NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Irina Leonidovna Grigorova · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $513,210 — Various nanoparticles (NPs) have been used for delivery of small antigens, which have limited viral mimic features and are more efficacious than soluble antigens in stimulating B-cell immunity. However, these traditional NPs lack characteristics of virus “spiky capsid protein peplomer”, e.g. spiky a…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
JEAN S BAUM · RUTGERS, THE STATE UNIV OF N.J. · 2021 · $221,154 — Abstract The overarching goal in this proposal is to understand how molecular motions and biophysical properties modulate protein interactions to promote normal homeostasis or pathological disease states. We investigate the relationship between protein dynamics and interactions in three contexts: 1)…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Barton F. Haynes · DUKE UNIVERSITY · 2021 · $17,521,953 — Abstract - Overall Compared to SARS-CoV-1 and MERS, the current SARS-CoV-2 virus is highly transmissible and to date has caused over 85,000,000cases worldwidewith over 1,800,000 deaths. With an endemic population of multipleother strains of CoVs in bats, rodents with intermediate hosts, civets and p…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Samuel Matthew Young · UNIVERSITY OF IOWA · 2021 · $385,434 — The diversity of information encoding by neuronal circuits is regulated by the magnitude and location of Ca2+ entry though voltage-gated Ca2+ channels (CaV). In the mammalian central nervous system, the CaV2.1 channel is the critical subtype for CNS function since it is the most efficient CaV2 subty…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Michael A Portman · SEATTLE CHILDREN'S HOSPITAL · 2021 · $56,324 — PROJECT SUMMARY Kawasaki Disease (KD) is systemic autoinflammatory vasculitis occurring in children and showing predilection for attacking the coronary arteries. Despite 60 years of research, the etiology and pathogenesis for KD still require elucidation. The predominant hypothesis regarding pathoge…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Darrell J Irvine · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $752,435 — SpongeBot represents a new class of genetically modified cells to address the COVID-19 pandemic, leveraging a novel antiviral platform developed under the proposer team’s existing NIH NIBIB R01 project. This antiviral platform facilitates rapid, targeted SpongeBot development and deployment against …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Karen L. Kotloff · UNIVERSITY OF MARYLAND BALTIMORE · 2021 · $509,201 — Project Summary/Abstract The University of Maryland School of Medicine (UMSOM) Center for Vaccine Development and Global Health (CVD) has been an established VTEU site since 1974. The goal of the VTEUs is to initiate innovative concepts for clinical research and implement clinical site protocols for…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Francesca-Fang Liao · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2021 · $1,967,005 — Abstract White matter (WM) damage has increasingly been recognized as an important contributing factor to neurodegeneration and dementia, however, little is known of the specific molecular and cellular events underlying the pathogenesis. Clinically, chronic hypoperfusion is often associated with WM …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
John D Mountz · BIRMINGHAM VA MEDICAL CENTER · 2021 — The COVID-19 caused by the SARS-CoV-2 coronavirus infection is currently a global pandemic. The most important question is why some individuals produce rapid protective antibodies (Abs) and exhibit null or only mild symptoms, whereas others do not? A second urgent question is if a standard laborator…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Kerry L Burnstein · MIAMI VA HEALTH CARE SYSTEM · 2021 — COVID-19 poses a tremendous health threat, particularly to individuals overrepresented in the US Veteran community. COVID-19 mortality is greater in men than in women; while this disparity is at least partially due to factors such as higher rates of smoking, a hormonal link is likely and can be rapi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Yingjie Chen · PURDUE UNIVERSITY · 2021 · $122,453 — Project Summary Cryo-electron microscopy (cryoEM) revolutionized structural biology, providing a powerful method to study biological specimens in their native environment. However, a major bottleneck hindering the wider use of cryoEM is the lack of trained professionals capable of proficiently opera…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Ralph S Baric · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $748,081 — The 21st century has recorded the emergence of three highly pathogenic respiratory coronaviruses, including Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003, the ongoing Middle East Respiratory Coronavirus (MERS-CoV) in 2013 and a novel SARS-like coronaviruses SARS-CoV2 (SARS2) in Wuhan, Chin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Masashi Tabuchi · CASE WESTERN RESERVE UNIVERSITY · 2021 · $386,030 — Project Summary/Abstract The idea that information processing depends on neuronal firing rate (rate coding) has long been a central dogma in neurobiology. However, other non-canonical coding schemes (temporal and “analog” codes) have been proposed to carry meaningful information and be more computat…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Luis J Montaner · WISTAR INSTITUTE · 2021 · $1,571,599 — Project Summary The Coronavirus Disease 2019 (COVID-19) pandemic is currently gripping the world without a known cure or prevention. Aside from the health consequences, the necessary decrease in human activity has resulted in economic losses without modern precedent, especially in the developing wor…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Richard Dean Braatz · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $500,000 — Project Summary: A modular platform for rapid VLP vaccine development and manufacturing for SARS-CoV-2 pandemic response This proposal aims to design, develop, and manufacture a virus-like particle (VLP) vaccine for SARS-CoV-2, and the techniques developed throughout the work can be applied to accel…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Zhenyu Zhong · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $410,000 — Project Summary A balanced supply of deoxynucleoside triphosphates (dNTPs), the building blocks for DNA, is vital for the synthesis or repair of both nuclear and mitochondrial genomes, whereas its imbalance results in genome instability that precipitates cellular damage and breach of homeostasis. Re…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Jonathan Kyle Pokorski · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $237,000 — Summary The rapid development, distribution and administration of a COVID-19 vaccine to the global population is the most effective approach to quell this pandemic and future reoccurrence. Vaccination must occur broadly both in well-resourced and resource-poor areas of the world to be most effective…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
David R Tabatadze · ZATA PHARMACEUTICALS, INC. · 2021 · $717,598 — ABSTRACT Presently, convalescent plasma (CP) transfusion is being developed as a therapy for COVID-19 patients and as a prophylactic for high risk individuals. In addition, treatment with plasma or neutralizing antibody preparations from convalescent patients could be the only treatment for emergin…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
JEFFREY K ACTOR · 7 HILLS PHARMA, LLC · 2021 · $297,724 — Abstract On March 11, 2020 the World Health Organization (WHO) announced a global Coronavirus Disease 2019 (COVID-19) pandemic. The disease is characterized by severe flu-like symptoms, with advanced age (>65 years) an important risk factor for SARS-CoV-2-induced death. Current clinical stage CoV-2 …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2021
Rama Rao Amara · EMORY UNIVERSITY · 2021 · $187,664 — The overall goal of this proposal is to develop effective prophylactic vaccines against the novel SARS Coronavirus-2 (SARS-CoV-2) infection that has recently emerged as a pandemic across the world. The SARS-CoV-2 has already infected more than 120,000 people and over 4000 people died due to COVID-19…