Combined archive search across FBI Vault, SPLC, PHMPT, ACIP, NIH grants, the Federal Writers' Project, and other collections we've ingested.
JOHN ALTMAN · EMORY UNIVERSITY · 2021 · $856,666 — The NIH Tetramer Core Facility (TCF) distributes high quality reagents for detection of innate T cell and classical CD4 and CD8 T cell populations. This Facility also conducts R&D to produce new reagents and improve existing tetramer technologies. The TCF is producing MHC class I and class II tetram…
JOHN ALTMAN · EMORY UNIVERSITY · 2021 · $200,000 — The NIH Tetramer Core Facility (TCF) distributes high quality reagents for detection of innate T cell and classical CD4 and CD8 T cell populations. This Facility also conducts R&D to produce new reagents and improve existing tetramer technologies. The TCF is producing MHC class I and class II tetram…
Kui Kiu Chan · CYRUS BIOTECHNOLOGY, INC. · 2021 · $160,584 — ABSTRACT The spike protein (S) of SARS coronavirus 2, the pathogen responsible for COVID-19, binds angiotensin- converting enzyme 2 (ACE2) as an entry receptor, triggering conformational changes in S that drive fusion of the viral envelope and host cell membrane. Infection is inhibited by neutraliz…
GARY B RUVKUN · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $344,400 — Project Summary/Abstract: C. elegans surveils the mitochondrion for deficits and couples to an endocrine system of detoxification, innate immunity, and longevity control. This coupling of immunity and detoxification pathways to lifespan regulation has been observed in mice as well. Our analysis of i…
SUBHRA MOHAPATRA · JAMES A. HALEY VA MEDICAL CENTER · 2021 — COVID-19 super pandemic is still suffering from the lack of a vaccine or infection control measures and the lack of any treatments against this new virus. One of the unique features of SARS-CoV-2 is that it has an R0=2.2 (the ability of an infected patient to spread the disease) vs R0=1 for SARS-CoV…
TIMOTHY A HAYSTEAD · EYDIS BIO, INC. · 2021 · $309,288 — PROJECT SUMMARY/ABSTRACT The recent pandemic of novel coronavirus, COVID-19, has had a devastating effect on the health and well-being of individuals across the globe, including over 3.1 million confirmed infected so far, and a monumental impact on global healthcare systems and economies at large. I…
Carl W White · UNIVERSITY OF COLORADO DENVER · 2021 · $182,367 — PROJECT SUMMARY In the COVID-19 pandemic, >1.5 million Americans have become ill, and over 100,000 have died. So far, medically underserved populations are more than twice as likely to die or develop critical illness relative to their proportion in the population. Current and former smokers are also…
VINEET D MENACHERY · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $497,886 — Abstract The coronavirus (CoV) spike protein is a key viral determinant responsible for receptor binding and fusion/entry. The spike protein has also been predicted to be the major factor driving cross-species transmission, allowing the emergence of epidemic strains like SARS- and MERS-CoV. In the f…
MARK L DELL'ACQUA · UNIVERSITY OF COLORADO DENVER · 2021 · $595,402 — Plasticity in the hippocampus leads to persistent changes in synaptic structure and function that underlie learning and memory. Intracellular Ca2+ signaling pathways activated downstream of NMDA receptors (NMDAR) and L-type voltage-gated Ca2+ channels (LTCC) contribute to changes synaptic function t…
Mikhail G Kolonin · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2021 · $368,900 — White adipose tissue (WAT) is the main lipid reservoir that becomes dysfunctional in obesity. It is important to understand how breached lipid homeostasis leads to metabolic disease. Efficient long chain fatty acid (FA) and cholesterol trafficking depends on a transmembrane transporter protein CD36.…
MARK J SCHNITZER · STANFORD UNIVERSITY · 2021 · $875,437 — Abstract Groundbreaking work within the NIH BRAIN Initiative has revealed many new types of neurons and their genetic signatures. The dividends from this research will include sophisticated tools allowing selective genetic access to these cell-types, such as for imaging, optogenetic or tracing studi…
Robert G Lowery · BELLBROOK LABS, LLC · 2021 · $390,500 — Abstract SARS CoV-2 and related coronaviruses hijack host proteins to facilitate cell entry, replication and immune suppression. Targeting hijacked host proteins is an attractive strategy for development of broad-spectrum antiviral drugs because the same proteins are often targeted by multiple virus…
Lanying Du · GEORGIA STATE UNIVERSITY · 2021 · $766,055 — Summary A novel coronavirus (CoV), SARS-CoV-2, is causing global pandemics with growing numbers of daily cases and deaths. SARS-CoV-2 is closely related to SARS-CoV, which caused the 2002-2003 SARS epidemic, and less closely related to MERS-CoV, which causes a high mortality rate in infected patient…
URSZULA T IWANIEC · OREGON STATE UNIVERSITY · 2021 · $72,235 — PROJECT SUMMARY SARS-CoV-2, the viral cause of Coronavirus Disease 2019 (COVID-19), is a highly contagious coronavirus, which upon infection results in a non-uniform distribution of clinical response. SARS-CoV-2 infects the lung and other organs, including liver and immune system, with non-lung infe…
Suiqiong Li · DL ADV-TECH, LLC · 2021 · $242,132 — Summary/Abstract: The availability of COVID-19 vaccines is a significant step in ending this pandemic and returning life to normal. Successfully vaccination should induce sufficient titers of specific neutralizing antibodies (nAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…
THOMAS T PERLS · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $337,810 — Assessing accuracy of protein measurements across multiple analytical platforms. Our NIA funded project, UH2AG064704 “Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies”, is a phased UH2/UH3 project. We are currently in the UH2 phas…
Julie Champion · GEORGIA INSTITUTE OF TECHNOLOGY · 2021 · $397,382 — Abstract SARS-CoV-2 has spread rapidly across the globe. While vaccines are in development and existing drugs have shown some efficacy in reducing disease severity, there is an urgent need for molecules that can serve in both a prophylactic and therapeutic function. Proteins are well suited for this…
Melodie Lynn Weller · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $228,750 — Project Summary | Role of Salivary Gland Localized SARS-CoV-2 Infection in Oral Tolerance & Immunization Efficacy Over 5 million individuals in the United States have been diagnosed with systemic acute respiratory syndrome coronavirus-2, SARS-CoV-2, infections 1. One of the primary unanswered quest…
John R Cirrito · WASHINGTON UNIVERSITY · 2021 · $433,266 — ABSTRACT/PROJECT SUMMARY Coronavirus 2019 (COVID-19) has afflicted 6.2 million Americans and killed 190,000 as of early September 2020 (WHO website); a roughly 3% mortality. Between a shortage in testing and unidentified asymptomatic individuals, the actual number of those infected could be 6 to 24…
Wonpil Im · LEHIGH UNIVERSITY · 2021 · $199,748 — PROJECT SUMMARY/ABSTRACT The current pandemic of Coronavirus Disease-2019 (COVID-19) has had devastating impacts across the world. In order to enter human host cells, SARS-CoV-2, the virus causing COVID-19, uses its surface spike (S) protein to attach to host cell surface receptors. Besides the best…