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Principal Investigator: Kathryn M. Anastos
Organization: ALBERT EINSTEIN COLLEGE OF MEDICINE
Fiscal Year: 2024
Award: $680,084
Funding agency: National Institute of Allergy and Infectious Diseases
PROJECT SUMMARY
ERC-CFAR: CLINICAL AND TRANSLATIONAL SCIENCE CORE (CTSC)
To help meet the vision of Ending the HIV Epidemic (EHE), the Einstein-Rockefeller-CUNY Center for AIDS
Research (ERC-CFAR) has formed strong collaborations both within and beyond our partner institutions,
including the New York City Department of Health and Mental Hygiene, to catalyze and support research that
best serves the public’s health: to eradicate HIV infection, prevent new HIV infections, and improve the health
of people living with HIV (PWH). The overarching goal of the ERC-CFAR and the Clinical and Translational
Science Core (CTSC) is to support the EHE mission by creating a broad and robust resource available to
researchers within our walls as well as nationally and globally. Our synergistic partnership provides a broad
range of support for clinical, translational, health services, and implementation science investigations. By
leveraging the resources of the Einstein CTSA-funded Institute for Clinical and Translational Research, the
CTSC provides access to a robust clinical database and multiple biorepositories. The Clinical Cohort Database
(CCDB), derived from the Montefiore/Einstein clinical services, has ~20,000 PWH and 475,000 HIV-negative
patients; >6200 PWH are in active care; 43% are women, 48% Hispanic/Latinx and 41% African American. This
comprehensive, longitudinal database accesses Montefiore’s extensive clinical infrastructure and has fostered
an explosion of clinical prevention and treatment, epidemiologic, translational, health services and
implementation science research. We facilitate enrollment of well-characterized patients (including HIV-negative
controls) into new research protocols. Through CTSC resources the clinical population at Montefiore/Einstein
enables research at Rockefeller, which lacks access to defined cohorts of PWH, recruiting new participants for
Rockefeller’s cutting-edge research in HIV eradication. The City University of New York (CUNY) is a leader in
implementation science assessing the factors that influence our ability to impact favorably on the public’s health
with interventions of proven efficacy. The CTSC is integrated into the Scientific Working Group, a driver of the
ERC-CFAR’s scientific direction, to provide optimal support to the emerging research activities, and foster cross-
fertilization among cores and the SWG. We will leverage Einstein’s Center for Health Data Innovations and use
of state-of-the-art informatics methods, including natural language processing and machine learning, to catalyze
and facilitate new research in primary prevention of HIV infection, while maintaining our extensive support of
well-established research areas.
Terms: <AIDS><AIDS Virus><AIDS prevention><Access to Care><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><African American><Afro American><Afroamerican><Application Context><Area><Behavioral><Biometrics><Biometry><Biostatistics><COVID-19><CV-19><Caring><Characteristics><Cities><Clinical><Clinical Research><Clinical Sciences><Clinical Services><Clinical Study><Clinical Trials><Clinical and Translational Science Awards><Clinical effectiveness><Cohort Studies><Collaborations><Color><Community Health><Concurrent Studies><Conduct Clinical Trials><Consent><Consultations><Coronavirus Infectious Disease 2019><Creativeness><Data><Data Analyses><Data Analysis><Data Bases><Data Systems><Databases><Development><Discipline><Electronic Health Record><Enrollment><Epidemic><Epidemiology><Explosion><Fertilization><Fostering><Funding><Genetic><Gestation><Goals><HIV><HIV Infections><HIV Prevention><HIV Seronegativities><HIV Seronegativity><HIV negative><HIV/AIDS prevention><HTLV-III Infections><HTLV-III Seronegativities><HTLV-III Seronegativity><HTLV-III-LAV Infections><Health><Health Care Utilization><Health Services><Health Services Accessibility><Health system><Heterosexuals><Hispanic><Human><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><IRB><IRBs><IT Systems><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Individual><Informatics><Information Systems><Information Technology Systems><Infrastructure><Institution><Institutional Review Boards><International><Intervention><Intervention Strategies><Investigation><Investigators><LAV-HTLV-III><Latine><Latinx><Leukapheresis><Leukocytapheresis><Link><Logistics><Lymphadenopathy-Associated Virus><MSM><Machine Learning><Mental Health><Mental Hygiene><Methods><Migrant><Mission><Modern Man><NIH><National Institutes of Health><Natural Language Processing><New York><New York City><Outcome><Participant><Patient Recruitments><Patients><Persons><Phenotype><Policies><Population><Population Heterogeneity><PrEP><Pregnancy><Pregnant Women><Prevention><Primary Prevention><Procedures><Prospective Studies><Protocol><Protocols documentation><Provider><Psychological Health><Public Health><Research><Research Activity><Research Design><Research Personnel><Research Resources><Research Specimen><Research Support><Researchers><Resources><Retrospective Studies><Science><Scientist><Services><Shipping><Sight><Social Support System><Source><Specific qualifier value><Specified><Specimen><Study Type><Support System><System><Therapeutic Leukopheresis><Translational Research><Translational Science><Underrepresented Groups><Underrepresented Populations><United States National Institutes of Health><Universities><Update><Virus-HIV><Vision><Woman><Work><access to health services><access to services><access to treatment><accessibility to health services><availability of services><biobank><biorepository><brain MR imaging><brain MRI><brain magnetic resonance imaging><cardiac MRI><cardiac magnetic resonance imaging><care access><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><clinical database><clinical infrastructure><cohort><community-based health><consultation><contextual factors><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><creativity><data base><data infrastructure><data interpretation><depository><developmental><diverse populations><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><enroll><epidemiologic><epidemiological><expectant mother><expecting mother><experience><fertilizations><health care service use><health care service utilization><health data><health service access><health services availability><healthcare service use><healthcare service utilization><healthcare utilization><heterogeneous population><high risk><implementation science><improved><innovate><innovation><innovative><interventional strategy><longitudinal database><machine based learning><men having sex with men><men who have sex with men><men who have sex with other men><natural language understanding><novel><operation><operations><participant enrollment><participant recruitment><patient enrollment><patient population><population diversity><pre-exposure prophylaxis><pregnant mothers><prevent><preventing><prevention service><programs><prospective><recruit><repository><research study><sample collection><service availability><specimen collection><study design><substance user><trans*><transgender><translation research><translational investigation><translational investigator><translational researcher><translational scientist><treatment access><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><visual function><work group><working group>