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Principal Investigator: Sophie Huddart
Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Fiscal Year: 2024
Award: $174,420
Funding agency: National Heart Lung and Blood Institute
PROJECT ABSTRACT
There is increasing recognition that post-tuberculosis (TB) lung disease (PTLD) is common and causes
significant morbidity and mortality. However, changes in lung impairment are heterogenous with some patients
improving and others worsening after completion of TB treatment. Moreover, spirometry – the standard method
of assessing lung function – is not routinely available in high TB burden countries. Thus, to prioritize post-TB
patients who may benefit from early interventions, there is an urgent need to better facilitate early identification
of patients at risk for developing PTLD.
The overall objective of this application is to evaluate novel approaches to facilitate early identification of patients
most at risk for PTLD. The central hypothesis is that patient on-treatment (adherence behavior) and novel post-
treatment (cough frequency and acoustic features) factors will improve risk stratification of PTLD. The central
hypothesis will be tested by pursuing three specific aims: 1) characterize the evolution of lung function post-TB
and its impact on health-related quality of life, 2) evaluate cough frequency and acoustic features measured by
a novel mobile app as a non-invasive, inexpensive proxy for spirometry, and 3) evaluate adherence and cough
feature trajectories as novel predictors of PTLD. The results of this work will provide preliminary data for an NIH
R01 application evaluating app-based cough measurement as a monitoring tool for rarer but serious post-TB
outcomes including COPD, TB recurrence and mortality.
Dr. Huddart’s career goal is to become an independent investigator focused on understanding drivers of poor
outcomes among TB patients in order to inform interventions to avert TB-related morbidity and mortality. To
support her path to independence, the proposed work will be paired with a dedicated, multidisciplinary
mentorship team and training in patient-centered outcomes assessment (Aim 1), machine learning (Aim 2), and
dynamic outcome modelling (Aim 3). UCSF is an outstanding environment that is committed to junior
investigators with extensive resources for research and career development. Thus, the K01 award will provide
Dr. Huddart with the critical mentorship, training, resources and experience to become an international leader in
TB outcomes research.
Terms: <Acoustics><Adherence><After Care><After-Treatment><Aftercare><Area><COPD><COVID-19><CV-19><Characteristics><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Clinical><Cohort Studies><Concurrent Studies><Coronavirus Infectious Disease 2019><Coughing><Country><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Dedications><Development and Research><Disease><Disease Frequency Surveys><Disorder><Drugs><Early Intervention><Early identification><Environment><Epidemiological data><Epidemiology data><Evolution><FEV1><FEV1%VC><Forced Expiratory Volume 1 Test><Forced Expiratory Volume in 1 Second><Frequencies><Future><Goals><Impairment><International><Intervention><Intervention Strategies><Investigators><K01 Award><K01 Mechanism><K01 Program><Life Cycle><Life Cycle Stages><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lung><Lung Diseases><Lung Respiratory System><Lung TB><Lung Tuberculosis><Lung symptom><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Machine Learning><Measurement><Measures><Medication><Mentored Research Scientist Development Award><Mentored Training Award><Mentorship><Methods><Modeling><Monitor><Monitoring for Recurrence><Morbidity><Morbidity - disease rate><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><NIH><National Institutes of Health><Obstruction><Outcome><Outcome Assessment><Outcomes Research><Output><PFT/FEV1><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Persons><Pharmaceutical Preparations><Predisposition><Prospective, cohort study><Proxy><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Function Test/Forced Expiratory Volume 1><Pulmonary TB><Pulmonary Tuberculosis><R & D><R&D><Recurrence><Recurrent><Research><Research Personnel><Research Resources><Research Scientist Development Award><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Risk><Risk Factors><Schedule><Site><Spirometry><Susceptibility><TB infection><TB therapy><TB treatment><Testing><Training><Treatment Factor><Treatment Period><Treatment outcome><Tuberculosis><United States National Institutes of Health><Visit><Work><behavior adherence><behavioral adherence><career><career development><chronic obstructive pulmonary disorder><chronic pulmonary disease><compliance behavior><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><design><designing><disease of the lung><disorder of the lung><disseminated TB><disseminated tuberculosis><drug adherence><drug compliance><drug/agent><epidemiologic data><experience><feature selection><health related quality of life><improved><improved outcome><infection due to Mycobacterium tuberculosis><interventional strategy><life course><lung disorder><lung function><machine based learning><medication adherence><medication compliance><mobile app><mobile application><mobile device application><mortality><multidisciplinary><new approaches><novel><novel approaches><novel strategies><novel strategy><outcome prediction><patient oriented outcomes><post treatment><pulmonary><pulmonary function><pulmonary symptom><research and development><respiratory><risk stratification><sound><stratify risk><tool><treat M. tuberculosis><treat Mtb><treat Mycobacterium tuberculosis><treat tb><treat tuberculosis><treatment adherence><treatment compliance><treatment days><treatment duration><tuberculosis infection><tuberculosis therapy><tuberculosis treatment><tuberculous spondyloarthropathy>