Document text
Introduction to the
Lyme Disease Vaccines Work Group
Grace E. Marx, MD, MPH
Lead, Lyme Disease Vaccines Work Group
April 15, 2025
Advisory Committee on Immunization PracticesNational Center for Emerging and Zoonotic Infectious Diseases
•Most common vector -borne disease in the U.S.
•An estimated 476,000 people in the U.S. diagnosed and treated for Lyme
disease each year1
•Estimated to cost $345– 968 million annually in health care costs2Public Health Problem –Lyme disease
1. Kugeler K et al. Emerg Infect Dis 2021: 27(2):616– 619.
2. Hook S. et al. Emerg Infect Dis 2022: 28(6):1170– 1179.
•1990s
-Several vaccines developed, each containing OspA antigens from Borrelia burgdorferi
-OspA antibodies neutralize spirochete in the tick midgut, thus preventing
transmission
-LYMErix ® licensed 1998; available 1998 – 2002 until discontinued by manufacturer
due to low demand
•2010s – 2020’s
-Steady increase in Lyme disease incidence, with expansion outward from high -
incidence areas in the Northeast, mid -Atlantic, and Midwest
-VLA15, a multivalent recombinant protein vaccine , currently in phase 3 clinical trials
-mRNA vaccine candidates in early clinical trialsLyme Disease Vaccines Development
•Review epidemiology and burden of Lyme disease
•Review data about risk for Lyme disease
•Review safety, immunogenicity, and efficacy data for Lyme disease vaccine
candidates
•Review economic analyses related to Lyme disease vaccination
•Develop Lyme disease vaccination policy options
•Identify areas where additional data are neededACIP Lyme Disease Vaccines Work Group Objectives
•Chair and work group members
-TBD
•Lead
-Grace MarxACIP Lyme Disease Vaccines Work Group
•May 2025 – first work group meeting
•June 2025 – ACIP presentation
-Epidemiology, burden, and clinical manifestations of Lyme diseaseACIP Lyme Disease Vaccines Work Group Initial Timeline
For more information, contact CDC
1-800- CDC- INFO (232 -4636)
TTY: 1 -888- 232- 6348 www.cdc.gov
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Thank you.