Document text
Principal Investigator: Xiang Zhang
Organization: UNIVERSITY OF LOUISVILLE
Fiscal Year: 2024
Award: $298,524
Funding agency: National Institute on Alcohol Abuse and Alcoholism
The primary function of OMICS Core is to provide members of the University of Louisville Alcohol Research
Center (ULARC) with the expertise, resources, and facilities needed for metabolomic, proteomic, and
bioinformatic analyses of biological samples collected to study nutrition, gut flora/intestinal dysfunction and
alcohol-induced organ injury, and therapeutic interventions. OMICS Core personnel will assist with the design
of sample collection protocols, will drive the development and the execution of novel and robust
chromatographic methods for sample separation and mass spectrometric methods for the analysis of proteins,
peptides and metabolites with a goal of providing a greater understanding of the evolution of molecular
mechanisms that correlate with or participate in liver dysfunction. OMICS Core will ensure uniformity and
standardization in sample preparation, method development, instrument performance, data collection, data
reporting, and data sharing. OMICS Core endeavors to contribute to the overall success and utility of the
ULARC and to enhance the infrastructure and the technical and academic capabilities of the institution as a
whole. OMICS Core will also promote the education and training of the ULARC members with regards to the
state-of-the-art omics technologies. Furthermore, OMICS Core will become an independent and self-
supporting entity using a set comprehensive approaches that have been already been implemented and have
demonstrated their success in our current ULARC. The OMICS Core is projected to provide necessary and
essential support to all ULARC projects.
Terms: <Absolute ethanol><Acetylation><Active Follow-up><Affinity><Alcohol Chemical Class><Alcohol associated hepatitis><Alcohol hepatitis><Alcohol induced hepatitis><Alcohol related hepatitis><Alcoholic Hepatitis><Alcoholic Liver Diseases><Alcohols><Analytic Chemistry><Analytical Chemistry><B wadsworthia><B. wadsworthia><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Bilophila wadsworthia><Bio-Informatics><Bioinformatics><Biological><Biometrics><Biometry><Biostatistics><Blood Plasma><Broccoli><Broccoli - dietary><Butyrates><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cecum><Chromatography><Class Switching><Class Switchings><Complex Mixtures><Consumption><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data Collection><Data Reporting><Development><Dysfunction><ETOH><Education and Training><Enhancers><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethanol><Ethanol-induced hepatitis><Ethyl Alcohol><FOXP3><FOXP3 gene><Family><Feces><Forkhead Box P3><Functional disorder><GI microbiota><Gastrointestinal microbiota><General Transcription Factor Gene><General Transcription Factors><Ginger><Glutathione><Goals><Grain Alcohol><Heavy Drinking><Human><Human Resources><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-22><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immunoglobulin Class Switching><Immunoglobulin Class Switchings><Individual><Inflammatory><Infrastructure><Injury to Liver><Institution><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intestinal><Intestines><Investigators><Isotype Switching><Isotype Switchings><JM2><L rhamnosus><L-Tryptophan><L. rhamnosus><Lactobacillus casei rhamnosus><Lactobacillus rhamnosus><Levotryptophan><Lipids><Liver><Liver Dysfunction><Manpower><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mediating><Mediator><Methods><Methylcarbinol><Mice><Mice Mammals><Modern Man><Molecular Evolution><Monitor><Murine><Mus><Pathogenicity><Pathway interactions><Patients><Peptides><Performance><Phosphorylation><Physiopathology><Plasma><Plasma Serum><Play><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Preparation><Probiotics><Production><Protein Analysis><Protein Fragment><Protein Modification><Protein Phosphorylation><Proteins><Proteomics><Protocol><Protocols documentation><Reaction><Research><Research Personnel><Research Resources><Researchers><Resolution><Resources><Reticuloendothelial System, Serum, Plasma><Role><SCURFIN><STAT3><STAT3 gene><Sampling><Science><Short-Chain Fatty Acids><Stable Isotope Labeling><Standardization><T-Cells><T-Lymphocyte><Techniques><Technology><Testing><Therapeutic Intervention><Time><Tissue Sample><Training and Education><Transcription Factor Proto-Oncogene><Transcription factor genes><Translational Research><Translational Science><Tryptophan><Universities><Variant><Variation><Volatile Fatty Acids><Zingiber officinale><active followup><alcohol induced hepatic injury><alcohol induced liver disorder><alcohol induced liver injury><alcohol related liver disease><alcohol related research><alcohol research><alcohol-associated liver disease><alcohol-induced hepatic dysfunction><alcohol-induced liver disease><alcohol-induced liver dysfunction><alcohol-mediated liver dysfunction><alcohol-mediated liver injury><alcohol-related liver disease><alcoholic liver injury><bacteria pathogen><bacterial pathogen><biologic><bowel><broccoli sprout><data representation><data representations><data sharing><design><designing><determine efficacy><developmental><drink heavily><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enteric microbial community><enteric microbiota><epigenetically><ethanol induced hepatic injury><ethanol induced liver disorder><ethanol induced liver injury><ethanol liver disease><ethanol research><ethanol-induced hepatic dysfunction><ethanol-induced liver disease><ethanol-induced liver dysfunction><ethanol-mediated liver dysfunction><ethanol-mediated liver injury><evaluate efficacy><examine efficacy><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><exosome><extreme drinking><fecal sample><follow up><follow-up><followed up><followup><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><gastrointestinal microbial flora><gut commensal><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><heavy alcohol use><hepatic body system><hepatic damage><hepatic injury><hepatic organ system><inflammatory environment><inflammatory milieu><injury to organs><instrument><interleukin-22><intervention therapy><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><lipid mediator><lipidomics><liver damage><liver injury><member><metabolism measurement><metabolomics><metabonomics><method development><microbial><multidisciplinary><nano particle><nano-sized particle><nanoparticle><nanosized particle><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nutrition><organ injury><pathogenic bacteria><pathophysiology><pathway><personnel><preparations><prevent><preventing><protective effect><resolutions><sample collection><sex><social role><specimen collection><stool><stool sample><stool specimen><success><teratogenesis><thymus derived lymphocyte><transcription factor><translation research><translational investigation><treatment group>