Document text
Principal Investigator: Kristin R Krueger
Organization: RUSH UNIVERSITY MEDICAL CENTER
Fiscal Year: 2024
Award: $516,995
Funding agency: National Institute on Aging
ABSTRACT
Older Latinx adults in the US are at a greater risk of developing Alzheimer's disease (AD) and related
dementias (ADRD). They exhibit a faster cognitive decline than non-Hispanic whites. However, they remain
vastly underrepresented in research studies to characterize risk factors associated with progressive cognitive
decline. A better understanding of risk factors can provide better treatment and design appropriate preventive
strategies for older Latinx adults. Since older Latinx adults have a higher prevalence of cardiovascular risk
factors, their risk of developing ADRD is high in old age. Older Latinx communities were disproportionately
affected by the COVID-19 pandemic, which can increase their risk for neurological disorders. This UH2/UH3
cooperative agreement aims to engage and develop the infrastructure for a new Latinx cohort study with the
following aims: (1) build infrastructure, community outreach, and the external advisory board for a new Latinx
cohort; (2) develop ongoing engagement with the community and resource sharing plan; (3) collect data on
250 Latinx participants from East Side sampling frame; and (4) test the exploratory hypotheses that Latinx
participants have a higher prevalence of clinically diagnosed AD and MCI, and the impact of COVID-19 on AD
is more severe compared to non-Hispanic whites, and the ApoE4 association with clinical AD and MCI is the
same as NHW. The long-term objective is to perform a sizeable muti-ethnic study, combining the Latinx cohort
with our existing Chicago Health and Aging Project (CHAP), a population-based community study in four
neighborhoods with 10,801 participants with 63% non-Hispanic Black and 37% non-Hispanic white
participants. This UH2/UH3 proposal will add a new Latinx cohort in the East Side community of Chicago, with
over 60% Latinx. A multi-ethnic cohort will allow us to test several biological and psychosocial hypotheses of
high public health significance. The collection of biospecimens will also allow for testing further blood
biomarker hypotheses, developing an omics pipeline down the road, and providing additional infrastructure for
pathology studies in a population-based cohort study with minorities.
Terms: <21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD related dementia><ADRD><APOE e4><APOE-ε4><APOEε4><Address><Adult><Adult Human><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's diagnosis><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease diagnosis><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Behavioral><Biological><Biological Markers><Black><Black race><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><COVID-19><COVID-19 affected><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><COVID-19 outbreak><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><COVID19 outbreak><CV-19><Censuses><Chicago><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Studies><Collection><Communities><Community Outreach><Concurrent Studies><Cooperative Agreements><Coronavirus Infectious Disease 2019><Data><Data Collection><Death Rate><Dementia><Disturbance in cognition><Epidemic><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Event><Exhibits><Focus Groups><Future><Generalized Growth><Genetic><Goals><Grant><Growth><Health><Health Inequity><Health system><Height><High Prevalence><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Household><Impaired cognition><Incidence><Individual><Individuals from minority><Individuals of minority><Inequalities in Health><Inequities in Health><Infrastructure><Knowledge><Latine><Latinx><Latinx group><Latinx individual><Latinx people><Latinx population><Life Style><Lifestyle><Minority><Minority Groups><Minority People><Minority Population><Minority individual><NIH><National Institutes of Health><Neighborhoods><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Participant><Pathology><Perception><Persons><Phase><Population><Population Study><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Procedures><Protocol><Protocols documentation><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Racial Group><Recommendation><Research><Research Grants><Research Infrastructure><Research Project Grants><Research Projects><Research Resources><Resource Sharing><Resources><Risk><Risk Factors><SARS-CoV-2 outbreak><Sampling><Severe acute respiratory syndrome coronavirus 2 outbreak><Side><Spanish/English><Testing><Tissue Growth><U-Series Cooperative Agreements><United States National Institutes of Health><Update><Washington><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><bi-racial><bio-markers><biologic><biologic marker><biomarker><biracial><cardiovascular risk><cardiovascular risk factor><clinical diagnosis><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><cohort><community based organizations><community engagement><community organizations><coronavirus disease 2019><coronavirus disease 2019 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study><population-level study><primary degenerative dementia><psychologic><psychological><psychosocial><race based differences><race differences><race related differences><racial><racial background><racial difference><racial origin><racial population><racial subgroup><racially different><rate of infection><recruit><research study><senile dementia of the Alzheimer type><social><social determinants><sociodeterminant><studies of populations><study of the population><success><tool><web site><website><≥65 years>