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Principal Investigator: Patricia Veronica Aguilar
Organization: UNIVERSITY OF TEXAS MED BR GALVESTON
Fiscal Year: 2021
Award: $300,959
Funding agency: John E. Fogarty International Center for Advanced Study in the Health Sciences
Abstract
Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in
Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most
low-and middle-income countries, only a handful of “dengue” cases are confirmed by laboratory testing and
therefore many other pathogens remain hidden under the dengue “umbrella”. Lack of proper training among
scientists and health care workers was recognized as one of the major obstacles in the diagnosis of AUFIs. To
fill this gap, our D43 Global Infectious Disease Research Training Program was launched in 2016, with the goal
of forming a strong team of scientists studying non-malarial acute undifferentiated febrile illnesses (AUFIs) in
Colombia. Since then, the program has filled a major gap. Over the past five years, we completed advanced
training of Colombian Faculty members, predoctoral and postdoctoral students, and conducted short-term
training on grant writing and manuscript preparation. The program encompassed short, medium, and long-term
research training, and it has exceeded expectations (see Progress Report). The past five years has allowed us
to identify additional gaps, challenges, and opportunities. Our new proposed activities will build on our
accomplishments and continue to build capacity and train a new group of Colombian Faculty members, PhD
students and postdoctoral fellows studying the emerging zoonotic and vector-borne diseases. We will expand
the focus of our D43 training program to address respiratory viruses, including SARS-CoV-2 and influenza
viruses. We will incorporate training of master’s students enrolled in the Master’s in Basic Biomedical Sciences
and implement training on novel molecular and bioinformatic methods, electron microscopy, novel diagnostic
methods, grant writing, scientific writing, ethics in scientific research, and biosafety, and for Colombian Faculty,
PhD students and postdoctoral fellows, research leadership. Our carefully designed plan includes: 1) In Years 1
and 2, we will support medium-term training of six Colombian Faculty members under a “train the trainer”
approach, 2) In Years 1 and 2, we will recruit and support in-country long-term training of master’s students
interested in emerging zoonotic and vector-borne diseases working under the mentorship of the Colombian
Program Faculty, 3) In Years 3 through 5, we will recruit and support long-term training of PhD, and postdoctoral
fellows in the US in advanced research methodologies, scientific writing, biosafety, and bioethics, and, 4) we will
conduct short-term in country training in Colombia to ensure appropriate implementation of methodologies, and
also conduct specific workshops. We will continue to support training across institutions in the region through in-
country visits of US Faculty members and funds will be available for pilot and reinsertion small grants after
completion of training. An important planned outcome is the increased awareness of these diseases at the level
of human and veterinary health professionals, as well as public health authorities.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Acute><Address><Awareness><Bio-Informatics><Bioethics><Bioinformatics><Biomedical Ethics><COVID-19 virus><COVID19 virus><CoV-2><CoV2><Colombia><Colombian><Country><Dengue><Diagnosis><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Disease><Disorder><Doctor of Philosophy><Educational workshop><Electron Microscopy><Enrollment><Ensure><Ethics><Faculty><Fever><Funding><Goals><Grant><Health Care Professional><Health Care Providers><Health Personnel><Health Professional><Healthcare Providers><Healthcare professional><Healthcare worker><Human><Incidence><Infectious Diseases / Laboratory><Infectious Diseases Research><Influenza Virus><Institution><LMIC><Laboratories><Latin America><Leadership><Manuscripts><Mentorship><Methodology><Methods><Modern Man><Molecular><Morbidity><Morbidity - disease rate><Outcome><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D.><Ph.D. student><PhD><PhD student><PhD. student><Postdoc><Postdoctoral Fellow><Preparation><Progress Reports><Public Health><Pyrexia><Research><Research Associate><Research Methodology><Research Methods><Research Training><SARS corona virus 2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Science><Scientist><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Students><Testing><Trainers Training><Training><Training Programs><Training Support><Undifferentiated><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Visit><Workshop><Writing><Wuhan coronavirus><Zoonoses><Zoonotic><Zoonotic Infection><authority><coronavirus disease 2019 virus><design><designing><doctoral student><enroll><ethical><expectation><febrile><febris><hCoV19><health care personnel><health care worker><health provider><health workforce><healthcare personnel><influenzavirus><interest><low and middle-income countries><medical personnel><member><mortality><nCoV2><new diagnostics><next generation diagnostics><novel><novel diagnostics><pathogen><post-doc><post-doctoral><pre-doc><pre-doctoral><predoc><predoctoral><programs><recruit><respiratory virus><treatment provider><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>