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Principal Investigator: Holly Hagan
Organization: NEW YORK UNIVERSITY
Fiscal Year: 2024
Award: $341,921
Funding agency: National Institute on Drug Abuse
Project Summary/Abstract – Infectious Disease Epidemiology and Social-Behavioral Theory Core
The overarching goal of the Infectious Disease Epidemiology and Social-Behavioral Theory Core (IDEST) is to
support and train CDUHR investigators to apply theories and knowledge about multilevel factors, including
current large-scale trends and events that are affecting HIV transmission, natural history, prevention, and
clinical care, so that they are prepared to develop and carry out rigorous high-impact research that will
contribute to ending HIV among people who use drugs (PWUD). (We refer to these large-scale disruptive
trends and events as Big Events and Big Trends (BE/BT).) There has been a recent resurgence in new HIV
infections and outbreaks among PWUD in the US and abroad, and, in many settings, the COVID-19 pandemic
has generated the same circumstances that led to those outbreaks. This signals the need for a reinvigorated
HIV research agenda.
The IDEST Core has the following Specific Aims: 1) Encourage and support CDUHR investigators in applying
and integrating knowledge and theory about substance use and HIV epidemiology, prevention, and treatment
to enhance current studies and to develop and conduct new clinical, social-behavioral, and epidemiologic
research that will contribute to ending HIV in PWUD; 2) Provide training on multilevel factors that may promote
or impede ending HIV in the context of societal disruption, leading to studies that take these factors into
account; and 3) Lead the field in guiding a broad research and training agenda by developing and
disseminating relevant existing and new transdisciplinary theories and frameworks, with a focus on multilevel
and time-varying considerations generally and BE/BT in particular.
Core members are experts in the epidemiology, prevention, care and treatment of HIV infection and HIV-
related related co-morbidities, co-infections, and complications; in the study of substance use including
substance use disorders, and harm reduction; and in the development and use of relevant theories and novel,
theory-based metrics. All Core members have been highly productive in the field and within the Center. The
Core will provide training and consultation, and will take the lead within the Center on bringing emerging,
scientifically relevant issues, new theories, and advances in epidemiologic, biomedical and clinical aspects of
HIV and substance use to CDUHR investigators, with a focus on new and early stage investigators (new/ESI)
and underrepresented investigators. The IDEST Core will collaborate with other Cores and Center Leadership
to support CDUHR investigators to develop innovative high impact studies which will lead to new knowledge
related to the multilevel factors driving HIV among PWUD to guide interventions and policies promoting
progress toward eliminating HIV.
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