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Principal Investigator: SANDRA A BROWN
Organization: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Fiscal Year: 2024
Award: $524,097
Funding agency: National Institute on Alcohol Abuse and Alcoholism
PROJECT SUMMARY
Excessive alcohol drinking Initiated during adolescence is known to disturb typical neurodevelopmental patterns,
increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood.
In response to RFA-AA-21-008, the Administrative Resource (AR) proposes to coordinate activities of the
National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for
the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-
14, 15-17, 18-21 years old) as mostly no-to-low drinkers, tracked over the last 8 years across 5 sites (N=831;
93% retention rate). This consortium reflects seven applications: NCANDA - Administrative Resource (UCSD)
and NCANDA - Data Analysis Resource (SRI), and five cross-national Research Project Sites, located at Duke
University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International
(SRI), and UC San Diego (UCSD). Monitoring has involved annually multimodal neuroimaging (MRI, DTI, resting
state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by
computer and our mobile app. These measures will now be complemented with new advanced neuroimaging
and sleep and physical activity tracking. Our accelerated longitudinal design uniquely positions NCANDA-A
(ages 18-34) to quantify transient or enduring alcohol-related disturbances in adolescent and early adult neural
system growth trajectories and functional concomitants.
NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, we investigate
the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent
developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2
identifies the extent to which alcohol’s effects on brain structure and function resolve or persist during desistance
of binge drinking. Aim 3 identifies adolescent biological, environmental, and behavioral factors that forecast
excessive drinking during early adulthood. Aim 4 quantifies COVID-19 pandemic impact on alcohol use, stress,
and wellbeing. Aim 5 (SRI and Pittsburgh sites) identifies interactions among alcohol use, sleep, and cardiac
function. Aim 6 (UCSD, Duke and OHSU sites) determines the extent to which short-term (i.e., 4 weeks) alcohol
use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal
of structural and functional brain effects of binge alcohol use. For each aim, sex differences will be tested.
With longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel
information on the enduring and transient effects of adolescent drinking on adult functioning by discovering
elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.
Terms: <12-20 years old><21 year old><21 years of age><21+ years old><Acceleration><Active Follow-up><Acute><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Affect><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Authorship><Behavior><Behavioral><Biological><Brain><Brain Nervous System><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><Cardiac Chronotropism><Career Mobility><Clinical><Cognition><Cognitive><Communication><Communities><Computers><Conflict><Conflict (Psychology)><Data><Data Analyses><Data Analysis><Data Collection><Development><Differences between sexes><Differs between sexes><Disputes><Economics><Elements><Emotional><Encephalon><Ensure><EtOH abuse><EtOH drinking><EtOH use><Evaluation><Female><Functional MRI><Functional Magnetic Resonance Imaging><Gender><Generalized Growth><Goals><Growth><Health Sciences><Heart Rate><Heavy Drinking><Home><Independent Living><Individual><International><Interview><Leadership><Learning><Life><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory><Mission><Modeling><Monitor><NIAAA><NMR Imaging><NMR Tomography><National Institute on Alcohol Abuse and Alcoholism><Neural Development><Nuclear Magnetic Resonance Imaging><Oregon><Outcome><Patient Recruitments><Pattern><Performance><Personal Satisfaction><Persons><Physical activity><Policies><Position><Positioning Attribute><Procedures><Process><Protocol><Protocols documentation><Psychopathology><R-Series Research Projects><R01 Mechanism><R01 Program><Recovery><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resolution><Resources><Rest><Risk><Risk Factors><Sampling><Schools><Science><Sex Differences><Sexual differences><Sight><Site><Site Visit><Sleep><Sleep disturbances><Specialty><Standardization><Stress><Structure><Symptoms><System><Technology><Testing><Tissue Growth><Training><Trust><Universities><Vision><Work><Youth><Youth 10-21><Youth Drinking><Zeugmatography><aberrant sleep><abnormal psychology><active followup><addiction><addictive disorder><adolescence (12-20)><adolescent alcohol co-use><adolescent alcohol consumption><adolescent alcohol drinking><adolescent alcohol intake><adolescent alcohol use><adolescent drinking><adult youth><adulthood><age 21><age 21 years><ages><alcohol co-abuse><alcohol cue><alcohol during adolescence><alcohol effect><alcohol ingestion><alcohol initiation><alcohol intake><alcohol intake among adolescents><alcohol problem><alcohol product use><alcohol related cue><alcohol use><alcohol use among adolescents><alcohol use disorder><alcohol use during adolescence><alcohol use in adolescence><alcohol use in adolescents><alcohol use initiation><alcoholic beverage consumption><alcoholic drink intake><binge alcohol consumption><binge drinking><biologic><cardiac function><career><career advancement><career development><career transition><cognitive performance><cohort><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><cue reactivity><data interpretation><data standardization><data standards><design><designing><developmental><disrupted sleep><disturbed sleep><drink heavily><drinking><drinking during adolescence><drinking in adolescent><drinking initiation><early adulthood><economic><effects following the COVID-19 pandemic><emerging adult><emerging adulthood><episodic drinking><ethanol abuse><ethanol consumption><ethanol cue><ethanol drinking><ethanol during adolescence><ethanol effect><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><extreme drinking><fMRI><follow up><follow-up><followed up><followup><function of the heart><gray matter><hazardous alcohol use><hazardous drinking><heart function><heavy alcohol use><homes><impact of the SARS-CoV-2 pandemic><impaired sleep><improved><irregular sleep><juvenile><juvenile human><longitudinal design><male><malleable risk><medical specialties><meeting><meetings><mobile app><mobile application><mobile device application><modifiable risk><multi-modal neuro-imaging><multi-modal neuroimaging><multimodal neuro-imaging><multimodal neuroimaging><neural><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neurological imaging><novel><ontogeny><participant recruitment><post-pandemic><pre-pandemic><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><programs><prospective><resolutions><response><retention rate><retention strategy><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><sleep disruption><sleep dysregulation><social><substantia grisea><success><teen drinking><teenage alcohol use><teenage drinking><teenager alcohol use><twenty-one year old><twenty-one years of age><under age alcohol consumption><under age alcohol use><underage alcohol consumption><underage alcohol use><underage drinking><visual function><well-being><wellbeing><young adult><young adulthood><young man><young woman><youth alcohol co-use><youth alcohol consumption><youth alcohol use>