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Brain Care Score strongly correlates with risk of cardiovascular disease and three most common cancers worldwide. https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/brain-care- score-correlates-cardiovascualar-disease-common-cancers-risk?utm_source 7. Nail-Beatty, O., O’Brien, K., Platt, M., et al. (2024). Brain health is essential for smooth economic transitions: Towards socio-economic sustainability, productivity and well-being. Brain Communications, 6(6), fcae360. https://doi.org/10.1093/ braincomms/fcae360 8. Lock S. L. (2023). The benefits of brain health to our economies. Nature Aging, 3(1), 1–2. https://doi.org/10.1038/ s43587-022-00302-z 9. Rost, N. S., Salinas, J., Jordan, J. T., et al. (2023). The brain health imperative in the 21st century – A call to action. Neurology, 101(13), 570–579. https://www.neurology.org/doi/10.1212/WNL.0000000000207739 10. Business Collaborative for Brain Health. (n.d.). A unified model for brain health. Retrieved October 31, 2025, from https://businessforbrainhealth.org/resources/unifiedmodelbrainhealth 11. Brassey, J., De Smet, A., Kothari, A., et al. (2021, August 2). Future-proof: Solving the adaptability paradox for the long term, McKinsey & Company. https://www.mckinsey.com/capabilities/people-and-organizational-performance/our- insights/future-proof-solving-the-adaptability-paradox-for-the-long-term 12. Dondi, M., Klier, J., Panier, F., et al. (2021, June 25). Defining the skills citizens will need in the future world of work. McKinsey & Company. https://www.mckinsey.com/industries/public-sector/our-insights/defining-the-skills-citizens-will- need-in-the-future-world-of-work; World Economic Forum. (2025). The future of jobs report 2025. https://www.weforum. org/publications/the-future-of-jobs-report-2025/ 13. Herbig, B., Coe, E., Enomoto, K., et al. (2025, September 22). The new case for brain health: Scaling interventions for health and economic growth. McKinsey Health Institute. https://www.mckinsey.com/mhi/our-insights/the-new-case-for- brain-health-scaling-interventions-for-health-and-economic-growth 14. Kessler, R. C., Berglund, P ., Demler, O., et al. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6), 593–602. https://doi. org/10.1001/archpsyc.62.6.593 15. Xiaopeng, Z., Jing, Y., Xia, L., et al. (2025). Global Burden of Alzheimer’s disease and other dementias in adults aged 65 years and older, 1991–2021: population-based study. Frontiers of Public Health, 13, 1585711 https://pubmed.ncbi.nlm. nih.gov/40666154/ 16. Moutinho, S. (2025). Women twice as likely to develop Alzheimer’s disease as men – but scientists do not know why. Nature Medicine, 31(3), 704–707. https://doi.org/10.1038/s41591-025-03564-3 17. Conde, D. M., Verdade, R. C., Valadares, A. L. R., et al. (2021). Menopause and cognitive impairment: A narrative review of current knowledge. World Journal of Psychiatry, 11(8), 412–428. https://pmc.ncbi.nlm.nih.gov/articles/PMC8394691/ 18. Pritschet, L., Taylor, C. M., Cossio, D., et al. (2024). Neuroanatomical changes observed over the course of a human pregnancy. Nature Neuroscience, 27, 2253–2260. https://doi.org/10.1038/s41593-024-01741-0 19. Castro-Aldrete, L., Greenfield, M., Smith, E., et al. (2025). Women’s brain health and brain capital. Nature Mental Health, 3, 488–497. https://doi.org/10.1038/s44220-025-00406-6 20. Fitzgerald, E., Hor, K., & Drake, A. J. (2020). Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences. Early Human Development, 150, 105190. https://doi. org/10.1016/j.earlhumdev.2020.105190 21. John, C. C., Black, M. M., & Nelson, C. A., III (2017). Neurodevelopment: The impact of nutrition and inflammation during early to middle childhood in low-resource settings. Pediatrics, 139(Supplement 1), S59–S71. https://doi.org/10.1542/ peds.2016-2828H 22. Franke, H. A. (2014). Toxic stress: Effects, prevention and treatment. Children, 1(3), 390–402. https://doi.org/10.3390/ children1030390 The Human Advantage: Stronger Brains in the Age of AI 28

The Human Advantage Stronger Brains in the Age of AI 2026