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Principal Investigator: Connor J McCabe
Organization: UNIVERSITY OF WASHINGTON
Fiscal Year: 2024
Award: $249,000
Funding agency: National Institute on Alcohol Abuse and Alcoholism
The long-term objective of this Pathway to Independence Award is to support candidate Dr. McCabe
in building an independent research program and to facilitate his transition into an independent faculty
research position. To date, Dr. McCabe’s research has focused on 1.) refining quantitative methods applied in
addictions research, and 2.) understanding individual differences in stress, developing self-regulation, and their
associations with alcohol use (AU) among sexual minority and non-minority communities. Dr. McCabe seeks to
expand his training in AU development, minority stress theory, and applied quantitative methods to a new
emphasis on intersectionality and sexual and gender minority (SGM) AU risk, machine learning and multilevel
methodologies, and ecological factors influencing AU disparities. This long-term objective will be achieved
through a five-year training plan involving a carefully selected mentorship team as well as targeted coursework
and hands-on training experiences. The goals of the proposed research are to 1) distinguish SGM subgroups
and intersections at heightened risk for AU (e.g., bisexuals and trans persons, SGM young women of color), 2)
assess the role of state policies in moderating AU risk, and 3) delineate moderators and mechanisms of
heightened AU across SGM populations within and beyond the coronavirus pandemic. The mentored phase
(K99) will involve cross-sectional analysis of the All of Us Research Program (AURP), a large (N=331,360) and
diverse national dataset. Aim 1 will identify heterogeneity in alcohol and other substance use behaviors among
sexual (1a; n=38,820 non-heterosexual) and gender minority (1b; n=2,660 transgender or nonbinary)
communities. It will then test race/ethnicity and age as intersectional moderators of SGM inequities (1c) and
state-level policies impacting SGM communities (1d; e.g., hate crime laws enumerating SGM identity) that
further differentiate AU risk among SGM groups. During the independent phase, findings will be extended to
address mediators and moderators of AU in the monthly AURP COVID-19 Participant Experience Survey (Aim
2; n=100,340) as well as the longitudinal, biennial AURP data that extends beyond the pandemic into 2027
(Aim 3). Aim 2 will test pandemic stressors as mediators of between-person AU among SGM intersections
(2a) and examine intersectional (2b) and multilevel moderators (2c) of within-person AU. Aim 3 will test
differences in post-pandemic recovery in AU among SGM intersections (3a) and determine pandemic
mediators (3b) and moderators (3c) of this change. Findings will serve as the foundation for an NIAAA R01
submission during the R00 phase focused on geocoded neighborhood-level factors influencing developing
alcohol risk across adolescence and young adulthood across SGM intersections. Mentors (Drs. Rhew, Lee,
Helm) and consultants (Drs. Grimm, Bauer, Raifman) are committed to the candidate’s training, each providing
unique expertise to the research and training plan. This award will support the candidate’s development as an
independent cross-disciplinary prevention scientist in AU disparities and quantitative methods.
Terms: <12-20 years old><21+ years old><Address><Adolescence><Adult><Adult Human><Adult females><Adult women><Advocacy><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><All of Us Program><All of Us Research Program><All of Us Research Project><AoURP><Automobile Driving><Award><BIPOC><Behavior><Bi-sexual><Bisexual><Black, Indigenous, People of Color><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caucasian Females><Caucasian Women><CoV pandemic><Cognitive Discrimination><Communities><Complex><Consensus><Coronavirus Infectious Disease 2019><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Set><Development><Discrimination><Disease><Disease Frequency Surveys><Disorder><Disparities><Disparity><Employment><Equation><EtOH drinking><EtOH use><Ethnic Origin><Ethnicity><Female><Females in adulthood><Financial Hardship><Foundations><Future><Gender><Gender and Sexual Minorities><Generalized Growth><Goals><Growth><Health><Heterogeneity><Heterosexuals><Housing><Individual><Individual Differences><Inequity><Informal Social Control><K-Awards><K-Series Research Career Programs><LGB><Laws><Lesbian Gay Bi-Sexual><Lesbian Gay Bisexual><Link><Machine Learning><Mediating><Mediator><Mentors><Mentorship><Methodology><Methods><Modeling><NIAAA><NIH><National Institute on Alcohol Abuse and Alcoholism><National Institutes of Health><Neighborhoods><Participant><Pathway interactions><Persons><Phase><Policies><Population><Position><Positioning Attribute><Prevention><Process><Public Health><Race><Races><Recovery><Reporting><Research><Research Career Program><Research Resources><Resources><Risk><Risk Factors><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Scientist><Self Regulation><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sexism><Sexual and Gender Minorities><Social status><Social support><Stigmatization><Stress><Subgroup><Survey Instrument><Surveys><Symptoms><Testing><Tissue Growth><Training><Underserved Population><United States National Institutes of Health><White Females><White Women><Woman><Women in adulthood><Work><addiction><addictive disorder><adolescence (12-20)><adult youth><adulthood><ages><alcohol ingestion><alcohol intake><alcohol misuse><alcohol prevention><alcohol product use><alcohol risk><alcohol use><alcoholic beverage consumption><alcoholic drink intake><black female><black women><career><cis-gender><cisgender><coping><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><coronavirus pandemic><developmental><discrete data><driving><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol use><experience><faculty research><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><forest><gender minority><gender minority community><gender minority group><gender minority individual><gender minority men><gender minority people><gender minority population><gender minority status><global health><hate crimes><high dimensionality><high risk><intersectionalities><intersectionality><machine based learning><machine learning based method><machine learning method><machine learning methodologies><marginalization><minority stress><minority stresses><minority stressor><non-heterosexual><nonbinary><nonheterosexual><novel><ontogeny><pandemic><pandemic associated stress><pandemic associated stressor><pandemic disease><pandemic effect><pandemic impact><pandemic induced stress><pandemic outcome><pandemic related stress><pandemic related stressor><pandemic repercussions><pandemic stress><pandemic stressor><pathway><post-pandemic><pre-pandemic><prevent alcohol><preventing alcohol><programs><psychologic><psychological><public health intervention><racial><racial background><racial origin><racism><random forest><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex><sexual minority><sexual minority group><sexual minority individual><sexual minority people><sexual minority population><social><social position><social role><social standing><social support network><stress among minorities><stress due to pandemic><stress during the pandemic><stress in minorities><stress to minorities><stressor><substance use><substance using><theories><trans*><trans-women><transgender><transgender women><transwoman><transwomen><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><unhealthy alcohol use><women of color><young adult><young adulthood><young woman>