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Principal Investigator: L Lee HAMM
Organization: TULANE UNIVERSITY OF LOUISIANA
Fiscal Year: 2023
Award: $9,304,973
Funding agency: NIH Office of the Director
Project Summary – Overall
The Tulane National Primate Research Center (TNPRC) is affiliated with Tulane University of Louisiana and
was dedicated in 1964. The Center is part of Tulane University Health Sciences along with the School of
Medicine, the School of Public Health and Tropical Medicine, and the School of Science and Engineering. The
TNPRC is one of seven NIH-supported National Primate Research Centers within the National Primate Research
Center Program. This application requests funding for the five-year time-period of May 1, 2023-April 30, 2028.
Funds will be used to support administration, operations, animal resources, scientific research resources, a pilot
research program, alteration and renovations, outreach, and education and training activities of the Center. The
animal resources program is fully accredited by AAALAC with exemplary status. Significant infrastructure
projects have been completed including renovation of new laboratory space and completion of the PET/CT
facility within the RBL. We have completed a large infrastructure upgrade with upgraded boilers and new and
increased capacity chillers, new building automation and access controls and energy efficiency lighting
upgrades, as well as upgrades in stormwater and wastewater treatment improvements.
The period since the last renewal of the TNPRC base grant has been a time of sustained growth and
programmatic change. Total funding for the Center has increased to more than $43.8M in FY2021. The TNPRC
is the only NPRC to have a Regional Biosafety Laboratory (BSL-3), which has been a key factor in obtaining
funds to support numerous studies utilizing select agents, tuberculosis, and emerging infectious diseases,
including a new and expanding program in SARS-CoV-2 research. Our efforts in SARS-CoV-2 have provided
leadership within the NPRC system with the development of nonhuman primate models, testing therapeutics
and vaccines. In addition, we developed a CoVID-19 Coordinating Center and Data Center supported by NIH,
which provides coordinated and collaborative interactions with other NPRCs. The development of our strong
Quality Assurance and Quality Control Program and new High Containment Research Performance Core have
contributed greatly to our success during this funding period. In the next grant period, we will recruit additional
faculty and expand our research efforts into chronic and comorbid conditions associated with infections and
aging. We will focus on building onto our current successes with the generation of a new strategic plan that will
make TNPRC the best primate center we can be and a premiere place to work for our employees.
Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><AIDS/HIV><Accreditation><Aging><Animal Model><Animal Models and Related Studies><Animals><Area><Automation><Award><Biomedical Research><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 infection><COVID-19 pandemic><COVID-19 public health crisis><COVID-19 virus><COVID-19 virus infection><COVID19><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 infection><COVID19 pandemic><COVID19 public health crisis><COVID19 virus><CV-19><CV19><Cellular Immunology><Chronic><CoV-2><CoV2><Communities><Containment><Contracting Opportunities><Contracts><Dedications><Development><Education><Education and Training><Educational aspects><Electronics><Emerging Communicable Diseases><Emerging Infectious Diseases><Employee><Engineering><Environment><Faculty><Funding><Generalized Growth><Generations><Grant><Growth><HIV/AIDS><Health><Health Sciences><Human><Illumination><Infection><Infrastructure><Institution><Investigators><Investments><Laboratories><Leadership><Lighting><Louisiana><Lung><Lung Respiratory System><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Methods><Mice><Mice Mammals><Mission><Modeling><Modern Man><Murine><Mus><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><NIAID><NIH><NIH RFA><National Institute of Allergy and Infectious Disease><National Institutes of Health><PASC><PET/CT><PET/CT scan><Pathogenicity><Performance><Play><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Postdoc><Postdoctoral Fellow><Primates><Primates Mammals><Private Sector><Public Health Schools><Quality Control><Request for Applications><Research><Research Associate><Research Personnel><Research Resources><Researchers><Resources><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV2><SARS-CoV2 epidemic><SARS-CoV2 infection><SARS-CoV2 pandemic><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Schools><Science><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Sight><Speed><Strategic Planning><System><TB infection><Technology><Therapeutic Studies><Therapy Research><Time><Tissue Growth><Training><Training Activity><Training and Education><Tropical Medicine><Tuberculosis><United States National Institutes of Health><Universities><Update><Vaccines><Vision><Work><Wuhan coronavirus><accredited><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><animal care><animal resource><applied biomedical research><applied biomedical sciences><aspirate><base><bases><biomedical resource><career development><chronic COVID-19 sequelae><co-morbid><co-morbidity><comorbidity><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><coronavirus infectious disease-19><data centers><developmental><disseminated TB><disseminated tuberculosis><diversity, equity, and inclusiveness><electronic><electronic device><empowerment><energy efficiency><equity, diversity, and inclusion><evaluate vaccines><evidence base><facilities for imaging><hCoV19><imaging center><imaging facilities><imaging-related facilities><improved><industrial partnership><industry partner><industry partnership><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><infection due to Mycobacterium tuberculosis><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><medical college><medical schools><model of animal><mouse model><murine model><nCoV2><non-human primate><nonhuman primate><ontogeny><operation><operations><outreach><positron emission computed tomography><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><post-doc><post-doctoral><post-doctoral trainee><programs><pulmonary><quality assurance><recruit><research associates><response><school of medicine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><sq. ft><square foot><success><therapeutic evaluation><therapeutic testing><training module><tuberculosis infection><tuberculous spondyloarthropathy><undergrad><undergraduate><undergraduate student><vaccine evaluation><vaccine screening><vaccine testing><visual function>