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Principal Investigator: Leonardo Trasande
Organization: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Fiscal Year: 2020
Award: $339,000
Funding agency: NIH Office of the Director
PROJECT SUMMARY
The novel coronavirus pandemic (COVID-19) has largely spared children, with relatively few requiring medical
care. A small case series failed to reveal effects on birth outcomes in mothers with COVID-19 pneumonia, yet
the absence of effects may in part relate to these mothers having been infected in third trimester, as the timing
of infection is well known to influence adverse effects in pregnancy. A major barrier to population-based
studies of SARS-CoV-2 infection has been the lack of a noninvasive method to detect viral RNA.
Nasopharyngeal swabs are invasive, require personal protective equipment and swabs which have been in
limited supply, and may be less sensitive than salivary samples for SARS-CoV-2 detection. Studies of
adaptive immunity following infection in children have also been limited by the need for venipuncture to collect
sufficient serum for validated testing of antibody. Our research team has developed novel methods for
measuring SARS-CoV-2 infection in saliva, as well as IgG and IgM antibody responses to the spike protein and
the receptor binding domain of SARS-CoV-2 in dried blood spots (DBS). Substantial psychosocial stress is
likely to have occurred in pregnant women during the pandemic, whether due to fear of infection, job loss,
economic stress, psychological or physical trauma, or other factors. Psychological stress during pregnancy is
known to increase prematurity, yet stress and viral effects have not been examined together as yet. We had
previously received PO permission to reallocate Year 4 funds in the NYU Children’s Health and Environment
Study (CHES, UH3OD23305) and the Columbia Center for Children’s Environmental Health (CCCEH,
UH3OD023290) to add remote and repeated saliva, dried blood spot, and hair collection in cohorts
prospectively enrolling mothers into ECHO, using kits assembled by Fisher BioSciences for the ECHO
program. We propose to expand this effort over the next year to newly enrolled mothers in NYU CHES (N=200
mothers), CCCEH (N=20 mothers) as well as the Michigan Archive for Research in Children’s Health (MARCH,
UH3OD23285, N=20 mothers). We also wish to continue data collection in already enrolled NYU CHES
(N=340 pregnant women as of March 1, 2020) and CCCEH (N=40 pregnant women as of March 1, 2020)
mothers. The data will be supplemented by chart abstraction for all SARS-CoV-2 testing.
Terms: <0-11 years old><19S Gamma Globulin><2019 novel coronavirus><2019-nCoV><3rd trimester><7S Gamma Globulin><Adverse effects><Aeroseb-HC><Amniotic Fluid><Antibodies><Antibody Response><Aqua Amnii><Archives><Authorization><Authorization documentation><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biologic Sciences><Biological><Biological Sciences><Bioscience><Birth><Birth Weight><Blood><Blood Reticuloendothelial System><Blood Serum><CDC><COVID-19><COVID19><Caring><Case Series><Cells Placenta-Tissue><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Cetacort><Child><Child Health><Child Youth><Children (0-21)><China><Chronic><Clinical><CoV emergence><Collection><Conditioning Therapy><Cord Blood><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Data Collection><Dermacort><Detection><Economics><Eldecort><Enrollment><Environment><Environmental Exposure><Environmental Health><Environmental Health Science><Equipment><Failure><Fear><Fright><Funding><Gestation><Hair><History><Hydrocortisone><Hydrocortone><Hypercoagulability><Hytone><IgG><IgM><Immunoglobulin G><Immunoglobulin M><Infection><Inflammatory><Intermediary Metabolism><Italy><Jobs><Kidney><Kidney Urinary System><Last Trimester><Length><Life Sciences><Liquor Amnii><Literature><Mainland China><Measurement><Measures><Mediating><Medical><Metabolic Processes><Metabolism><Methods><Michigan><Mothers><NIH><National Institutes of Health><Neonatal><New York><Non-Polyadenylated RNA><Normal Placentoma><Nutracort><Occupations><Outcome><Parturition><Patients><Perinatal Exposure><Permission><Pharyngeal structure><Pharynx><Placenta><Placenta Embryonic Tissue><Placentome><Pneumonia><Population><Population Study><Pregnancy><Pregnant Women><Proctocort><Professional Positions><Prospective cohort><Proteins><Psychologic Stress><Psychological Stress><Psychosocial Stress><Questionnaires><RNA><RNA Gene Products><Recording of previous events><Reporting><Research><Ribonucleic Acid><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Saliva><Salivary><Sampling><Serum><Severe acute respiratory syndrome coronavirus 2><Shelter facility><Spottings><Stress><Swab><Symptoms><Syndrome><Testing><Third Pregnancy Trimester><Third Trimester><Throat><Thrombophilia><Trauma><Umbilical Cord Blood><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Urine><Urine Urinary System><Venipunctures><Viral><Virus><Wuhan coronavirus><acute stress><adaptive immunity><behavior intervention><behavioral intervention><child adiposity><child obesity><childhood adiposity><childhood obesity><children><childrens'><cohort><corona virus disease 2019><coronavirus disease 2019><coronavirus emergence><emergent CoV><emergent coronavirus><emerging CoV><emerging coronavirus><enroll><expectant mother><expecting mother><fetal cord blood><meetings><nCoV><new CoV><new coronavirus><novel><novel CoV><novel coronavirus><obese children><obesity during childhood><obesity in children><pandemic><pandemic disease><pediatric obesity><perinatal outcomes><population-based study><population-level study><pregnant mothers><premature><prematurity><programs><psychologic><psychological><receptor binding><receptor bound><renal><response><sample collection><seropositive><shelter><shelter-housing><specimen collection><studies of populations><study of the population><symptomatology><viral RNA><virus RNA><youngster>