Document text
Principal Investigator: David Kurtz
Organization: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Fiscal Year: 2024
Award: $2,300,332
Funding agency: National Institute of Environmental Health Sciences
The Quality Assurance Laboratory (QAL) in the Comparative Medicine Branch at the National Institute of Environmental Health Science (NIEHS)performs testing on the microbiological and/or chemical contamination of critical aspects of the overall NIEHS research program. Our primary task is monitoring the animal research program for microbiological and/or chemical contamination that may affect animal health and welfare, as well as, the physiological responses of animals used in research studies.
Our research focuses on the physiological effects of natural or contaminating microorganisms or compounds in the micro-environment (e.g., animal feed, caging, bedding, water, etc.)of the research animals. Our goal is to assure that we minimize exposure to environmental compounds that may effect animal health and welfare or alter physiological responses of the animals resulting in unacceptable variability.
Historically, QAL studies have focused on the potential for endocrine-disrupting compounds EDCs) being present in the micro-environment of the research animals and the impact these compounds may have on study outcomes, especially reproductive development. We have shown that natural phytoestrogens (e.g., daidzein and genistein) present in commercially available rodent diets or added to diets free of these compounds or the presence of the mycotoxin, zearalenone can accelerate reproductive development in juvenile female mice.
The current studies being performed in QAL include the following:
1. The effects of irradiation on high-fat rodent diets.
2. Simplified methods for multiplexed detection of rodent pathogens.
Terms: <4',7-Dihydroxyisoflavone><Acceleration><Adolescent><Adolescent Youth><Adverse effects><Affect><American><Animal Experimental Use><Animal Experimentation><Animal Feed><Animal Research><Animals><Annual Reports><Beds><Biological><Chemicals><Clinical><Collaborations><Coronaviridae><Coronavirus><Crowns><Dehydrogenases><Diet><Disease><Disorder><Dryness><E coli><E. coli><Ecologic Systems><Ecological Systems><Ecosystem><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Environmental Exposure><Environmental Protection Agency><Escherichia coli><Exposure to><F-2 Toxin><F2 Toxin><Fats><Fatty acid glycerol esters><Female><Fungal Toxins><Genestein><Genistein><Genisteol><Goals><Health><Hydrogen Oxide><Laboratories><Laboratory Animal Science><Laboratory Study><Manuscripts><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medicine><Methods><Mice><Mice Mammals><Monitor><Multimedia><Multimedium><Murine><Mus><Mycotoxins><NIEHS><NIH><National Institute of Environmental Health Sciences><National Institutes of Health><Operon><Outcome Study><Oxidoreductase><Oxidoreductase Gene><PFAS><Pathogen detection><Physiologic><Physiological><Phyto-Estrogen><Phytoestrogens><Poly-fluoroalkyl substances><Prunetol><Publishing><Reductases><Research><Rodent><Rodentia><Rodents Mammals><Self-Help Groups><Shigella><Soil><Source><Sterilization><Students><Support Groups><Testing><Toxic effect><Toxicities><United States Environmental Protection Agency><United States National Institutes of Health><Universities><Water><Zearalenone><animal experimentations><animal food><biologic><comparative><corona virus><daidzein><diadzein><diets><endocrine disrupting compound><health science research><irradiation><juvenile><juvenile human><meeting><meetings><metabolism measurement><metabolomics><metabonomics><microorganism><mouse genome><multiplex detection><pan-genome><pangenome><pathogen><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><polyfluorinated alkyl substances><polyfluoroalkyl substances><programs><quality assurance><reproductive development><research study><response><self help organization><summer intern><summer internship><welfare>