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Principal Investigator: Aimin Chen
Organization: UNIVERSITY OF PENNSYLVANIA
Fiscal Year: 2024
Award: $1,128,534
Funding agency: National Institute of Environmental Health Sciences
Philadelphia Regional Center for Children's Environmental Health (PRCCEH) is a new children's center
which will provide the infrastructure to integrate CEH research expertise at University of Pennsylvania (Penn)
Perelman School of Medicine (PSOM), Children's Hospital of Philadelphia (CHOP), Drexel University, Temple
University, Thomas Jefferson University, Lehigh University, Franklin & Marshall College, Villanova University
and University of Delaware to improve children's health by reducing environmental exposures in early life
across our region. The Center will be led by Directors Rebecca Simmons, M.D., and Aimin Chen, M.D.,
Ph.D., and Deputy Director Marilyn Howarth, M.D. The mission of the PRCCEH is to disseminate children's
environmental health knowledge to health care providers, community members, and policy makers, to develop,
test and implement new translational products, and to engage researchers and community partners to make
policy, practice, and behavioral changes to reduce environmental exposures in early life. The vision and the
mission of the PRCCEH are oriented to the Philadelphia region to address pressing CEH issues. The Center
consists of 27 experts in pediatrics, epidemiology, occupational and environmental medicine, toxicology, social
ecology, implementation science, community engagement, risk communication, nursing, bioinformatics, and
other areas. The Center is comprised of an Administrative Core and Executive Committee, a Development Core,
and a Translation Core, and is advised by Internal Advisory Committee and Community Stakeholder Advisory
Committee. The Center will focus on four primary research and translation areas: a) Asthma prevention,
motivated by disparity of asthma hospitalization in Philadelphia and a Community Asthma Prevention Program
(CAPP) with more than 20 years of experience; b) Lead exposure and harm reduction, motivated by a disparity
in elevated blood lead levels in children <6 years of age at the population level; c) Air pollution, motivated by
high annual particulate matter and ozone pollution in Philadelphia-Reading-Camden Metropolitan Statistical Area
(among the 25 worst polluted areas in the U.S.); and d) Endocrine disrupting chemicals (EDCs), motivated
by increasing disease burden from EDC-related preterm birth, obesity and diabetes, and neurodevelopmental
disorders. The Center members are experienced in these translational areas and will achieve the following
Specific Aims in the next 5 years. Aim 1. Build the PRCCEH as a regional infrastructure center for CEH research
and translation; Aim 2. Expand PRCCEH membership and leverage institutional resources to promote CEH
translation; Aim 3. Nurture and mentor early stage investigators (ESI) in CEH research and attract established
environmental health (EH) scientists into CEH; Aim 4. Translate CEH research to community members and
stakeholders to improve children's health; Aim 5. Establish two pilot programs for CEH translation; Aim 6.
Provide efficient administrative services to facilitate research translation.
Terms: <0-11 years old><6 year old><6 years of age><Address><Administrative Efficiency><Advisory Committees><African American><Afro American><Afroamerican><Air Pollution><Area><Asthma><Behavioral><Bio-Informatics><Bioinformatics><Bionomics><Bronchial Asthma><Child><Child Health><Child Youth><Children (0-21)><Children's Hospital><Communication><Communities><Day center care><Delaware><Development><Diabetes Mellitus><Discipline of Nursing><Disparities><Disparity><Doctor of Medicine><Doctor of Philosophy><Ecology><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Endowment><Environmental Exposure><Environmental Health><Environmental Health Science><Environmental Medicine><Epidemiology><Exposure to Pb2+><Harm Minimization><Harm Reduction><Health Care Professional><Health Care Providers><Health Personnel><Health Professional><Healthcare Providers><Healthcare professional><Healthcare worker><High Prevalence><Hospital Admission><Hospitalization><Housing><Industrial Medicine><Infrastructure><Institution><Intervention><Intervention Strategies><Investigators><Lead><Lead levels><Life><M.D.><Mentors><Mission><Neurodevelopmental Disorder><Neurological Development Disorder><Nursing><Nursing Field><Nursing Profession><O3><Obesity><Occupational Health><Occupational Medicine><Occupational or Industrial Medicine><Ozone><Parents><Particulate Matter><Pb element><Pb exposed><Pb exposure><Pb levels><Pb2+ Exposure><Pb2+ exposed><Pediatric Hospitals><Pediatrics><Pennsylvania><Ph.D.><PhD><Philadelphia><Policy Maker><Policy Making><Pollution><Population><Premature Birth><Prematurely delivering><Preterm Birth><Prevention><Prevention program><Reading><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Schools><Scientist><Services><Sight><Task Forces><Testing><Toxicology><Translating><Translational Research><Translational Science><Translations><Universities><Vision><adiposity><advisory team><age 6 years><associate faculty><associate professor><asthma prevention><blood Pb><blood lead><burden of disease><burden of illness><catalyst><college><collegiate><community engagement><community partners><community-based partners><corpulence><developmental><diabetes><disease burden><ecological toxicology><endocrine disrupting compound><engagement with communities><environmental toxicology><epidemiologic><epidemiological><experience><exposed to lead><exposure to Pb><exposure to lead><health care personnel><health care worker><health knowledge><health provider><health workforce><healthcare personnel><heavy metal Pb><heavy metal lead><implementation science><improved><interventional strategy><kids><lead exposed><lead exposure><lead in blood><lead level><level of lead><medical college><medical personnel><medical schools><member><metropolitan><mid-career faculty><midcareer faculty><neurodevelopmental disease><parent><premature childbirth><premature delivery><preterm delivery><professor><programs><school of medicine><six year old><six years of age><social><translation><translation research><translational health research><translational health science><translational investigation><treatment provider><visual function><web site><website><youngster>