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Principal Investigator: KENNETH SEEDMAN KENDLER
Organization: VIRGINIA COMMONWEALTH UNIVERSITY
Fiscal Year: 2024
Award: $589,808
Funding agency: National Institute on Drug Abuse
Program Director/Principal Investigator: Kendler, Kenneth S
This second competitive renewal seeks to continue our innovative and productive research program which
seeks to understand the etiology of drug use disorders (DUD) utilizing data available on the entire population of
Sweden of unparalleled completeness and depth. We have eight specific aims: i) to use a newly developed
genetic risk score for DUD for the entire Swedish population to explore boundaries of the DUD phenotype,
model gene x environment interactions and clarify origins of DUD-related comorbidities; ii) to understand the
impact of social roles/relationships (e.g., marriage, divorce, parenthood) on risk and resilience for DUD; iii) to
explore the etiology of opiate use disorder (OUD) by comparing the social, familial and genetic risk factors
OUD and non-opiate DUD, by clarifying the etiologic role of opiate prescriptions in OUD development and to
identify clinically meaningful subtypes of OUD, especially an iatrogenic form; iv) to investigate the impact of
institutional settings on subsequent DUD, focusing on military service and incarceration; v) to evaluate the
impact of synthetically constructed populations compared to actual Swedish populations in the evaluation of
DUD and OUD utilizing FRED (A Framework for Reconstructing Epidemiological Dynamics) developed by our
collaborators at the Public Health Dynamics Laboratory (PHDL) at University of Pittsburgh; vi) to improve our
contagion models for the transmission of DUD by taking advantage of new data available in Swedish registries
on high school attendance, college attendance and workplace, improved Geographic Information Systems and
FRED; vii) to explore the association between stressful and traumatic events including COVID-19 exposure
severity and stress-related disorders (e.g., posttraumatic stress disorder [PTSD]) with DUD onset and
recurrence and examine moderators of impact of both exposures and stress-related disorders on DUD and viii)
using a calibrated, detailed version of the Swedish population in FRED, to evaluate the predicted impact of a
range of mitigation strategies, based on the relationships defined by our earlier work and new findings from the
above aims. We will, for many of these aims, attempt to clarify the causal nature of the observed associations
using statistical and natural experimental methods. We will use comprehensive data from multiple nationwide
data sources in Sweden on 11.8 million men and women to accomplish these goals. Applying the deep
expertise of our research groups at Virginia Commonwealth, PHDL and Lund University in drug abuse
research, social and genetic epidemiology, causal inference and epidemiological model development to a
uniquely powerful sample, we expect this study to have important implications for DUD research, prevention
and policy.
Terms: <Achievement><Achievement Attainment><Affect><Age><COVID-19><COVID-19 exposure><CV-19><Calibration><Causality><Characteristics><Clinical><Communicable Diseases><Communities><Community Services><Complex><Coronavirus Infectious Disease 2019><Country><Data><Data Sources><Developed Countries><Development><Diagnosis><Divorce><Divorced state><Drug Evaluation><Drug Evaluation Studies><Drug Use Disorder><Drug abuse><Drugs><Environment><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Family><Funding><Gene x Environment Interaction><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Risk><Genetic Susceptibility><Genetic predisposing factor><Genetic propensity><Geographic Information Systems><Geography><Goals><Grippe><GxE interaction><Iatrogenesis><Imprisonment><Individual><Industrialized Countries><Industrialized Nations><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Influenza><Inherited Predisposition><Inherited Susceptibility><Injury><Institution><Interpersonal Violence><Job Location><Job Place><Job Setting><Job Site><Joints><Laboratories><Link><Low Back Ache><Low Back Pain><Low Backache><Lumbago><Marriage><Married Persons><Measles><Medication><Methods><Modeling><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Natural experiment><Nature><Neighborhoods><Onset of illness><PTSD><Pain><Painful><Pathway interactions><Pattern><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Phase><Phenotype><Physical distancing><Policies><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Prevention><Principal Investigator><Probabilistic Models><Probability Models><Productivity><Public Health><Recurrence><Recurrent><Registries><Research><Research Resources><Resources><Risk><Role><Rubeola><SARS-CoV-2 exposure><SARS-CoV2 exposure><Sampling><Schools><Severe acute respiratory syndrome coronavirus 2 exposure><Severities><Social Distance><Source><Spouses><Statistical Models><Stressful Event><Students><Sweden><Syndrome><Transmission><Universities><Virginia><Woman><Work><Work Location><Work Place><Work-Site><Workplace><Worksite><abuse of drugs><abuses drugs><adverse childhood events><adverse childhood experiences><ages><causation><co-morbid><co-morbidity><college><collegiate><comorbidity><contagion><coronavirus disease 2019><coronavirus disease 2019 exposure><coronavirus disease-19><coronavirus infectious disease-19><developed country><developed nation><developed nations><developmental><disease causation><disease onset><disease risk><disorder onset><disorder risk><drug abuse prevention><drug addiction prevention><drug epidemiology><drug use prevention><drug/agent><environment effect on gene><environmental risk><epidemiologic><epidemiological><epidemiological model><exposure to COVID-19><exposure to SARS-CoV-2><exposure to SARS-CoV2><exposure to Severe acute respiratory syndrome coronavirus 2><exposure to coronavirus disease 2019><gene environment interaction><genetic epidemiologic study><genetic epidemiology><genetic etiology><genetic mechanism of disease><genetic risk factor><genetic vulnerability><genetically predisposed><geospatial information system><high risk><high school><iatrogenic><iatrogenically><iatrogenicity><improved><incarcerated><incarceration><information framework><inherited factor><injuries><innovate><innovation><innovative><licit opioid><men><military service><model development><model developments><model-based simulation><models and simulation><morbilli><opiate abuse><opiate drug abuse><opiate medication><opiate use disorder><opioid abuse><opioid drug abuse><opioid medication><opioid use disorder><pathway><pharmacoepidemiologic><pharmacoepidemiological><post-trauma stress disorder><posttrauma stress disorder><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent drug abuse><prevent drug addiction><prevent drug use><programs><progression risk><protective effect><protective factors><psychiatric co-morbidity><psychiatric comorbidity><resilience><resilient><social><social epidemiology><social influence><social role><statistical linear mixed models><statistical linear models><stress related disorder><stressful experience><stressful life event><stressful life experience><synthetic DNA><synthetic construct><synthetic data><tool><transmission process><traumatic event><traumatic neurosis><work setting>