Document text
Principal Investigator: Uma Reddy
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
Fiscal Year: 2024
Award: $359,801
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Abstract/Project Summary
The Columbia Center has a 20-year track record of excellence within the Maternal Fetal Medicine Units
(MFMU) Network and collaborating in large multi-site clinical trials and longitudinal studies in pregnant and
lactating people. During the last current cycle of the MFMU, the Columbia Center ranked near the top in
recruitment for every study. The Columbia Center will be composed of Columbia University and 3 satellite
sites including: Christiana Care Health System, Saint Peter's University Hospital, and Yale New Haven
Hospital which operate under a common administrative and oversight structure. Together, these 4 large-
volume delivery centers provide access to 23,500 patients annually with diversity in race and ethnicity (24%
Black, 24% Hispanic, 9% Asian), socioeconomic status, and access to underserved communities. As a result
of our strong presence of MFM, Neonatology and subspecialty care and facilities at each site, 40% of our
overall delivery population is high-risk. Network protocols will be conducted in a coordinated, rigorous and safe
manner by our Center's highly qualified investigators, staff, dedicated MFMU facilities and culture of clinical
research being part of clinical care. The Columbia Center has the experience and expertise to collaboratively
conduct multi-site randomized trials and large observational studies with timely recruitment, community-
engaged enrollment of eligible participants from diverse patient populations with excellent retention and
rigorous data collection to contribute to results which will promote advances in obstetric practice. The
Columbia Center has numerous strengths and will provide multidisciplinary expertise on obstetrics,
neonatology, obstetric pharmacology, infant neurodevelopment and lactation clinical practice to address
maternal death and complications related to pregnancy, labor, and post-partum recovery; to reduce
prematurity, low-birth weight, infant death, and infant complications and expand the evidence base about the
safety and efficacy of medications used during pregnancy and lactation. Our Center has state-of-the-art
scientific capabilities for Network research including imaging, genomics, proteomics, placental function
assessment, innovative trial design and analyses, and specialized support of clinical trials. Lastly, our goal is
to provide rigorous data and biospecimen collection to share as a resource for other investigators to advance
evidence-based obstetric practice.
Terms: <Address><Asian><Awareness><Basic Research><Basic Science><Black><Black race><Bylaw><Caring><Cells Placenta-Tissue><Clinical><Clinical Protocols><Clinical Research><Clinical Study><Clinical Trials><Collaborations><Collection><Communities><Complex><Country><Data><Data Collection><Dedications><Delaware><Discipline><Discipline of obstetrics><Drugs><Enrollment><Equipment><Ethnic Origin><Ethnicity><Genomics><Gestation><Goals><Health><Health Care Systems><Healthcare Systems><Hispanic><Hospitals><Human Resources><Image><Infant><Infant Mortality><Infant Mortality Total><Information Dissemination><Investigators><Lactation><Long-term Follow-up><Longitudinal Studies><Longterm Follow-up><Low Birth Weight Infant><MFMU network><Manpower><Maternal Mortality><Maternal complication><Maternal-Fetal Medicine Units><Maternal-Fetal Medicine Units (MFMU) Network><Maternal-Fetal Medicine Units Network><Maternity Hospitals><Medication><Mentors><Morbidity><Morbidity - disease rate><Multi-Institutional Clinical Trial><Multi-center Neonatal Research Network><Multi-center clinical trial><Multi-site clinical trial><Multicenter Neonatal Research Network><Multicenter clinical trial><Multisite clinical trial><NICHD><NIH><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><National Institutes of Health><Neonatal Research Network><Neonatology><Neural Development><Normal Placentoma><Observation research><Observation study><Observational Study><Observational research><Obstetric pharmacology><Obstetrics><Outcome><Participant><Pathology><Patient Care><Patient Care Delivery><Patients><Perinatal><Peripartum><Persons><Pharmaceutical Preparations><Placenta><Placenta Embryonic Tissue><Placentome><Population><Population Heterogeneity><Postpartum Period><Pregnancy><Productivity><Proteomics><Protocol><Protocols documentation><Provider><Publications><Qualifying><Race><Races><Randomization trial><Recovery><Research><Research Infrastructure><Research Personnel><Research Resources><Research Specimen><Research Support><Researchers><Resources><Safety><Saints><Scientific Publication><Services><Site><Socio-economic status><Socioeconomic Status><Specimen><Standardization><Structure><Supervision><System><Translational Research><Translational Science><Treatment Efficacy><United States National Institutes of Health><Universities><University Hospitals><care for patients><care of patients><caring for patients><clinical care><clinical center><clinical practice><death among infants><death in first year of life><death in infancy><death in infants><disparity in health><dissemination of results><diverse populations><drug safety><drug/agent><eligible participant><enroll><evidence base><experience><health disparity><heterogeneous population><high risk><imaging><improved><infant death><infant demise><infant morbidity><infantile death><innovate><innovation><innovative><intervention efficacy><lactating><lactational><long-term followup><long-term study><longitudinal outcome studies><longterm followup><longterm study><low birth weight><low birthweight><maternal death><medication safety><mortality in infants><multidisciplinary><neurodevelopment><next generation><obstetric care><operation><operations><patient population><personnel><pharmaceutical safety><population diversity><post-partum><pregnant><premature><prematurity><racial><racial background><racial origin><randomized trial><recruit><service delivery><skills><socio-economic position><socioeconomic position><success><therapeutic efficacy><therapy efficacy><translation research><translational investigation><trial design><under served community><underserved community>