Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

NIH Pandemic-Era Grants

Pandemic Era Grants

2024

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Principal Investigator: Kyle Mitchell Hocking
Organization: VOLUMETRIX, LLC
Fiscal Year: 2024
Award: $1,000,000
Funding agency: National Heart Lung and Blood Institute

Project Summary
Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause
of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms;
laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment
of volume status. Using a unique physiologic signal, Non-Invasive Venous waveform Analysis
(NIVA), VoluMetrix has developed a proprietary device and algorithm designed for monitoring
volume status in HF patients. Proof of concept data in humans and experimental animal
models, demonstrate that NIVA provides a reliable indication of intravascular volume status
(“pulmonary capillary wedge equivalent”). The work in this Phase IIB proposal will establish
interface and usability studies to complete the process necessary for bridging the gap to
commercialization.

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