Document text
Principal Investigator: Lona Mody
Organization: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Fiscal Year: 2024
Award: $114,911
Funding agency: National Institute on Aging
ABSTRACT
Frail older adults in institutional settings such as hospitals and nursing homes (NHs) are at a particularly high
risk of poor outcomes. Translation of research findings into clinical practice, particularly in NHs, is
challenging. Educating and training a multidisciplinary group of junior investigators is key to designing
evidence-based, randomized studies to test innovative models and practices that reduce infections and
antimicrobial resistance in NH settings. In order to continue her well-established translational research, Dr.
Lona Mody, Amanda Sanford Hickey Professor of Internal Medicine at the University of Michigan, is
submitting this K24 renewal proposal. Dr. Mody’s career objective is to develop a nationally and internationally
recognized program in infection prevention among susceptible populations. She will achieve this objective by
conducting patient-oriented research that improves outcomes from infectious diseases and reduces
transmission of bacterial and viral infections in a vulnerable older population and by educating and training a
multidisciplinary group of mentees. The majority of her professional life has been dedicated to the conduct of
patient-oriented research. During the past 5 years, she has published 90 papers, including six articles
pertaining to career development and work-life balance. Fifty-three were as first or senior author (59% of 90)
and 59 publications were mentor/mentee collaborations (66% of 90). Several of her mentees have received
career development awards including GEMSSTAR, K awards and institutional career development grants
leading to independent academic careers and tenure track positions. She has established a steady stream of
research funding and effective mentorship, with continued collaboration throughout the course of mentees’
careers.
Dr. Mody’s research brings together expertise in geriatrics and aging research, microbiology and infectious
diseases, epidemiology, outcomes research, nursing, and others. Her work on reducing infections and
antimicrobial resistance in vulnerable populations grows out of work originally funded by the NIA, AHRQ,
CDC, T. Franklin Williams Scholarship (now known as GEMSSTAR), and the Hartford Foundation. Several
currently funded grants will serve as the platform for this grant proposal, including ongoing work funded by
NIH, AHRQ, VA, and the Kahn Foundation. These studies will yield rich datasets and banked microbes that
will be utilized to educate and train mentees in patient-oriented research with extensions to molecular
epidemiology and community-based participatory research. Resources supporting the education, training, and
development include the University of Michigan Medical School, VA Ann Arbor Healthcare System, UM
Department of Medicine, UM Department of Surgery, Michigan Institute for Clinical and Health Research
(MICHR, UM-CTSA), UM OAIC Pepper Center, and the UM School of Public Health.
Terms: <AHCPR><AHRQ><Accounting><Acute><Admission><Admission activity><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Aging><Airway infections><Antibiotic Therapy><Antibiotic Treatment><Antimicrobial Resistance><Applications Grants><Area><Bacterial Infections><COVID survivors><COVID-19 associated death><COVID-19 associated fatality><COVID-19 associated mortality><COVID-19 death><COVID-19 fatality><COVID-19 induced death><COVID-19 induced fatality><COVID-19 induced mortality><COVID-19 infection survivors><COVID-19 mortality><COVID-19 related death><COVID-19 related fatality><COVID-19 related mortality><COVID-19 survivors><COVID19 associated death><COVID19 associated fatality><COVID19 associated mortality><COVID19 death><COVID19 fatality><COVID19 induced death><COVID19 induced fatality><COVID19 induced mortality><COVID19 mortality><COVID19 related death><COVID19 related fatality><COVID19 related mortality><Capsicum><Cardiovascular Diseases><Career Choice><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Career Path><Caring><Clinical><Cognitive><Collaborations><Communicable Diseases><Data Banks><Data Bases><Data Set><Databanks><Databases><Dedications><Development><Diabetes Mellitus><Diagnostic><Discipline of Nursing><Education><Educational aspects><Environment><Environmental Pollution><Epidemiology><Event><Face><Faculty><Foundations><Frail Elderly><Frail Elders><Frail Older Adults><Frail Seniors><Funding><Geriatrics><Goals><Grant><Grant Proposals><Guidelines><Health><Health Care Costs><Health Care Professional><Health Care Systems><Health Costs><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Professional><Healthcare><Healthcare Costs><Healthcare Delivery><Healthcare Systems><Healthcare professional><High Prevalence><Hospitals><Host Factor><Host Factor Protein><Individual><Infection><Infection Control><Infection prevention><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Institution><Insurance><Integration Host Factors><Internal Medicine><International><Intervention><Intervention Strategies><Intervention Studies><Investigators><K-Awards><K-Series Research Career Programs><Lead><Length of Stay><Life><Link><Long-Term Care><MDR organism><MDR pathogen><Measures><Medicaid><Medicare><Medicine><Mentors><Mentorship><Metadata><Michigan><Microbe><Microbiology><Modeling><Molecular Epidemiology><Movement><NIH><Nasal><Nasal Passages Nose><National Institutes of Health><Nose><Number of Days in Hospital><Nursing><Nursing Field><Nursing Homes><Nursing Profession><Obesity><Older Population><Operative Procedures><Operative Surgical Procedures><Outcome><Outcomes Research><PASC><Paper><Patient Care><Patient Care Delivery><Patients><Patients' Rooms><Pb element><Persons><Pharyngeal structure><Pharynx><Population><Position><Positioning Attribute><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Precision Health><Predisposition><Prevent infection><Prevention program><Privatization><Public Health Schools><Publications><Publishing><QOC><Quality of Care><Randomized><Recreation><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resistance to infection><Resources><Respiratory Infections><Respiratory System, Nose, Nasal Passages><Respiratory Tract Infections><Risk><Role><SARS-CoV-2 associated death><SARS-CoV-2 associated fatality><SARS-CoV-2 associated mortality><SARS-CoV-2 death><SARS-CoV-2 fatality><SARS-CoV-2 induced death><SARS-CoV-2 induced fatality><SARS-CoV-2 induced mortality><SARS-CoV-2 infection history><SARS-CoV-2 mortality><SARS-CoV-2 related death><SARS-CoV-2 related fatality><SARS-CoV-2 related mortality><SARS-CoV-2 survivors><Safety><Sampling><Scholarship><Scientific Publication><Shapes><Stream><Structure><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><System><Testing><Throat><Title 18><Training><Training Programs><Translational Research><Translational Science><Transmission><Unemployment><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><United States National Institutes of Health><Universities><Variant><Variation><Viral><Viral Diseases><Virus Diseases><Visit><Vulnerable Populations><Work><acute care><adiposity><adverse consequence><adverse outcome><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><anti-microbial><anti-microbial resistant><antimicrobial><bacteria infection><bacteria pathogen><bacterial disease><bacterial disease treatment><bacterial infectious disease treatment><bacterial pathogen><body movement><cardiovascular disorder><care for patients><care of patients><career><career aspiration><career development><career interest><career life balance><career pathway><career track><caring for patients><chronic COVID-19 sequelae><clinical diagnostics><clinical practice><co-morbid><co-morbidity><cohort><community based participatory research><community led research><community participatory research><community partnered participatory research><comorbidity><coronavirus disease 2019 associated death><coronavirus disease 2019 associated fatality><coronavirus disease 2019 associated mortality><coronavirus disease 2019 death><coronavirus disease 2019 fatality><coronavirus disease 2019 induced death><coronavirus disease 2019 induced fatality><coronavirus disease 2019 induced mortality><coronavirus disease 2019 mortality><coronavirus disease 2019 related death><coronavirus disease 2019 related fatality><coronavirus disease 2019 related mortality><coronavirus disease-19 mortality><corpulence><data base><data depository><data repository><data set repository><dataset repository><death due to COVID-19><death due to COVID19><death due to SARS-CoV-2><death due to coronavirus disease 2019><death due to severe acute respiratory syndrome coronavirus 2><death in COVID><death in COVID-19><death in SARS-CoV-2><death in coronavirus disease><death in coronavirus disease 2019><death in severe acute respiratory syndrome coronavirus 2><design><designing><detection method><detection procedure><detection technique><developmental><diabetes><disability><environmental contamination><epidemiologic><epidemiological><evidence base><extended care><faces><facial><fatality due to COVID-19><fatality due to COVID19><fatality due to SARS-CoV-2><fatality due to coronavirus disease 2019><fatality due to severe acute respiratory syndrome coronavirus 2><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following infection by SARS-CoV-2><following severe acute respiratory distress syndrome CoV-2 infection><frail older adult><geriatric medicine><health and care delivery><health care><health care delivery><health care-associated infections><health delivery systems><health insurance for disabled><health services delivery><healthcare-associated infections><heavy metal Pb><heavy metal lead><high risk><history of COVID infection><history of COVID-19 infection><hospital days><hospital length of stay><hospital stay><improved outcome><indexing><infection management><infection resistance><innovate><innovation><innovative><intervention research><interventional research><interventional strategy><interventional study><interventions research><jobless><joblessness><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><longterm care><medical appointment><medical college><medical diagnostic><medical schools><meeting><meetings><meta data><microbiome><mortality due to COVID-19><mortality due to COVID19><mortality due to SARS-CoV-2><mortality due to coronavirus disease 2019><mortality due to severe acute respiratory syndrome coronavirus 2><multi-drug resistant organism><multi-drug resistant pathogen><multidisciplinary><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><next generation><novel><nursing home><older adult><older adulthood><older groups><older individuals><older person><out of work><participatory action research><pathogen><pathogenic bacteria><pathogenic virus><patient oriented research><patient oriented study><patient safety><pepper><population aging><post COVID-19 sequelae><post SARS-CoV-2 infection><post acute sequelae following COVID-19><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><professor><programs><randomisation><randomization><randomly assigned><rapid method><rapid technique><research study><resistance to anti-microbial><resistant to antimicrobial><respiratory><response><risk minimization><school of medicine><severe acute respiratory syndrome coronavirus 2 associated death><severe acute respiratory syndrome coronavirus 2 associated fatality><severe acute respiratory syndrome coronavirus 2 associated mortality><severe acute respiratory syndrome coronavirus 2 death><severe acute respiratory syndrome coronavirus 2 fatality><severe acute respiratory syndrome coronavirus 2 induced death><severe acute respiratory syndrome coronavirus 2 induced fatality><severe acute respiratory syndrome coronavirus 2 induced mortality><severe acute respiratory syndrome coronavirus 2 mortality><severe acute respiratory syndrome coronavirus 2 related death><severe acute respiratory syndrome coronavirus 2 related fatality><severe acute respiratory syndrome coronavirus 2 related mortality><social role><surgery><survive COVID-19><survive SARS-CoV-2><systemic barrier><systemic hurdle><systemic obstacle><tenure process><tenure track><translation research><translational investigation><transmission process><unemployed><viral infection><viral pathogen><viral transmission><virus infection><virus pathogen><virus transmission><virus-induced disease><vulnerable group><vulnerable individual><vulnerable people><work life balance>