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Principal Investigator: Bryan R Greenhouse
Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Fiscal Year: 2024
Award: $197,226
Funding agency: National Institute of Allergy and Infectious Diseases
Abstract
Dr. Greenhouse is a physician scientist trained in internal medicine, infectious diseases, and
biostatistics. Over the past 18 years, he has worked across domains of field epidemiology, laboratory science,
data science, and public health to investigate the epidemiology of infectious diseases, with a focus on disease
transmission and development of immunity. His growth as a scientist and mentor was substantially accelerated
due to the dedicated time afforded by his current K24. Studies to accomplish the research aims outlined in his
prior K24 application have all been published as peer-reviewed papers and/or are the subject of active, R01-
level NIH grants where he or a clinician scientist that he mentors serves as principal investigator. During this
project period he published 80 papers, was PI on 3 new grants including R01 and U01 awards from NIAID,
was co-investigator on 6 new grants, and was primary mentor for 2 new K awards. Regarding mentorship, he
supervised 39 trainees including 14 from low- or middle-income countries, cofounded the UCSF EPPIcenter as
a center of excellence for research and training in patient-oriented research, created two longitudinal training
programs in malaria genetic epidemiology for African scientists, and co-led 3 workshops in genomic
epidemiologic analysis for over 100 African scientists.
During the next K24 project period, Dr. Greenhouse proposes to 1) focus on leadership development so
he can better guide the growth and success of the EPPIcenter; 2) expand the scope of his research portfolio to
include pathogens beyond malaria and the addition of domestic research; and 3) establish an interactive,
online training platform in genomic epidemiologic analysis. He presents a plan for achieving these goals by
obtaining leadership development training, expanding his skill set in the epidemiology of respiratory viruses
and laboratory methods for multi-pathogen surveillance, and developing expertise in curricular development
and other principles such as the use of technology for effective teaching. Dr. Greenhouse’s existing research
portfolio provides a wealth of opportunities for trainees, including projects studying the longitudinal
development of naturally acquired immunity to malaria using birth cohorts to simultaneously study the
pathogen and the host; systems immunology and computational analysis to comprehensively characterize
factors associated with development of immunity to malaria; and an array of projects related to the genomic
epidemiology of malaria including multiple with explicit training and capacity building goals. He proposes to
expand the scope of his research portfolio with 3 specific aims: 1) to develop and apply amplicon sequencing
tools to solve current challenges in malaria surveillance; 2) to characterize the pathogen landscape of non-
malarial febrile illness in Uganda; and 3) to characterize the transmission of respiratory pathogens in an urban
immigrant community in San Francisco.
Terms: <Acceleration><Address><African><Algorithms><Anti-malarials><Area><Assay><Award><Bio-Informatics><Bioassay><Bioinformatics><Biological Assay><Biometrics><Biometry><Biostatistics><Birth><Blood><Blood Plasma><Blood Reticuloendothelial System><COBRE><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Career Choice><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Career Path><Case Management><Center of Biomedical Research Excellence><Centers of Research Excellence><Circulation><Cities><Classification><Clinical><Collaborations><Communicable Diseases><Communication><Communities><Community Health><Computer Analysis><Computerized Medical Record><Country><Data><Data Analyses><Data Analysis><Data Science><Dedications><Development><Economic Income><Economical Income><Educational process of instructing><Educational workshop><Electronic Medical Record><Enrollment><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology><Epidemiology Research><Fever><Functional Metagenomics><Funding><Future><Generalized Growth><Generations><Geography><Goals><Grant><Growth><Guidelines><Health><Health Facilities><Health care facility><Healthcare Facility><Household><Immigrant><Immigrant community><Immunity><Immunology><Income><Infectious Disease Epidemiology><Infectious Disease Pathway><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Infectious Epidemiology><Infrastructure><Internal Medicine><International><Intervention><Intervention Strategies><Investigators><K-Awards><K-Series Research Career Programs><K24 Award><K24 Mechanism><K24 Program><Laboratories><Learning><Longitudinal Studies><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malaria><Mentors><Mentorship><Metagenomics><Methods><Mid-Career Clinical Scientist Award (K24)><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><NGS Method><NGS system><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Paludism><Paper><Parturition><Peer Review><Physicians><Pilot Projects><Plasma><Plasma Serum><Plasmodium Infections><Population><Principal Investigator><Public Health><Publishing><Pyrexia><Research><Research Career Program><Research Personnel><Research Specimen><Researchers><Residual><Residual state><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Reticuloendothelial System, Serum, Plasma><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><San Francisco><Science><Scientist><Sentinel><Sentinel Surveillance><Sentinel Surveillances><Serology><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Specimen><System><Systematics><Teaching><Technology><Testing><Time><Tissue Growth><Training><Training Programs><Translational Research><Translational Science><Transmission><Treatment Efficacy><Uganda><United States National Institutes of Health><Work><Workshop><acquired immunity><analytical method><anti-malarial agents><anti-malarial drugs><burden of disease><burden of illness><burden of infection><care facilities><career><career aspiration><career development><career interest><career pathway><career track><cohort><communicable disease transmission><community-based health><computational analyses><computational analysis><computer analyses><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data interpretation><developmental><disease burden><disease transmission><efficacy study><enroll><epidemiologic><epidemiologic investigation><epidemiological><epidemiology study><experience><febrile><febris><field based data><field learning><field study><field test><flexibility><flexible><genetic epidemiologic study><genetic epidemiology><genomic epidemiology><improved><improved outcome><incomes><infection burden><infectious disease transmission><interdisciplinary approach><interest><intervention efficacy><interventional strategy><leadership development><long-term study><longitudinal outcome studies><longterm study><method development><multidisciplinary approach><new approaches><next gen sequencing><next generation><next generation sequencing><nextgen sequencing><novel approaches><novel strategies><novel strategy><ontogeny><pathogen><patient oriented research><patient oriented study><pilot study><programs><public health intervention><respiratory pathogen><respiratory virus><response><serology surveillance><serosurveillance><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><success><therapeutic efficacy><therapy efficacy><tool><translation research><translational investigation><translational investigator><translational researcher><translational scientist><transmission process>