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Principal Investigator: KRISTA M PERREIRA
Organization: UNIV OF NORTH CAROLINA CHAPEL HILL
Fiscal Year: 2024
Award: $615,646
Funding agency: National Heart Lung and Blood Institute
Project Summary/Abstract
Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the U.S.
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanic/Latinos. SGM
inequities in cardiovascular disease (CVD) risk have been identified as early as young adulthood; and minority
stress has been identified as a potential moderator. Yet, small numbers of ethnic minority participants in SGM
studies have precluded examination of the intersections of sexual orientation, gender identity, and ethnicity.
We propose a cost-effective ancillary study that will leverage existing data from the parent Hispanic
Community Health Study/Study of Latinos (HCHS/SOL) while collecting new data on sexual orientation, gender
identity, stigma, discrimination, stress, coping, social support, and CVD risk. The proposed study is timely
because HCHS/SOL participants will be scheduled for their third in-person visits (V3) starting in November
2019. In this study, we will (1) examine the influence of sexual orientation and gender identity on CVD risk
among all HCHS/SOL participants at V3 (~9300); (2) model pathways from sexual orientation and gender
identity to CVD risk through stigma, discrimination, and stress among a 1:2 matched sub-cohort of SGM and
non-SGM participants at V3 (~1680); and (3) examine the influence of stigma/discrimination on sexual
orientation and CVD risk relationships among sub-cohort participants at V3. Data analysis will follow a
conceptual model derived from the LGBT Minority Stress Model in which excess stigma discrimination against
SGM leads to minority stress that increases CVD risk. In this model, coping and social support serve as
resilience factors that mitigate the impact of minority stress on CVD risk. Cross-sectional and longitudinal
regression models as well as structural equation models will be used to test these relationships. Understanding
the influence of stigma-induced stress on CVD risk among Hispanic/Latino SGM has significant implications for
the development of culturally-specific CVD risk reduction strategies. Study findings will be used to build on
identified Hispanic/Latino cultural strengths to inform adaptation and testing of family and community
acceptance interventions.
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Terms: <21+ years old><Acculturation><Address><Adult><Adult Human><Age><Ancillary Study><Attenuated><Cardiac Diseases><Cardiac Disorders><Cardiovascular Diseases><Chicago><Cognitive Discrimination><Communities><Country><Cultural Assimilation><Data><Data Analyses><Data Analysis><Development><Discrimination><Enrollment><Epidemiologist><Equation><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Face><Family><Funding Opportunities><Gender><Gender Identity><Gender and Sexual Minorities><Goals><HCHS/SOL Study><HCHS/SOL cohort><Health><Health Inequity><Heart Diseases><High Prevalence><Hispanic><Hispanic Community Health Study/Study of Latinos><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Immigrant><Inequalities in Health><Inequities in Health><Inequity><Intervention><Intervention Strategies><Knowledge><LGBT><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Length><Lesbian Gay Bi-sexual Transgender><Lesbian Gay Bisexual Transgender><Linear Regressions><Long-term cohort study><Longitudinal cohort study><Longterm cohort study><Methods><Modeling><Modification><Morbidity><Morbidity - disease rate><New York><Parents><Participant><Pathway interactions><Personal Satisfaction><Persons><Population><Psychometrics><Psychosocial Factor><Psychosocial Stress><Publications><Race><Races><Research><Research Support><Residencies><Risk Factors><Risk Reduction><Schedule><Scientific Publication><Scientist><Sex Orientation><Sexual Orientation><Sexual and Gender Minorities><Site><Social support><Stigmatization><Stress><Testing><Time><Visit><Youth><Youth 10-21><adult youth><adulthood><ages><attenuate><attenuates><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular health><cohort><coping><cost effective><culturally adapted intervention><culturally appropriate intervention><culturally centered intervention><culturally focused intervention><culturally informed intervention><culturally responsive intervention><culturally tailored intervention><data interpretation><developmental><disparity in health><effective intervention><eligible participant><enroll><ethnic minority><ethnic subgroup><ethnicity group><experience><faces><facial><gender minority><gender minority status><gender minority stress><health disparity><health inequalities><heart disorder><innovate><innovation><innovative><instrument><intersectionalities><intersectionality><interventional strategy><minority stress><mortality><multidisciplinary><parent><pathway><psychosocial variables><public health relevance><racial><racial background><racial minority><racial origin><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resilience factor><resiliency factor><risk-reducing><sex><sexual disparity><sexual minority><social><social stigma><social support network><stigma><stress among minorities><stress in minorities><stress to minorities><well-being><wellbeing><young adult><young adulthood>