Document text
Principal Investigator: Paule Joseph
Organization: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
Fiscal Year: 2024
Award: $80,796
Funding agency: National Institute on Alcohol Abuse and Alcoholism
We wrote our clinical protocol for submission to IRB soon. However, through collaborations with other investigators both intramural and extramural we have published a number of manuscripts regarding this topic.
The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms. In collaboration, we co-authored a manuscript that confirmed in an independent cohort that chemosensory deficits are the best predictor of serologic response among individuals infected with SARS-CoV-2 (Overdest et al., 2022). Using the Global consortium for chemosensory research (GCCR) cohort, we looked at quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19-related smell loss. At follow-up (median time since COVID-19 onset 200 days), 60% of women and 48% of men reported less than 80% of their pre-illness smell ability. Taste typically recovered faster than smell, and taste loss rarely persisted if smell recovered (Ohla et al., 2022). Prevalence of parosmia and phantosmia was 10% of participants in Survey 1 and increased substantially in Survey 2: 47% for parosmia and 25% for phantosmia. Persistent smell impairment was associated with more symptoms, suggesting it may be a key marker of long-COVID illness. Persistent qualitative smell symptoms are emerging as common long-term sequelae of COVID-19 infection. Thus, more research into treatment options is strongly warranted, given that even conservative estimates suggest millions of individuals may experience parosmia following COVID-19. Healthcare providers worldwide must be prepared to treat post-COVID-19 secondary effects on physical and mental health. Lastly, following up on our published results from 2020 & 2021 from the GCCR studies, we confirmed that COVID-19 affects taste independently of smell by conducting a chemosensory home test and online survey from a global cohort (Nguyen et al., 2023). Assessing the smell and taste intensity of household items is a promising, cost-effective screening tool that complements self-reports and helps to disentangle taste loss from smell loss. However, it does not replace standardized, validated psychophysical tests.
Expanding our contribution to COVID-19 effects on Alcohol Use Disorder, we co-authored a manuscript with Dr. Ramchandani that showed that COVID-related stressors disproportionately affected minority and vulnerable groups. Individuals who experienced multiple financial stressors had the greatest risk for negative health-related outcomes and may benefit from holistic interventions and community outreach. In short, the participants were 463 adults who completed the baseline assessment of the National Institute on Alcohol Abuse and Alcoholism COVID-19 Pandemic Impact on Alcohol Study from June 2020 to January 2022. Three analytic methods (continuous sum score, categorical grouping, and LCA) were applied to model 17 COVID-related stressors using cross-sectional data. Regression analyses indicated higher COVID-related stress and endorsement of four or more COVID-related stressors was generally associated with worse health-related outcomes. LCA revealed four classes: Class 1: Minimal COVID-Related Impact (51.6%); Class 2: Work Interruptions (24.8%); Class 3: Family/Friends Affected by COVID (14.5%); and Class 4: Serious Financial Stress (9.1%). Racial/ethnic minorities were more likely to be in Class 3, whereas individuals with more years of education and higher income were less likely to be in Class 4. Individuals with a history of alcohol use disorder were more likely to be in Classes 2 and 4. Compared with Class 1, Class 4 reported the highest levels of perceived stress, problematic alcohol use, anxiety symptoms, depressive symptoms, alcohol craving, loneliness, drinking to cope, and the lowest levels of physical, psychological, social, and environmental quality of life (Luk et al., 2023).
Intramurally, as discussed, we established collaborations during the COVID-19 pandemic. Patients with AUD are at higher risk of COVID-19. We began to evaluate the data collected in the natural history of the COVID-19 impact alcohol study led by Drs. Ramchandani and Diazgranados.
Terms: <0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><Active Follow-up><Address><Adult><Adult Human><Affect><Ageusia><Alcohol Chemical Class><Alcohol abuse><Alcohols><Altered Taste><Anhedonia><Anosmia><Biological><Biological Markers><COVID crisis><COVID epidemic><COVID infected patient><COVID pandemic><COVID patient><COVID positive patient><COVID-19><COVID-19 affected><COVID-19 associated stress><COVID-19 consequence><COVID-19 crisis><COVID-19 effect><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 impact><COVID-19 impacted><COVID-19 induced stress><COVID-19 infected patient><COVID-19 infection><COVID-19 pandemic><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><COVID-19 patient><COVID-19 period><COVID-19 positive patient><COVID-19 public health crisis><COVID-19 related risk><COVID-19 related stress><COVID-19 risk><COVID-19 risk factor><COVID-19 stress><COVID-19 virus><COVID-19 virus infection><COVID-19 years><COVID19 infection><COVID19 patient><COVID19 positive patient><COVID19 virus><CV-19><Chemicals><Child><Child Youth><Children (0-21)><Clinical Protocols><CoV-2><CoV2><Collaborations><Community Outreach><Coronavirus Infectious Disease 2019><Data><Distorted Taste><Dysgeusia><EXTMR><Eating Behavior><Economic Income><Economical Income><Education><Educational aspects><Emotional Depression><Esthesia><EtOH abuse><Extramural><Extramural Activities><Family><Financial Hardship><Food><Friends><Genetic><Grouping><Gustation><Health><Health Care Providers><Health Personnel><Healthcare Providers><Healthcare worker><History><Household><IRB><IRBs><Immune response><Immunological response><Impairment><Income><Individual><Individuals from minority><Individuals of minority><Infection><Inflammation><Institutional Review Boards><Interruption><Intervention><Intervention Strategies><Investigators><Irritants><Loneliness><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><Manuscripts><Measures><Mental Health><Mental Hygiene><Minority Groups><Minority People><Minority Population><Minority individual><Modeling><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Natural History><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological Manifestations><Neurological Signs and Symptoms><Neurons><Olfaction><Olfactory dysfunction><Outcome><PASC><Parageusia><Paraosmias><Participant><Patient Self-Report><Patients><Perception><Persons><Phenotype><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Prevalence><Psychological Health><Psychophysics><Public Health><Publishing><QOL><Quality of life><Recording of previous events><Regression Analyses><Regression Analysis><Regression Diagnostics><Reporting><Research><Research Personnel><Researchers><Resolution><Risk><Role><SARS Virus><SARS corona virus><SARS corona virus 2><SARS coronavirus><SARS-Associated Coronavirus><SARS-CO-V2><SARS-COVID-2><SARS-CoV><SARS-CoV-1><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 infected patient><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV-2 patient><SARS-CoV-2 positive patient><SARS-CoV2><SARS-CoV2 infection><SARS-Related Coronavirus><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Screening procedure><Self-Report><Sensation><Sensory><Serology><Severe Acute Respiratory Coronavirus><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Smell><Smell Perception><Standardization><Statistical Regression><Sum><Survey Instrument><Surveys><Symptoms><System><Taste><Taste Perception><Testing><Time><Variant><Variation><Vulnerable Populations><Woman><Work><Writing><Wuhan coronavirus><active followup><adulthood><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><alcohol co-abuse><alcohol craving><alcohol problem><alcohol use disorder><analytical method><anosphrasia><anxiety symptoms><anxious symptom><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><chronic COVID><chronic COVID-19><chronic COVID-19 sequelae><chronic novel coronavirus disease 2019><cohort><coping><coronavirus disease 2019><coronavirus disease 2019 consequence><coronavirus disease 2019 crisis><coronavirus disease 2019 effect><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 impact><coronavirus disease 2019 infected patient><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease 2019 public health crisis><coronavirus disease 2019 risk><coronavirus disease 2019 risk factor><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease infected patient><coronavirus disease pandemic><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 impact><coronavirus disease-19 pandemic><coronavirus disease-19 patient><coronavirus disease-19 virus><coronavirus infectious disease-19><coronavirus patient><cost effective><depression symptom><depressive><depressive symptoms><design><designing><drinking><effects following the COVID-19 pandemic><ethanol abuse><ethanol craving><ethanol use disorder><ethnic minority><exosome><experience><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><follow up><follow-up><followed up><followup><groupings><gustatory perception><gustatory processing><gustatory response><hCoV19><hazardous alcohol use><health care personnel><health care worker><health provider><health workforce><healthcare personnel><high risk><histories><home test><home-based test><host response><hyposmia><immune system response><immunoresponse><impact of the SARS-CoV-2 pandemic><improve symptom><incomes><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><interventional strategy><kids><lonely><long haul COVID><long haul COVID-19><long haul coronavirus disease><long haul coronavirus disease 2019><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-hauler COVID><long-hauler COVID-19><long-hauler coronavirus disease 2019><long-hauler syndrome><long-term COVID><long-term COVID-19><long-term coronavirus disease><long-term coronavirus disease 2019><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><longterm COVID><longterm COVID-19><longterm coronavirus disease><longterm coronavirus disease 2019><loss of smell><medical personnel><men><multi-modality><multimodality><nCoV2><nasal obstruction><neural manifestation><neural mechanism><neuromechanism><neuronal><odor perception><olfactory impairment><olfactory loss><olfactory perception><parosmia><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><perceived stress><perception of stress><persistent COVID-19><physical conditioning><physical health><post COVID syndrome><post COVID-19 sequelae><post COVID-19 syndrome><post acute COVID syndrome><post acute COVID-19><post acute COVID-19 syndrome><post acute SARS-CoV-2><post acute coronavirus disease 2019><post acute coronavirus disease 2019 syndrome><post acute coronavirus disease syndrome><post acute sequelae following COVID-19><post acute severe acute respiratory syndrome coronavirus 2><post coronavirus disease 2019 syndrome><post coronavirus disease syndrome><post-COVID><post-COVID-19><post-acute phases of COVID-19><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><post-coronavirus disease 2019><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><prolonged COVID-19 symptoms><psychologic><psychological><psychophysical><racial minority><reduced smell><research study><resolutions><response><risk associated with COVID-19><risk factor associated with COVID-19><risk factor related to COVID-19><risk related to COVID-19><screening tools><self-reported stress><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><severe acute respiratory syndrome-CoV><social><social role><stress due to COVID-19><stress perception><stressor><symptom improvement><symptomatic improvement><taste loss><taste processing><taste response><treatment provider><vulnerable group><vulnerable individual><vulnerable people><youngster>