The global pandemic of SARS-CoV-2 is placing urgent demands on health care workers and researchers. Between April 3rd and May 1st global cases of COVID19 nearly tripled from approximately 1 million to over 3 million. With the possibility of a reemergence of SARS-CoV-2 in the fall, rapid specific ant…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Susan Daniel · CORNELL UNIVERSITY · 2021 · $439,686 — Project Summary / Abstract Enveloped viruses access their host cells by binding to receptors on the plasma membrane and then undergoing fusion with the host membrane. Both binding and fusion are mediated by a specific viral “spike” protein that is typically primed for fusion activation by proteolyti…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Patricia Bea Keady · AEROSOL DEVICES, INC. · 2021 · $262,802 — As the current COVID-19 pandemic has demonstrated, aerosolized pathogens such as SARS-CoV-2 can spread explosively if not quickly detected. Early detection of these airborne pathogens can help control out- breaks, particularly within vulnerable populations in densely populated spaces including assis…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Jianfa Bai · KANSAS STATE UNIVERSITY · 2021 · $69,358 — Project Summary: SARS-CoV-2 is a major human respiratory pathogen that can cause COVID-19, a disease with symptoms similar to those caused by Influenza A (Flu A) and Influenza B (Flu B) viruses. A few major SARS-CoV-2 variants of concern (VOC) have been identified and associated with increased trans…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Radislav A Potyrailo · GENERAL ELECTRIC GLOBAL RESEARCH CTR · 2021 · $581,785 — PROJECT SUMMARY/ABSTRACT Available tools for detection of SARS-CoV-2 virus require extensive sample preparation and/or expensive lab- based equipment to obtain accurate results. The objective in this proposal is to build a touch-screen sensor array to directly capture, detect, and identify model SAR…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Thomas M McIntyre · CLEVELAND CLINIC LERNER COM-CWRU · 2021 · $572,341 — Hypertension, for unknown reasons, is a primary co-morbidity risk factor for poor COVID-19 outcomes. SARS- Cov-2 breaches the lung blood-air barrier to spread among organs inducing endothelial cell dysfunction and multi-organ thromboembolism. ACE2 is the high affinity receptor for SARS-Cov-2 with TM…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
TOMAS KIRCHHAUSEN · WASHINGTON UNIVERSITY · 2021 · $766,721 — The long term goal of this study is to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), enters cells and how to block that process through the use of therapeutics. Like other enveloped viruses, SARS-CoV-2 cell entry…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2021 · $194,118 — Administrative Supplement for Equipment - GM122917 Margaret A. Titus, PI Abstract of Parent Project Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and i…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Erica Ollmann Saphire · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2021 · $1,903,653 — Abstract SARS-CoV-2 rapidly emerged and spread throughout the globe to infect millions of people. The SARS-CoV-2 spike protein is the primary target of the immune response and thus most vaccine development efforts used the spike protein as an immunogen to elicit protective antibodies. However, as SA…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Michael-Christopher Keogh · EPICYPHER, INC. · 2021 · $1,024,792 — PROJECT SUMMARY Alterations in histone post-translational modifications (PTMs) are associated with diverse human pathologies. The ability to quantitatively assess these PTMs in healthy and diseased cells is essential to accelerate the development of drugs or diagnostics targeting epigenetic regulat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Rebecca Penrose Wilkes · PURDUE UNIVERSITY · 2021 · $77,500 — Project Summary SARS-CoV-2, the viral cause of COVID-19, has infected at least 94 pet cats in the United States, based on confirmed cases by the USDA. Many infections in cats are asymptomatic, and there are only a few ongoing surveillance studies in companion animals, so the number of cases in cats …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Savita Pahwa · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2021 · $153,500 — This Competitive Revision application for 2019 Novel Coronavirus research is related to the current grant Immune Dysfunction in HIV+ Opioid Users (DA051202) which is investigating influenza vaccine responses in people with HIV (PWH) who have opioid use disorder (OUD). The premise for the funded gran…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Luis J Montaner · WISTAR INSTITUTE · 2021 · $156,933 — SUMMARY The administration of effective anti- SARS-CoV-2 vaccines capable of eliciting a protective immune response in a large proportion of the population is a major public heath priority in combating Coronavirus disease 2019 (COVID-19). Our studies indicates that the functionality of soluble antib…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
SEBLE G KASSAYE · GEORGETOWN UNIVERSITY · 2021 · $35,088 — ABSTRACT MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV- infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, how…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Robert Turner Schooley · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $169,785 — Since the emergence of SARS CoV-2 in China in the fall of 2019, nearly 200 million cases of COVID-19 have been reported globally; over 4 million of these individuals have died. In the US, the virus has been responsible for over 600,000 deaths. Despite a good understanding of non-pharmaceutical inter…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Lanying Du · GEORGIA STATE UNIVERSITY · 2021 · $554,964 — Abstract Traditional strategies of vaccine development suffer from long-term and costly manufacture, and as a result, often fail to respond rapidly to newly emerging and reemerging infectious diseases. By contrast, messenger RNA (mRNA) is rising as a new technology platform to develop vaccines “on d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Wayne A. Marasco · DANA-FARBER CANCER INST · 2021 · $903,360 — Project Summary The emergence of the novel human betacoronavirus SARS-CoV2 in Wuhan, China in 2019 has rapidly evolved into a worldwide pandemic. Over a 100 million people have been infected and there have been several million deaths. There is also great disparity in the manner in which COVID-19 ill…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Joe H. Simmons · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2021 · $499,948 — Project Summary Recent successes using nanoparticles encapsulating mRNA payload for COVID-19 vaccination have energized the field of exosomes as novel vaccine agents. Exosomes (40-180nm), extracellular vesicles of the size of a virus and shed by all cells, are actively studied in viral biology. The …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Priyamvada Acharya · DUKE UNIVERSITY · 2021 · $704,939 — Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1 A glycan shield covers the HIV-1 envelope (Env) limiting antibody access to broadly neutralizing antibody (bnAb) epitopes. 2G12 had for long been the only example of a HIV-1 bnAb that interacts solely with…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Lanying Du · GEORGIA STATE UNIVERSITY · 2021 · $728,965 — Project Summary Viral subunit vaccines are safe and convenient, but generally suffer low efficacy. Our overall hypothesis is that an intrinsic limitation is associated with subunit vaccine designs in which artificially exposed surfaces of subunit vaccines contain epitopes unfavorable for vaccine eff…