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Principal Investigator: Margaret Leighton McNairy
Organization: WEILL MEDICAL COLL OF CORNELL UNIV
Fiscal Year: 2023
Award: $124,224
Funding agency: National Heart Lung and Blood Institute
ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented
cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new
study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). The training also leverages four
currently funded CVD research projects in Haiti (Aims 2-5), and a funded CVD research project in Tanzania
(Aim 6). United States trainees will spend ~50-60% of their time at international research sites in Haiti and
Tanzania, which have onsite Weill Cornell faculty, long-standing international collaborators, and outstanding
environments for research training. The common theme of the projects is patient-oriented CVD research in the
areas of clinical epidemiology, clinical trials, CVD-infectious diseases, and implementation science. The
projects include:
1. Environmental lead exposure and CVD risk factors in Haiti
2. Clinical epidemiology of CVD risk factors, diseases, and poverty-related social determinants in Haiti
3. Randomized clinical trial of early hypertension treatment among persons living with HIV
4. COVID-19 and cardiac dysfunction
5. Implementation of hypertensive screening and management
6. Heart failure in Tanzania
The focus of research training will be on postdoctoral clinical investigators who have completed their advanced
degree training. Dr. McNairy has an impeccable history of excellence in research mentorship and serves in
leadership roles in the Weill Cornell Global Health Research Fellowship and the Weill Cornell Women in Global
Health Research Initiative. Trainees will be mentored by Dr. McNairy and will participate in research projects in
Haiti (Aims 1-5) and Tanzania (Aim 6). These six projects have both clinical and laboratory aspects and offer
trainees a broad research experience. Trainees learn through the conduct of their mentored research project
and the opportunity to interact with colleagues working on studies other than their own. The K24 award will
allow Dr. McNairy to decrease her administrative and clinical responsibilities and commit 50% effort to CVD-
related research and mentorship of US trainees. Her long-term goal is to build a world-class CVD global health
research and training program to improve CVD-related health outcomes among the world's poorest
populations.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adult><Adult Human><Amlodipine><Anti-Hypertensive Agents><Anti-Hypertensive Drugs><Anti-Hypertensives><Antihypertensive Agents><Antihypertensive Drugs><Antihypertensives><Apoplexy><Area><Assess implementation><Blood><Blood Pressure><Blood Reticuloendothelial System><Blood Screening><Brain Vascular Accident><COVID complications><COVID related complications><COVID-19><COVID-19 complications><COVID-19 related complications><COVID-19 virus><COVID19><COVID19 virus><CV-19><CV19><Cardiac><Cardiac Death><Cardiac infarction><Cardiovascular Diseases><Caring><Case-Base Studies><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Clinic><Clinical><Clinical Investigator><Clinical Trials><CoV-2><CoV2><Cohort Studies><Communicable Diseases><Communities><Concurrent Studies><Consumption><Data><Death><Development><Diabetes Mellitus><Diastolic Pressure><Diastolic blood pressure><Disease><Disorder><Dysfunction><Early treatment><Echocardiogram><Echocardiography><Environment><Event><Faculty><Family><Fellowship><Foundations><Functional disorder><Funding><Future><General Population><General Public><Goals><HIV><Haiti><Haitian><Health><Heart failure><History><Human Immunodeficiency Viruses><Hypertension><Hypotensive Agent><Hypotensive Drugs><Immune Cell Activation><Implementation assessment><Impoverished><Incidence><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Inflammation><International><Intervention><Intervention Strategies><K24 Award><Kidney Diseases><LAV-HTLV-III><Laboratories><Lead><Lead levels><Leadership><Learning><Long-term cohort><Longitudinal cohort><Longterm cohort><Lymphadenopathy-Associated Virus><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mentors><Mentorship><Mid-Career Clinical Scientist Award (K24)><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Myocardial Infarct><Myocardial Infarction><Myocardial depression><Myocardial dysfunction><NHLBI><NIAID><Na element><National Heart, Lung, and Blood Institute><National Institute of Allergy and Infectious Disease><Natural History><Nephropathy><Obesity><Outcome><Participant><Pb element><Pb levels><Persons><Physiopathology><Population><Postdoc><Postdoctoral Fellow><Poverty><Prevalence><Prevention><R-Series Research Projects><R01 Mechanism><R01 Program><RE-AIM><Randomization trial><Randomized><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recommendation><Recording of previous events><Renal Disease><Research><Research Associate><Research Grants><Research Project Grants><Research Projects><Research Training><Risk Factors><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Safety><Serology><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Severities><Site><Smoking><Sodium><Sodium Chloride><Source><Spottings><Stroke><TB infection><Tanzania><Testing><Time><Training><Training Programs><Transthoracic Echocardiography><Tuberculosis><Unhealthy Diet><United States><Urine><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus-HIV><Woman><Wuhan coronavirus><adiposity><adulthood><anti-hypertension><biobank><biorepository><blood Pb><blood lead><brain attack><cardiac dysfunction><cardiac failure><cardiac infarct><cardiovascular disease epidemiology><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder epidemiology><cardiovascular disorder risk><cardiovascular epidemiology><case-controlled studies><cerebral vascular accident><cerebrovascular accident><clinical epidemiology><clinical implementation><cohort><complications due to COVID-19><corona virus disease 2019><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><corpulence><design><designing><developmental><diabetes><disseminated TB><disseminated tuberculosis><drug adherence><drug compliance><early clinical trial><early phase clinical trial><early therapy><environmental Pb exposure><environmental exposure to lead><environmental lead exposure><evaluate implementation><evaluation of implementation><experience><global health><hCoV19><heart attack><heart dysfunction><heart infarct><heart infarction><heart sonography><heavy metal Pb><heavy metal lead><high blood pressure><histories><hyperpiesia><hyperpiesis><hypertension control><hypertension management><hypertension treatment><hypertensive><hypertensive disease><hypertensive disorder><immune activation><implementation evaluation><implementation science><improved><infection due to Mycobacterium tuberculosis><interventional strategy><kidney disorder><kidney dysfunction><lack of physical activity><lead in blood><lead level><level of lead><low income country><medication adherence><medication compliance><mortality><nCoV2><occupational exposure to lead><occupational lead exposure><pathophysiology><patient centered><patient oriented><patient oriented research><patient oriented study><physical inactivity><poor diet><post-doc><post-doctoral><post-doctoral trainee><prehypertension><premature><prematurity><primary outcome><programs><randomisation><randomization><randomized trial><randomized, clinical trials><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><renal disorder><renal dysfunction><research associates><salt><screening><screenings><social determinants><social role><sociodeterminant><standard care><standard treatment><stool sample><stool specimen><stroked><strokes><training opportunity><training project><tuberculosis infection><tuberculous spondyloarthropathy>