Document text
Principal Investigator: Dustin T Duncan
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
Fiscal Year: 2024
Award: $715,456
Funding agency: National Institute on Drug Abuse
PROJECT SUMMARY
Black gay, bisexual and other men who have sex with men (MSM) face a disproportionate burden of HIV.
Focused, high-coverage PrEP in populations heavily impacted by HIV, such as Black MSM, could rapidly
reduce new HIV acquisition rates; however, its uptake among at-risk populations, especially Black MSM, has
been limited. Therefore, we propose to conduct urgently needed research on PrEP in a cohort of Black MSM,
including on the impact of relevant behaviors, particularly cannabis use, which is highly prevalent in Black
MSM. Research on the impact of cannabis use on PrEP has achieved conflicting results, and it has not been
rigorously studied in Black MSM. Therefore, the proposed R01 study will assess cross-sectional and
longitudinal associations between cannabis use and PrEP outcomes (e.g., use, adherence) and HIV
transmission risk (e.g. biological inflammation, sexual risk behavior) using event-level and objective biomarker
data among HIV-negative Black SMM. To address these specific aims, we will conduct the Networks and
Neighborhoods (N2) Cannabis PrEP Study in Chicago, IL. We will follow 250 HIV-negative participants from
the original N2 cohort for an additional one-year period with 3 study waves. We will use innovative and rigorous
methods, to collect additional data, such as Ecological Momentary Assessment methods and objective
measures of cannabis use, PrEP use, and immune function over 14-day periods at each wave. Potential
findings can impact intervention development and implementation, as well as inform policy to increase PrEP
uptake and adherence, address substance use, and decrease HIV transmission rates, and disparities.
Terms: <AAMSM><AIDS Virus><AIDS prevention><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><African American MSM><African-American men who have sex with men><Alcohol Chemical Class><Alcohols><Awareness><BMSM><Behavior><Bi-sexual><Biological><Biological Markers><Bisexual><Black><Black race><Blood Plasma><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><Cannabis><Cellular Immune Function><Characteristics><Chicago><Cognitive><Cohort Studies><Concurrent Studies><Coronavirus Infectious Disease 2019><Data><Disparities><Disparity><Drug usage><Drugs><Ecological momentary assessment><Enrollment><Environment><Epidemic><Epidemiology><Equity><Event><Face><Funding><Gays><Groups at risk><HIV><HIV Infections><HIV Prevention><HIV Seronegativities><HIV Seronegativity><HIV negative><HIV/AIDS><HIV/AIDS prevention><HIV/STD><HIV/STI><HTLV-III Infections><HTLV-III Seronegativities><HTLV-III Seronegativity><HTLV-III-LAV Infections><Health Inequity><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Immune><Immunes><Immunology><Incidence><Individual><Inequalities in Health><Inequities in Health><Inflammation><Infrastructure><Intervention><Intervention Strategies><Knowledge><LAV-HTLV-III><Legal><Link><Lymphadenopathy-Associated Virus><MSM><Measures><Mediating><Mediator><Medication><Methods><NIH><National Institutes of Health><Neighborhoods><Outcome><Participant><People at risk><Persons at risk><Pharmaceutical Preparations><Plasma><Plasma Serum><Policies><Population><Populations at Risk><PrEP><Prevention><Prospective, cohort study><Public Health><Rectum><Reporting><Research><Reticuloendothelial System, Serum, Plasma><Risk><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><STD/HIV><STI/HIV><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sex Behavior><Sexual Activity><Sexual Behavior><Shelter facility><Social Network><Stimulant><Survey Instrument><Surveys><THC co-use><THC use><Technology><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Transmission><Typology><United States><United States National Institutes of Health><Virus-HIV><Visit><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biomarker><black MSM><black men who have sex with men><cannabis use><cohort><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus infectious disease-19><cytokine><develop therapy><drug use><drug/agent><enroll><epidemiologic><epidemiological><faces><facial><health inequalities><immune function><innovate><innovation><innovative><intervention development><interventional strategy><marijuana use><men><men having sex with men><men who have sex with men><men who have sex with other men><multiple substance use><multisubstance use><poly substance use><polysubstance use><pre-exposure prophylaxis><racial minority group><racial minority individual><racial minority people><racial minority population><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex activity><sex risk behavior><sexual activities><sexual minority group><sexual minority individual><sexual minority people><sexual minority population><sexual risk behavior><shelter><shelter housing><shelters><social><social role><substance use><substance using><therapy development><transmission process><treatment development><uptake>