Document text
Principal Investigator: Rachael Ann Clark
Organization: BRIGHAM AND WOMEN'S HOSPITAL
Fiscal Year: 2021
Award: $443,750
Funding agency: National Institute of Allergy and Infectious Diseases
SUMMARY
COVID 19, the lower respiratory disease caused by the 2019 nCov virus, is the latest betacoronavirus to cause
epidemic disease in humans. Previously, SARS and MERS, both cause by related viruses, emerged and fell
dormant as epidemics. Betacoronaviruses use homologous “Spike” proteins to bind mammalian cells for entry
and infection, and most vaccines are being built to generate neutralizing antibodies to the unique 2019 nCov
Spike protein. In contrast, we are trying to create a “universal” betacoronavirus vaccine base on T cell
immunity, using proteins conserved between all known coronaviruses as immunogens. These proteins,
expressed by MVA vectors and delivered by epidermal disruption, should provide broad and durable
pulmonary immunity to past, present, and future betacoronavirus threats.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV S protein><2019-nCoV spike glycoprotein><2019-nCoV spike protein><Antigens><Binding><Body Tissues><COVID-19><COVID-19 S protein><COVID-19 spike glycoprotein><COVID-19 spike protein><COVID-19 virus><COVID19><COVID19 S protein><COVID19 spike glycoprotein><COVID19 spike protein><COVID19 virus><CV-19><CV19><CoV-2><CoV2><Coronaviridae><Coronavirus><Disease><Disorder><Epidemic><Future><Generations><Human><Immunity><Infection><Lung><Lung Respiratory System><Lung diseases><MERS><MERS coronavirus disease><MERS-CoV disease><Mammalian Cell><Middle East Respiratory Syndrome><Middle East Respiratory Syndrome CoV disease><Middle East Respiratory Syndrome coronavirus disease><Middle Eastern Respiratory Syndrome><Middle Eastern Respiratory Syndrome CoV disease><Middle Eastern Respiratory Syndrome coronavirus disease><Modern Man><Molecular Interaction><Proteins><Pulmonary Diseases><Pulmonary Disorder><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><SARS><SARS corona virus 2><SARS coronavirus disease><SARS-CoV disease><SARS-CoV-2><SARS-CoV-2 S protein><SARS-CoV-2 spike glycoprotein><SARS-CoV-2 spike protein><SARS-CoV2><SARS-CoV2 S protein><SARS-CoV2 spike glycoprotein><SARS-CoV2 spike protein><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome coronavirus disease><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 S protein><Severe acute respiratory syndrome coronavirus 2 spike glycoprotein><Severe acute respiratory syndrome coronavirus 2 spike protein><Severe acute respiratory syndrome related corona virus 2><T memory cell><T-Cells><T-Lymphocyte><Tissues><Vaccines><Virus><Wuhan coronavirus><base><beta CoV><beta coronavirus><beta coronavirus vaccine><betaCoV><betacoronavirus><betacoronavirus vaccine><corona virus><corona virus disease 2019><coronavirus disease 2019><coronavirus disease 2019 S protein><coronavirus disease 2019 spike glycoprotein><coronavirus disease 2019 spike protein><coronavirus disease 2019 virus><dermal vaccination><design><designing><disease of the lung><disorder of the lung><epidermal vaccination><hCoV19><immunogen><lung disorder><lung pathogen><memory T lymphocyte><nCoV2><neutralizing antibody><new approaches><novel approaches><novel strategies><novel strategy><panbetaCoV vaccine><pulmonary><pulmonary pathogen><respiratory pathogen><skin vaccination><thymus derived lymphocyte><transdermal vaccination><vector><β CoV><β coronavirus><β coronavirus vaccine><βCoV>