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Principal Investigator: Douglas Carl Dean III
Organization: UNIVERSITY OF WISCONSIN-MADISON
Fiscal Year: 2024
Award: $1,773,841
Funding agency: National Institute on Drug Abuse
Project Summary/Abstract
Neurodevelopmental processes are shaped by dynamic interactions between genes and environments.
Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring
developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures
in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural
racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is
imperative that a normative template of developmental trajectories over the first 10 years of life be established
based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the
Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a
harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an
extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand
neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United
States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-NC
Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research
dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center
(HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high-
dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will
assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed
on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other
substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially,
ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman
with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally
similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC
will identify key developmental windows during which both harmful and protective environments have the most
influence on later neurodevelopmental outcomes. The large, multi-modal, longitudinal, and generalizable dataset
that will be produced for the first time by this study will provide novel insights into child development using state-
of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of
children across the nation.
Terms: <0-11 years old><0-4 weeks old><10 year old><10 years of age><2nd trimester><Address><Adverse Experience><Adverse event><Affect><Alcohol Chemical Class><Alcohols><Behavioral><Biological><Birth><Brain><Brain Nervous System><COVID-19><CV-19><Care Givers><Caregivers><Child><Child Development><Child Youth><Children (0-21)><Communities><Conceptions><Coronavirus Infectious Disease 2019><DNA><Data><Data Collection><Data Coordinating Center><Data Coordination Center><Data Set><Deoxyribonucleic Acid><Development><EEG><Electroencephalogram><Electroencephalography><Encephalon><Enrollment><Environment><Environmental Exposure><Environmental Hazards><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethics><Ethnic Origin><Ethnicity><Event><Exposure to><Feedback><General Population><General Public><Genes><Gestation><Goals><HEAL Initiative><Health><Helping End Addiction Long-term><Helping End Addiction Longterm><Helping to End Addiction Long-term><Helping to End Addiction Longterm><Human><Infant><Infant and Child Development><Infection><Investigators><Life><Link><Location><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malnutrition><Marijuana><Maternal Health><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Midtrimester><Modality><Modern Man><Monitor><Mothers><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neural Development><Newborn Infant><Newborns><Nuclear Magnetic Resonance Imaging><Nutritional Deficiency><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Outcome><Participant><Parturition><Persons><Physiologic><Physiological><Population><Pregnancy><Pregnant Women><Process><Protocol><Protocols documentation><Psychopathology><Public Health><Public Policy><Race><Races><Research><Research Design><Research Personnel><Researchers><Sampling><Second Pregnancy Trimester><Second Trimester><Severities><Shapes><Site><Speed><Stress><Structural Racism><Study Type><Time><Time Study><Tobacco><Toxicant exposure><Training><Undernutrition><United States><United States National Institutes of Health><Woman><Work><Zeugmatography><abnormal psychology><age 10 years><bear children><bearing children><biologic><care giving><caregiving><child bearing><childbearing><cohort><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><critical period><data integrity><data management and coordinating center><data management center><data standardization><data standards><design><designing><developmental><dietary deficiency><early experience><early life exposure><enroll><epigenetically><ethical><expectant mother><expecting mother><experience><exposed in utero><fetal exposure><hazard><high dimensional data><improved><in utero exposure><innovate><innovation><innovative><insight><intra-uterine environmental exposure><intrauterine environmental exposure><kids><malnourished><maltreatment><marihuana><maternal stress><mistreatment><multi-modality><multidimensional data><multidimensional datasets><multimodality><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neurological imaging><newborn child><newborn children><non-medical opioid use><nonmedical opioid use><novel><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><opiate misuse><opioid addiction><opioid dependence><opioid dependent><opioid misuse><postnatal><pregnant><pregnant mothers><prenatal><prenatal exposure><prenatally exposed><protective factors><psychologic><psychological><racial><racial background><racial origin><recruit><remote assessment><remote evaluation><socio-economic><socio-economically><socioeconomically><socioeconomics><sound><stem><stressed mothers><study design><substance use><substance using><ten year old><ten years of age><tool><toxic exposure><unborn><youngster>