T cell responses in MIS-C related to SARS-CoV2

NIH Pandemic-Era Grants

Pandemic Era Grants

2021

↗ Live URL (may be dead)

Document text

Principal Investigator: Daniella  Schwartz
Organization: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Fiscal Year: 2021
Award: $42,081
Funding agency: National Institute of Allergy and Infectious Diseases

In FY2021, we continued exploring the responses of T cells from patients with MIS-C, using cells from age-matched subjects with acute SARS-CoV2 infection and age-matched healthy volunteers as comparators. Immunophenotyping began in FY2021 and is ongoing. 

Additionally, we have collaborated with colleagues at NIDDK to explore Vitamin-D-regulated T helper 1 function in SARS-CoV2 patients. 

Finally, we have initiated a collaboration to investigate the transcriptomes of adoptively transferred human COVID-specific T cells.

Terms: <0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Acute><Adoptive Transfer><Age><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><CITE sequencing><CITE-seq><CITEseq><COVID><COVID-19 infection><COVID-19 virus><COVID19 infection><COVID19 virus><Cell Body><Cell Function><Cell Process><Cell physiology><Cells><Cellular Function><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><CoV disease><CoV-2><CoV2><Collaborations><Dysfunction><Functional disorder><HPGF><Hepatocyte-Stimulating Factor><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immunes><Immunologic Subtyping><Immunophenotyping><Interleukin-6><MGI-2><MIS-C><Modern Man><Multiorgan Inflammatory Syndrome in Children><Multisystem Inflammatory Syndrome in Children><Myeloid Differentiation-Inducing Protein><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Pathogenicity><Patients><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Production><SARS corona virus 2><SARS-CoV-2><SARS-CoV-2 infection><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome related corona virus 2><Subcellular Process><Systems Biology><T cell response><T-Cells><T-Lymphocyte><VIT D><Vitamin D><Wuhan coronavirus><ages><base><cell age><cellular indexing of transcriptomes and epitopes by single cell sequencing><corona virus disease><coronavirus disease><coronavirus disease 2019 infection><coronavirus disease 2019 virus><cytokine><global gene expression><global transcription profile><hCoV19><healthy volunteer><immunophenotype><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><interferon beta 2><nCoV2><pathophysiology><pediatric inflammatory multisystem syndrome><response><thymus derived lymphocyte><transcriptome><youngster>