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Principal Investigator: Kristen Kraemer
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
Fiscal Year: 2024
Award: $162,680
Funding agency: National Center for Complementary and Integrative Health
PROJECT SUMMARY
This K23 award will support the candidate’s training and development for an independent clinical research
career focused on understanding mechanisms of mind-body exercise interventions to optimize them for health
behavior promotion in medical populations. BACKGROUND. Rates of physical inactivity are alarmingly high,
particularly in patients with cardiometabolic conditions. Mind-body exercise interventions are promising for
promoting physical activity because they engage key health behavior change processes. While the
multidimensionality of mind-body exercise interventions is a strength, it also poses challenges for
understanding how individual therapeutic components engage health behavior change processes.
Disentangling the relative contribution of therapeutic components is critical for optimizing mind-body exercise
interventions for physical activity promotion. SPECIFIC AIMS. Using metabolic syndrome as a model, the
proposed study aims to: (1) refine the content and procedures of a factorial design to dismantle two mind-body
exercise components, exercise and mindful attention, via feedback from focus groups with sedentary patients
with metabolic syndrome and an interdisciplinary expert panel; (2) evaluate the feasibility and acceptability of
the factorial design in a pilot RCT; and (3) explore within-group patterns of change in self-regulation,
cardiopulmonary physiology, and physical activity levels across three timepoints. TRAINING. The candidate
will receive training in three areas to develop expertise critical to her overall career goals: (1) optimization-
focused clinical trial design and implementation; (2) qualitative research and longitudinal data analysis
(mediation); and (3) cardiopulmonary physiology research. These training aims will be supported by vast
institutional resources, as well as coursework, trainings, research seminars/meetings, and scientific
conferences. MENTORSHIP. The candidate will be supported by an expert mentoring team: Gloria Yeh, MD,
MPH (primary mentor), Peter Wayne, PhD (co-mentor), Long Ngo, PhD (collaborator), Chung-Kang Peng, PhD
(collaborator), Daniel Forman, MD (consultant), Erick Loucks, PhD (consultant), and Karen Kilgore, PhD
(consultant). IMPACT. In line with NCCIH priorities, skills acquired through this K23 proposal will promote an
independent research career focused on understanding how mind-body exercise interventions promote health
and optimizing these interventions to foster health promotion. While initial studies will focus on metabolic
syndrome and physical activity engagement, findings from this project will allow the candidate to develop a
model to study mind-body exercise for other medical populations known to struggle with initiating and
sustaining healthy behaviors. This K23 award will provide preliminary data for a R61/R33 application to
examine relative contributions of mind-body exercise components on health behavior change processes and
whether changes in these processes lead to downstream improvements in physical activity engagement.
Terms: <Adherence><Affect><Area><Attention><Awareness><Behavior><Breathing><Cardiac Chronotropism><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiopulmonary><Cardiopulmonary Physiology><Clinical Research><Clinical Study><Clinical Trials Design><Data><Data Analyses><Data Analysis><Development><Dimensions><Disease><Disorder><Doctor of Philosophy><Enrollment><Exercise><Feedback><Focus Groups><Fostering><Foundations><Future><Goals><Guidelines><Health Benefit><Health Promotion><Health behavior><Health behavior change><Heart Rate><Individual><Informal Social Control><Institution><Intervention><Intervention Strategies><Investigators><K23 Award><K23 Mechanism><K23 Program><Lead><Logistics><Mediation><Medical><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Metabolic syndrome><Methods><Modeling><NCCAM><NCCIH><National Center for Complementary and Integrative Health><National Center for Complementary and Integrative Medicine><Negotiating><Negotiation><Patients><Pattern><Pb element><Ph.D.><PhD><Physical Exercise><Physical activity><Physiologic><Physiological><Physiology><Pilot Projects><Population><Procedures><Process><Protocol><Protocols documentation><Qualitative Research><Randomized><Research><Research Design><Research Personnel><Research Resources><Researchers><Resources><Respiratory Aspiration><Respiratory Inspiration><Salutogenesis><Self Efficacy><Self Regulation><Study Type><T'ai Chi><Tai Chi><Tai Chi Chih><Tai Chi Chuan><Tai Ji><Tai Ji Quan><Tai Qi><TaiChi><Taiji><Taijiquan><Testing><Therapeutic><Time><Training><Work><Yoga><acceptability and feasibility><behavior change><cardiometabolic><cardiometabolic risk><cardiometabolism><cardiovascular risk><cardiovascular risk factor><career><conference><convention><cost><data interpretation><design><designing><developmental><emotion regulation><emotional regulation><enroll><exercise intensity><exercise intervention><health related behavior><heart rate variability><heavy metal Pb><heavy metal lead><improved><indexing><inspiration><interventional strategy><lack of physical activity><meeting><meetings><mind/body><mindfulness><multi-modality><multimodality><physical activity intervention><physical inactivity><pilot study><preference><promoting health><randomisation><randomization><randomly assigned><sedentary><skill acquisition><skill development><study design><summit><symposia><symposium><treadmill>