Uganda International Center for Excellence in Research
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Principal Investigator: Heinrich Feldmann Organization: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES Fiscal Year: 2020 Award: $66,415 Funding agency: National Institute of Allergy and Infectious Diseases Emerging/re-emerging zoonotic diseases are a major global health problem. Linking comprehensive pathogen surveillance of arthropod/vector populations in Uganda with public health surveillance at the regional and international level will make an important contribution to human and animal health in East Africa and the One World One Health concept in general. There will be a focus on rodent-borne pathogens potentially causing disease in humans, wildlife and livestock. A more comprehensive understanding of the ecology of known and unknown rodent-borne zoonotic pathogens is essential for a risk assessment for local and global human and animal health. The establishment of emerging/re-emerging virus program on the campus of the Uganda Virus Research Institute (UVRI), Entebbe, Uganda is ongoing. Rakai is no longer considered as a second program site. We have procured most of the necessary equipment for the UVRI site; further equipment will be purchased when needed. Over the previous and current funding period we have refined molecular and serological detection assays for several pathogens including arenaviruses, bunyaviruses, coronaviruses filoviruses, and flaviviruses. The ongoing SARS-CoV-2 pandemic and several ongoing outbreaks, such as the Ebola in the Democratic Republic of the Congo (DRC) and the ongoing Lassa fever outbreak in Nigeria, have delayed this project multiple times. Nevertheless, we continue to advance our molecular and serological assays that will be deployed to Uganda as soon as the lab space at UVRI is available and functional. Field work is now scheduled to start in the upcoming fiscal year. Terms: <2019 novel coronavirus><2019-nCoV><Africa><Animal Model><Animal Models and Related Studies><Animals><Arenaviridae><Arenavirus><Arenavirus group><Arthropod Vectors><Assay><Bacteria><Belgian Congo><Bioassay><Biologic Assays><Biological Assay><Bunyavirales><Bunyaviridae><Bunyavirus><Causality><Cell Culture System><Coronaviridae><Coronavirus><Data><Democratic Republic of the Congo><Detection><Development><Disease><Disease Outbreaks><Disorder><Ebola><Ecology><Education and Training><Environmental Science><Epidemiology><Equipment><Etiology><Farm Animal><Fever><Filoviridae><Filovirus><Flavivirus><Funding><Group B Arbovirus><Health><Human><In Vitro><International><Intervention><Intervention Strategies><Laboratories><Lassa Fever><Lassa disease><Link><Livestock><Microbiology><Modern Man><Modernization><Molecular><NIAID><National Institute of Allergy and Infectious Disease><Nigeria><Outbreaks><Population><Population Surveillance><Public Health Surveillance><Pyrexia><Research><Research Institute><Risk Assessment><Rodent><Rodentia><Rodents Mammals><Role><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Schedule><Serologic><Serologic tests><Serological><Serological Tests><Severe acute respiratory syndrome coronavirus 2><Site><Surveillance Program><Therapeutic><Time><Training and Education><Transmission><Uganda><Vaccines><Viral><Virus><Work><Wuhan coronavirus><Zaire><Zoonoses><Zoonotic><Zoonotic Infection><bacterial pathogen><base><causation><clinical relevance><clinically relevant><corona virus><developmental><disease causation><epidemiologic><epidemiological><febrile><febris><field based data><field learning><field study><field test><global health><in vivo><insight><international center><interventional strategy><model of animal><model organism><pandemic><pandemic disease><pathogen><pathogenic bacteria><post-graduate education><postgraduate education><programs><serology><social role><training opportunity><transmission process>