Document text
Principal Investigator: Ralph S Baric
Organization: UNIV OF NORTH CAROLINA CHAPEL HILL
Fiscal Year: 2024
Award: $136,801
Funding agency: National Cancer Institute
Abstract
The overall purpose of the FOA is to “establish Serological Sciences Centers of Excellence with the goal of
identifying and advancing research opportunities to characterize the immune responses elicited by SARS-CoV-
2 viral infection”. The “UNC Center for Excellence in SARS-CoV2 Serologic Research” addresses this RFA by
“performing basic and applied serological research to characterize the immune responses elicited by SARS-
CoV-2 viral infection, understand mechanisms driving the broad immune responses, determine modifiers of the
immune response and identify serological correlates of disease pathogenesis and protection against future
infection”. Administrative Core A is specifically responsive to this RFA in that it has been structured to manage
and coordinate all activities associated with our Center. In addition, Administrative Core A will serve as the liaison
between the all Centers for Excellence within the Serological Sciences Network (SeroNet) as well as other
components of SeroNet, including but not limited to Serological Sciences Research Projects (U01), the FNLCR
Serology Laboratory, Serological Capacity Building Centers (CBC) and a Serological Sciences Network
Coordinating Center (SSNCC). Administrative Core A will provide leadership, administrative support and
infrastructure for Research Projects 1, 2, and 3 (‘Project’) and two Shared Resource Cores B and C (‘Cores’).
Additionl responsibilities of our Administrative Core A include ensuring the data collected across the Program
conform with the agreed practice and principles of the SeroNet Standard Operating Procedures (SOPs),
Common Data Elements (CDEs) and data sharing plan as approved by the SeroNet Steering Committee. Thus,
as outlined in Fig 1 the Administrative Core A will 1: Fiscally Manage, Oversee, Facilitate and Evaluate Intra-
Program Collaboration Among Projects & Cores; 2: Provide Infrastructure for Human Cohort Recruitment,
Sample Collection, Tracking, & Sharing, 3: Develop Trans-SeroNet Collaborations and Collaborative Grants. As
outlined in the Overview the UNC Center Research Program Team is already highly intellectually and technically
integrated, building upon many multi-dimensional collaborations. As part of the Team structure, we have built
layers with distinct yet complementary roles and responsibilities which will promote integrated experimental
design, execution, and interpretation to address the current crisis and allow us to apply knowledge
collaboratively. This will be supported by a Translational Services Initiative which thus has the infrastructure
needed for recruiting sufficient patients and collecting samples necessary to support Projects 1-3 and Cores B
and C. In addition, it will result in a bio/data repository in which samples that span the course natural disease,
therapeutic interventions and potentially vaccination responses. In addition, our Program’s Annual Research
Retreats and our SeroNet Collaborative Pilot and Feasibility Grant Mechanism will connect and integrate our
Program, Projects and Cores with the broader SeroNet community further advancing research opportunities to
characterize the immune responses elicited by SARS-CoV-2 viral infection.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Agreement><Automobile Driving><COVID-19><COVID-19 virus><COVID19 virus><CV-19><Charge><Clinical><CoV-2><CoV2><Collaborations><Common Data Element><Community Networks><Consent><Coronavirus Infectious Disease 2019><Data><Data Banks><Databanks><Dimensions><Disease><Disorder><Enrollment><Ensure><Experimental Designs><Future><Goals><Grant><Human><Human Resources><IRB><IRBs><Immune response><Immunological response><Infection><Infrastructure><Institutional Review Boards><Knowledge><Laboratories><Leadership><Manpower><Modern Man><North Carolina><Pathogenesis><Patients><Procedures><Protocol><Protocols documentation><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Infrastructure><Research Project Grants><Research Projects><Resource Sharing><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Science><Serology><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Structure><Therapeutic Intervention><Vaccination><Viral Diseases><Virus Diseases><Wuhan coronavirus><cohort><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><data depository><data repository><data set repository><data sharing><dataset repository><design><designing><driving><enroll><hCoV19><host response><immune system response><immunoresponse><intervention therapy><nCoV2><personnel><programs><recruit><response><sample collection><social role><specimen collection><viral infection><virus infection><virus-induced disease>