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Principal Investigator: JEFFREY Joseph ADAMOVICZ
Organization: UNIVERSITY OF MISSOURI-COLUMBIA
Fiscal Year: 2024
Award: $718,778
Funding agency: National Institute of Allergy and Infectious Diseases
Project Summary
Core 2: Biosafety Level 3 Practices
The Biosafety Level 3 Practices Core (BPC) at the Laboratory of Infectious Disease Research (LIDR)
includes three major components: Biosafety and emergency planning, user training and competency oversight,
and select agent program management. The BPC is integrated within the LIDR program and is positioned to
provide LIDR researchers from across campus with BSL-3 training and resources for working with BSL-3
pathogens. The LIDR is administered under the direction of the Division of Research, Innovation and Impact.
The goals of the BPC are to facilitate and support research by offering professional user training, scientific
procedural oversight, and to advise on all matters related to the scientific program including facility compliance
and safety. To achieve this goal, the BSL-3 Practices Core interfaces with all aspects of LIDR, including building
and facility infrastructure, security, laboratory practices, decontamination, and, importantly, the BPC oversees
the compliance of the BSL-3/select agent program as well as initial and ongoing training of its users. Towards
these goals, the LIDR Biosafety Level 3 Practices Core oversees compliance for working with select agents,
including the LIDR Personnel Suitability and Reliability Program (PSRP). For individuals cleared for entry into
the LIDR, the BSL-3 Practices Core will provide a comprehensive initial and ongoing competency-based training
program, and will be responsible for certifying the readiness of all individuals for entering BSL-3/ACL-3/ABSL-3
laboratories and associated support spaces. In addition, the BSL-3 Practices Core manages emergency
response planning, as well as drills, exercises and after-action reports, investigations and corrective action plans
for the BSL-3 program at LIDR. To maximize efficiencies and adoption of best practices, the BSL-3 Practices
Core is committed to workforce development by offering continuing education and certifications for
biocontainment professionals. Further, the BSL-3 Practices Core will work closely with Core 1 and Core 3 in this
UC7 project to train professional staff in the biosafety, biocontainment, and the safe operations of aerosol-
generating instrumentation. The BSL-3 Practices Core interacts closely with the Institutional Biosafety
Committee, Principal Investigators, the LIDR Operations Committee, and the RBL-NBL network to develop and
adopt best practice standard operating procedures and conduct risk assessments for all work associated with
BSL-3 pathogens. The BSL-3 Practices Core plays a central role in the pandemic preparedness and response
of the LIDR to facilitate its contributions to meeting the needs of emerging infectious diseases. Overall, the BSL-
3 Practices Core enables the work performed at LIDR, and assures that the BSL-3 Cores for the Facility
Operations and Research Resources can carry out their objectives for high containment research without
harming themselves, the environment or community.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Adopted><Adoption><Aerosols><Area><Attention><BSL-3 facility><BSL3 facility><Basic Research><Basic Science><COVID-19><COVID-19 virus><COVID19 virus><CV-19><Certification><CoV-2><CoV2><Common Rat Strains><Communicable Diseases><Communities><Competence><Complement><Complement Proteins><Containment><Continuance of education><Continuing Education><Core Facility><Coronavirus Infectious Disease 2019><Decontamination><Development and Research><Diagnostic><Emergencies><Emergency Situation><Emergency response><Emerging Communicable Diseases><Emerging Infectious Diseases><Environment><Equipment><Equipment and supply inventories><Exercise><Faculty><Faculty Recruitment><Failure><Family suidae><Goals><Grant><Grippe><Human Resources><Individual><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Infectious disease threat><Influenza><Infrastructure><International><Inventory><Investigation><Investigators><Investments><Laboratories><Location><Maintenance><Manpower><Methodology><Mission><Missouri><Modernization><Mutant Strains Mice><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Operations Research><Pigs><Play><Position><Positioning Attribute><Precision Health><Preparedness><Preventative strategy><Prevention strategy><Preventive strategy><Principal Investigator><Procedures><Productivity><Public Health><Public Health Schools><R & D><R&D><Rat><Rats Mammals><Rattus><Readiness><Reporting><Research><Research Personnel><Research Resources><Research Support><Researchers><Resource Development><Resources><Risk Assessment><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Safety><Science><Security><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Standardization><Students><Suidae><Swine><Teaching Hospitals><Testing><Training><Training Programs><Translational Research><Translational Science><United States National Institutes of Health><Universities><Vaccines><Variant><Variation><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Work><Workforce Development><Wuhan coronavirus><authority><base><bases><biocontainment facility><biocontainment lab><biocontainment laboratory><biosafety level 3 facility><complementation><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><emerging pathogen><hCoV19><improved><innovate><innovation><innovative><insight><institutional biosafety committee><instrumentation><interest><medical college><medical schools><meeting><meetings><mouse mutant><nCoV2><new pathogen><new technology><novel pathogen><novel technologies><operation><operations><pandemic containment><pandemic control><pandemic disease preparedness><pandemic mitigation><pandemic planning><pandemic preparedness><pandemic readiness><pandemic response><pathogen><personnel><porcine><priority pathogen><programs><recruit><recruit teachers><research and development><research facility><school of medicine><skills><social role><suid><teacher recruitment><translation research><translational investigation><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>