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Principal Investigator: Todd C. Skaar
Organization: INDIANA UNIVERSITY INDIANAPOLIS
Fiscal Year: 2024
Award: $68,494
Funding agency: National Cancer Institute
ABSTRACT, Cancer Prevention and Control (CPC) Research Program
The overall goals of the CPC Program, which are aligned with the Indiana University Simon Comprehensive
Cancer Center (IUSCCC) Strategic Plan and guided by the unique needs and priorities of our catchment area,
are to 1) decrease the incidence of cancer and 2) decrease the impact of cancer diagnoses and treatments on
the lives of survivors and their families. Serving these goals, the CPC Program focuses its work on two themes,
each with two aims: Theme 1) Risk Reduction and Early Detection (includes Aims 1 and 2), and Theme 2)
Survivorship and Symptom Science (includes Aims 3 and 4). Within each theme, CPC members address two
aims related to the identification of risk factors and the development and testing of interventions. Theme 1 is
focused on risk reduction and early detection, discovering genetic, biological, social, and behavioral risk factors
that contribute to the development of major cancers affecting the people of Indiana (Aim 1) and developing and
evaluating innovative models and interventions that reduce cancer risk, improve screening, and increase early
detection of cancers (Aim 2). Theme 2 is focused on survivorship and symptom science, identifying genetic,
biological, social, and pharmacogenomic risk factors associated with cancer symptoms and treatment-related
toxicities (Aim 3) and developing and testing interventions to reduce treatment-related symptoms and enhance
survivorship for cancer patients and their families (Aim 4). Efforts to include underrepresented populations in
research, to reduce disparities in cancer care delivery, and to improve health equity are integrated across all four
aims. In 2018, the Program was evaluated as “Outstanding.” Since the prior review, CPC membership has nearly
doubled from 37 (in 2018) to 63 members: 34 Full and 29 Associate Members, representing 24 Departments
and seven Schools on the campuses of Indiana University at Indianapolis, Indiana University at Bloomington,
and Purdue University. Since the last review, CPC funding has grown from $6.3M to $10.8M in peer-reviewed
direct cost funding, representing a 71% increase. Current NCI direct cost funding is $5.1M compared to $2.8M
reported in 2018, representing an 85% increase. Over the past funding period, CPC members authored 821
publications, up from 409 in 2018, representing a 100% increase. Of these, 25% are from intra-programmatic
collaborations, 34% inter-programmatic collaborations, and 55% inter-institutional collaboration, with 16% in
high-impact journals. The CPC Program has 27 multi-PI grants, including 6 inter-institutional, 5 intra-
programmatic, 4 inter-programmatic, and 12 with other IU faculty, reflecting strong collaborations through local,
national, and international networking. Leveraging our momentum, the Program will advance the IUSCCC
Strategic Plan through scientific research focused on population health, health risk reduction, predictive
molecular epidemiology, host toxicity, and social responsibility.
Terms: <Address><Adherence><Affect><Attention><Automobile Driving><Basic Research><Basic Science><Behavioral><Biological><Breast Cancer><CCSG><Cancer Burden><Cancer Center Support Grant><Cancer Control><Cancer Control Research Program><Cancer Control Science><Cancer Patient><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Catchment Area><Center for Cancer Research><Collaborations><Colorectal Cancer><Community Outreach><Comprehensive Cancer Center><Data><Death Rate><Decrease disparity><Development><Diagnosis><Direct Costs><Disparities><Disparity><Early Diagnosis><Education and Training><Environment><Faculty><Family><Fostering><Funding><Future><Generalized Growth><Genetic><Genetic predisposing factor><Goals><Grant><Growth><Health><Incidence><Indiana><Inequity><Institution><International><Intervention><Intervention Strategies><Investigators><Journals><Life><Lower disparity><Magazine><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Malignant neoplasm of pancreas><Medicine><Mentors><Modeling><Molecular Epidemiology><Morbidity><Morbidity - disease rate><NCI Center for Cancer Research><NIH><National Cancer Burden><National Institutes of Health><Pancreas Cancer><Pancreatic Cancer><Patient-Centered Care><Patients><Peer Review><Persons><Pharmacogenomics><Policies><Population><Prevention><Publications><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><Regimen><Reporting><Research><Research Personnel><Researchers><Resource Sharing><Risk><Risk Factors><Risk Reduction><Rural Population><Rural group><Rural people><Schools><Science><Scientific Publication><Screening for cancer><Social Responsibility><Strategic Planning><Supportive Therapy><Supportive care><Survivors><Symptoms><Testing><Tissue Growth><Toxic effect><Toxicities><Training><Training Programs><Training and Education><Translating><Translational Research Enterprise><Treatment-related toxicity><Underrepresented Groups><Underrepresented Populations><United States National Institutes of Health><Universities><Vaccination><Work><advanced disease><advanced illness><anti-cancer research><anti-cancer therapy><biologic><cancer diagnosis><cancer disparity><cancer health disparity><cancer prevention><cancer research><cancer risk><cancer therapy><cancer-directed therapy><cancer-related health disparity><care delivery><community engagement><developmental><disparity in cancer><disparity reduction><diversity, equity, and inclusiveness><driving><early cancer detection><early detection><engagement with communities><equity, diversity, and inclusion><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><genetic risk factor><health equity><improved><improved outcome><inherited factor><innovate><innovation><innovative><inter-institutional><international partnership><international research partnership><interventional strategy><life-long learning><lifelong learning><lung cancer><malignancy><malignant breast tumor><manage symptom><member><mitigate disparity><mortality rate><mortality ratio><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><ontogeny><pancreatic malignancy><personalized drugs><population health><precision drugs><prevent><preventing><programs><psychosocial><racial minority><reduce disparity><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><reduction in disparity><risk-reducing><rural individual><screening><screening cancer patients><screenings><side effect><social><social health determinants><survivorship><symptom management><symptom science><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy toxicity><translation research enterprise><translational research program><treatment toxicity><treatment-associated toxicity><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people>