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Principal Investigator: Faye Norby
Organization: UNIVERSITY OF MINNESOTA
Fiscal Year: 2024
Award: $141,154
Funding agency: National Heart Lung and Blood Institute
PROJECT SUMMARY
Sudden cardiac arrest (SCA), a sudden catastrophic loss of the pulse, continues to be a major public health
issue. A proportion of SCA events occur in persons engaging in drug use and given that drug overdose
deaths are at unprecedented levels in the United States, the epidemiology of drug related SCA is changing
rapidly. Recognition and characterization of drug related SCA events is critical for accurate estimates of
mortality associated with drug use, and to inform public health measures, especially in the context of the
ongoing opioid epidemic. This proposed study will address several of the major knowledge gaps. This K01
Career Development Award leverages the existing infrastructure and clinical data archive of two ongoing
prospective community-based studies of SCA. Dr. Norby will use this data to examine the epidemiology of
SCA associated with drug use, with the overall goal of improving community-based approaches to SCA
prevention. This proposal aims to 1) identify opportunities that will improve survival from SCA in the
setting of drug use, and 2) identify substrate-trigger factors that initiate SCA in the presence of drug use.
Taken together, these aims will interface community-based surveillance and comprehensive investigative
reports to fill in the epidemiology and research gaps in SCA events related to substance use. To address
these research aims, Dr. Norby will assemble records and reports in these two communities for SCA cases
that have previously been excluded due to evidence of drug use. The overall goal of this K01 is to inform
a sequence of R series grants to further investigate the prediction and prevention of SCA, and to improve
survival after an SCA event related to drug use. With the support of this K01 award, Dr. Norby will be able
to pursue this goal and transition to independent investigator status through essential training and
mentorship. She will gain advanced training in 1) combining multimodal health records across systems
and extracting pertinent information; 2) pharmacoepi drug use research and analysis of drug-drug
combination; and 3) SCA mechanisms, SCA response and care, and additionally gain familiarity with
toxicology and autopsy reports. Cedars-Sinai Smidt Heart Institute provides the ideal infrastructure to
complete the research and training activities. Through the proposed research, training, and career
development Dr. Norby will gain the scientific and professional skills necessary to become a successful
independent investigator and lead a research program that advances the field of SCA associated with drug
use.
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