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Principal Investigator: Marie Krousel-Wood
Organization: TULANE UNIVERSITY OF LOUISIANA
Fiscal Year: 2024
Award: $2,256,760
Funding agency: National Institute of General Medical Sciences
Critical to the success of clinical care and translational science is an awareness by clinicians and researchers
that diseases are characterized by sex and gender differences in epidemiology, pathophysiology, manifestations,
progression, and response to treatment. Harnessing the biological forces that define disease manifestation and
severity in one sex compared to the other may help transform its diagnosis and treatment. Therefore, sex-based
precision medicine (SPM) is fundamental to precision medicine that will benefit women and men. A
transdisciplinary approach is necessary to understand the complex interactions between genes, hormones,
environment, social factors, and disease. The proposed Tulane Center of Biomedical Research Excellence in
Sex-Based Precision Medicine (COBRE in SPM) will address this critical barrier in the field. The overarching
goal of the COBRE in SPM is to 1) create a transdisciplinary center that will investigate sex and gender factors
that interact with other determinants of health to affect biology and disease, 2) prepare early-stage and new
investigators (ESI/NI) for independent federal funding, and 3) achieve national prominence. The Specific Aims
of the COBRE are to 1) create a university-wide center that fosters transdisciplinary collaborations between
basic, clinical, epidemiological, and social sciences to stimulate innovative research and discoveries on the role
of sex and gender in biology, disease, and medicine, 2) develop a critical mass of highly trained investigators
studying SPM and enhance their ability to compete for external funding through a strong mentoring program, 3)
recruit new investigators to the field of SPM research by engaging them in the use of COBRE resources, and 4)
establish an infrastructure to advance the science of SPM and improve health through an innovative Enrichment
Program that will train the next generation of highly qualified SPM investigators. To accomplish these aims, the
COBRE in SPM will rely on the following specific strategies: An Administrative Core to coordinate and supervise
research and pilot projects, scientific mentoring and career development activities, and all components of the
COBRE. Protected time and research support for three Research Project Leaders (RPLs) to allow them to
establish independent, federally funded research programs on SPM. A Structured Career & Mentoring Plan to
assist ESI/NI in advancing their independent research and becoming NIH-funded investigators. A Pilot Project
Program to provide seed support to ESI/NI to catalyze groundbreaking research that will lead to the submission
of successful NIH R01s or to COBRE Research Projects. An SPM Enrichment Program to support 1) a
Curriculum highlighting the importance of SPM; 2) a Bootcamp that provides skill-based training to investigate
SPM for ESI/NI and established scientists; 3) an SPM Seminar Series; and 4) a Workshop and annual
Symposium that showcases advances in SPM research, builds collaborative networks, and promotes SPM
research broadly. An SPM Research Core to serve RPLs and Pilot Project Leaders and provide statistical and
bioinformatics support to investigators studying sex and gender factors.
Terms: <Acceleration><Address><Affect><Age><Applications Grants><Area><Awareness><Behavior><Bio-Informatics><Bioinformatics><Biological><Biology><Biomedical Engineering><Biomedical Research><COBRE><COVID-19><CV-19><Center of Biomedical Research Excellence><Centers of Research Excellence><Clinical><Collaborations><Complex><Coronavirus Infectious Disease 2019><Curriculum><Diagnosis><Differences between sexes><Differs between sexes><Disease><Disorder><Dysfunction><Educational Curriculum><Educational workshop><Endocrine Gland Secretion><Environment><Epidemiology><Equity><Exhibits><Fostering><Functional disorder><Funding><Gender><Generations><Genes><Goals><Grant Proposals><Health><Hormones><Infrastructure><Interdisciplinary Research><Interdisciplinary Study><Investigators><Leadership><Medicine><Mentors><Methods><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Physiopathology><Pilot Projects><Population Sciences><Public Health Schools><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Proposals><Research Resources><Research Support><Researchers><Resources><Role><Schools><Science><Science Enrichment><Scientist><Series><Severities><Sex Differences><Sexual differences><Social Medicine><Social Sciences><Structure><Students><Therapeutic Hormone><Time><Training><Translational Research><Translational Science><Translations><Tropical Medicine><United States National Institutes of Health><Universities><Woman><Work><Workshop><ages><bio-engineered><bio-engineers><bioengineering><biologic><biological engineering><career><career development><clinical care><clinical translation><clinically translatable><conference><convention><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><education research><epidemiologic><epidemiological><gender difference><gender-associated difference><health determinants><improved><innovate><innovation><innovative><interdisciplinary collaboration><interest><investigator training><lesson plans><male><medical college><medical schools><men><mortality><next generation><novel><pathophysiology><pilot study><precision medicine><precision-based medicine><programs><racial><racial background><racial origin><recruit><response to therapy><response to treatment><school of medicine><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><skills><social><social factors><social health determinants><social role><success><summit><symposia><symposium><therapeutic response><therapy response><transdisciplinary collaboration><translation><translation research><translational investigation><treatment response><treatment responsiveness>