Document text
Principal Investigator: Leonard A Jason
Organization: DE PAUL UNIVERSITY
Fiscal Year: 2022
Award: $200,734
Funding agency: National Institute of Neurological Disorders and Stroke
Abstract
This proposal would allow us to compare EBV and SARS-CoV-2 immune markers and metabolomics on the
samples from our unique data sets. Immune and metabolomic analyses are interesting discovery tools and an
important aspect of the integrative approach we will use, with their broad and flexible potential for studying
post-viral fatigue. We have also shown that college students with post-IM ME/CFS have an inflammatory
profile, even at baseline, different from those who recover from IM (Jason, Cotler, et al., 2021). In addition,
metabolomics has emerged as a novel tool for analyzing post-viral fatigue. Multiple studies have reported
detectable changes in metabolic pathways related to energy production, amino acids, nucleotides, nitrogen,
lipids, and neurotransmitters in patients with post-viral fatigue (Armstrong et al., 2014; Germain, Ruppert,
Levine, & Hanson., 2017; Nagy-Szakal et al., 2018; Naviaux et al., 2016). Our study of immunology and
metabolomics hopes to identify possible biosignatures for PASC and ME/CFS. Our primary aims are to
determine immunologic and metabolomic risk factors for the development of PASC following SARS CoV-2
infection and ME/CFS following IM. We hypothesize that altered host immune and metabolomic profiles will be
associated with post-viral fatigue following primary EBV and SARS-CoV-2 infection, in contrast to healthy
controls. In addition, qualitative in-depth interviews will explore perceptions of the following: major life
changes, fluctuations in employment status, changes in somatic symptoms, changes in coping strategies,
changes in physical and mental status, and the evolution of support systems, to determine which if any of
these factors are also important for the development and maintenance of PASC and ME/CFS.
Terms: <19 year old><19 years of age><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><3-10C><AMCF-I><Acute><Adolescent><Adolescent Youth><Age><Amino Acids><Attention><Attenuated><Behavioral><Biological><Biological Markers><Blood Plasma><Blood Serum><Blood leukocyte><Burkitt Herpesvirus><Burkitt Lymphoma Virus><CNS Nervous System><COVID-19 infection><COVID-19 positive><COVID-19 positivity><COVID-19 virus><COVID19 infection><COVID19 positive><COVID19 positivity><COVID19 virus><CXCL8><Central Nervous System><Cerebrospinal Fluid><Chicago><Children's Hospital><Chronic Fatigue Disorder><Chronic Fatigue Syndrome><Chronic Fatigue and Immune Dysfunction Syndrome><Chronic Fatigue-Fibromyalgia Syndrome><Chronic Infectious Mononucleosis-Like Syndrome><Climacteric><CoV-2><CoV2><Common Data Element><Comparative Study><Coping Skills><Data><Data Set><Dataset><Development><Diagnosis><E-B Virus><EB virus><EBV><Employment Status><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Epstein Barr Virus><Evolution><Fatigue><Freezing><GCP1><Glandular Fever><HHV-4><HHV4><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Human Herpesvirus 4><IL-8><IL8><IL8 gene><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Markers><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunochemical Immunologic><Immunodeficiency and Immunosuppression Disorders><Immunologic><Immunologic Diseases><Immunologic Markers><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunological response><Immunologically><Immunologics><Immunology><Incidence><Inducer Cells><Inducer T-Lymphocytes><Infection><Infectious Mononucleosis><Infectious Mononucleosis Virus><Inflammatory><Interview><K60><Lack of Energy><Leukocytes><Leukocytes Reticuloendothelial System><Lipids><ME/CFS><Maintenance><Marrow leukocyte><Metabolic Marker><Metabolic Pathway><Myalgic Encephalomyelitis><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Transmitter Substances><Network Analysis><Neuraxis><Neurotransmitters><Nitrogen><Nucleotides><Outcome><PASC><Participant><Pathway Analysis><Patient Self-Report><Patients><Pediatric Hospitals><Perception><Plasma><Plasma Serum><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Postviral Fatigue Syndrome><Principal Investigator><Production><Prospective Studies><Q Fever><Race><Racial Group><Racial Stocks><Reporting><Research><Reticuloendothelial System, Serum, Plasma><Risk Factors><Ross river virus><Royal Free Disease><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 infection><SARS-CoV-2 positive><SARS-CoV-2 positivity><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><SCYB8><Sampling><Self-Report><Series><Serum><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 positive><Severe acute respiratory syndrome coronavirus 2 positivity><Severe acute respiratory syndrome related corona virus 2><Social Support System><Students><Support System><Symptoms><Systemic infection><TSG-1><Testing><Time><United States National Institutes of Health><Viral Diseases><Virus Diseases><West Nile Virus Pathway><West Nile viral infection><West Nile virus infection><White Blood Cells><White Cell><Work><Wuhan coronavirus><Youth><Youth 10-21><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after severe acute respiratory distress syndrome CoV-2 infection><age 19 years><aged><ages><aminoacid><b-ENAP><base><bio-markers><biologic><biologic marker><biomarker><biosignature><cerebral spinal fluid><chronic COVID-19 sequelae><college><college student><collegiate><coping strategy><coronavirus disease 2019 infection><coronavirus disease 2019 positive><coronavirus disease 2019 positivity><coronavirus disease 2019 virus><coronavirus disease-19 virus><cytokine><developmental><epidemiologic investigation><epidemiology study><experience><flexibility><flexible><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following severe acute respiratory distress syndrome CoV-2 infection><hCoV19><host response><immune system response><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><inflammation marker><inflammatory environment><inflammatory marker><inflammatory milieu><juvenile><juvenile human><life change><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><mental state><mental status><metabolism measurement><metabolomics><metabonomics><mononucleosis><nCoV2><nineteen year old><nineteen years old><novel><post SARS-CoV-2 infection><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><psychologic><psychological><recruit><response><socio-demographics><sociodemographics><spinal fluid><tool><university student><viral infection><virus infection><virus-induced disease><white blood cell><white blood corpuscle>