Document text
Principal Investigator: Elizabeth C Bryda
Organization: UNIVERSITY OF MISSOURI-COLUMBIA
Fiscal Year: 2024
Award: $1,300,192
Funding agency: NIH Office of the Director
Abstract (Overall)
The mission of the Rat Resource and Research Center (RRRC) is to provide biomedical investigators with the
rat models, embryonic stem cells, related reagents, protocols, information, support and services that will facilitate
their research. The RRRC serves as a unique repository by importing, storing and distributing a large number of
rat strains/stocks. It assures that valuable models are preserved and made available to interested investigators,
allows researchers to satisfy NIH requirements for resource sharing, relieves individual investigators from the
burden of animal distribution and ensures that models are maintained with rigorous genetic quality control and
health monitoring to promote experimental rigor and reproducibility. Recent advances in genome editing
technologies are facilitating the ability to perform sophisticated genetic modifications in rats in order to study both
normal biological processes and disease states. As a result, the number of rat models and the number of
investigators using rat models for biomedical research is increasing and the RRRC, as one of the only centralized
repositories in the world will continue to serve a critical role for archiving and distributing these new models. To
improve repository functions, applied research to optimize methods for sperm cryopreservation and in vitro
fertilization in the rat will be undertaken and ongoing efforts to refine, generate and characterize new genetically
modified rat models needed by the research community will be performed. To expand the broad utility of the
RRRC, we will continue to serve as consultants to the community and we will increase our fee-for-services in
the areas of model generation, model characterization, colony management, cryopreservation and rederivation.
By providing accessible expertise to investigators working with rats and by expanding our available materials
and services, the RRRC will continue to serve as a much-needed “one stop” resource for investigators using rats
in biomedical research.
Terms: <Animal Model><Animal Models and Related Studies><Animals><Applied Research><Applied Science><Archives><Area><Behavioral><Biological Function><Biological Process><Biomedical Research><Body Tissues><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Color Karyotyping><Common Rat Strains><Communication><Communities><Consultations><Cryofixation><Cryopreservation><Cytogenetics><Derivation><Derivation procedure><Disease><Disorder><ES Cell Line><ES cell><Embryo><Embryonic><Embryonic Stem Cell Line><Ensure><Fee-for-Service Plans><Fees for Service><Fertilization in Vitro><Gene Modified><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic analyses><Goals><Health><Heart Vascular><Individual><Institution><Investigators><Knock-out><Knockout><Methods><Mice><Mice Mammals><Mission><Modeling><Modification><Monitor><Murine><Mus><NIH><National Institutes of Health><Physiology><Play><Process><Protocol><Protocols documentation><Quality Control><Rat><Rat Strains><Rats Mammals><Rattus><Reagent><Recombinant DNA Technology><Reproducibility><Reproductive Biology><Research><Research Personnel><Research Resources><Researchers><Resource Sharing><Resources><Rodent Model><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Spectral Karyotyping><Sperm><Sperm Motility><Sperm Preservation><Spermatozoa><Technology><Test-Tube Fertilization><Therapeutic><Time><Tissues><Toxicology><United States><United States National Institutes of Health><Vendor><assay development><biomedical resource><circulatory system><cold preservation><cold storage><consultation><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><cost effective><depository><drug development><embryonic progenitor><embryonic stem cell><functional improvement><gene modification><genetic analysis><genetically engineered><genetically modified><genome editing><genomic editing><human disease><human model><improve function><improved><improved functional outcomes><innovate><innovation><innovative><interest><microbial consortia><microbial flora><microbiota><microflora><model development><model developments><model of animal><model of human><model organism><mouse model><multispecies consortia><murine model><preservation><rat genome><repository><semen cryopreservation><service delivery><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><sperm cell><sperm cell cryopreservation><sperm cryopreservation><sperm freezing><sperm mobility><spermatozoa cryopreservation><stem><stem cell of embryonic origin><zoosperm>