Document text
Principal Investigator: Carina Marquez
Organization: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Fiscal Year: 2024
Award: $675,457
Funding agency: National Institute of Allergy and Infectious Diseases
PROJECT SUMMARY/ABSTRACT
The burden of tuberculosis (TB) in children and adolescents is massive and current TB control strategies, even
at full scale-up, are insufficient to address it.4,6-8,10 Novel strategies to expand TB control outside of the home
and into the community, where children acquire an estimated 80% of new TB infections,11-12 are urgently
needed. However, an incomplete understanding of where and from whom youth acquire TB, and how these
drivers change throughout the early life-course, hampers the design of novel interventions. Thus, we propose
the first-ever population-representative, longitudinal TB Infection Incidence Cohort of youth ages 1 to 18 years,
in rural communities in Uganda. Using a combination of epidemiologic and network analytic techniques, this
study will address key foundational knowledge gaps about TB transmission within 3 socio-spatial networks of
youth: the household network, the non-household social network (close contacts), and the network of casual
contacts encountered in community venues. In Aim 1 we will characterize the role of the household social
network in TB infection throughout the early life course. In Aim 2 we will employ social network analysis to
assess the relationships between child and adolescent TB infections and their community-based social
network, and in Aim 3 we will use location-based networks to assess the relationships between community
venues and incident TB infections in youth. Data from this proposal will directly inform novel, age-specific,
community-based TB control strategies and will help optimize existing household-based strategies.
Terms: <0-11 years old><12-20 years old><17 year old><17 years of age><21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Age Years><Aged 65 and Over><Assay><Baseline Surveys><Bioassay><Biological Assay><Case-Base Studies><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Characteristics><Child><Child Youth><Children (0-21)><Cohort Studies><Communities><Concurrent Studies><Data><Disease><Disorder><Epidemic><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology><Epidemiology Research><HIV><Home><Hour><Household><Human Immunodeficiency Viruses><Incidence><Infection><Intervention><Intervention Strategies><Interview><Investigation><Knowledge><LAV-HTLV-III><Life Cycle><Life Cycle Stages><Location><Long-term cohort study><Longitudinal cohort study><Longterm cohort study><Lymphadenopathy-Associated Virus><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Measurement><Measures><Methodology><Methods><Molecular Epidemiology><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Network Analysis><Network-based><Outcome><Pathway Analysis><Persons><Population><Prevalence><Research Infrastructure><Role><Rural><Rural Community><School-Age Population><Social Network><Socialization><Source><Structure><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><TB infection><Techniques><Television><Testing><Time><Transmission><Tuberculin Test><Tuberculosis><Uganda><Variant><Variation><Virus-HIV><Work><Youth><Youth 10-21><above age 65><adolescence (12-20)><adult youth><adulthood><after age 65><age 17 years><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated difference><age based difference><age correlated><age dependent><age dependent difference><age dependent variation><age difference><age group><age linked><age of 65 years onward><age related><age related difference><age related variation><age specific><age specific difference><age stratification><aged 65 and greater><aged 65+><aged ≥65><ages><burden of disease><burden of illness><case finding><case-controlled studies><cohort><density><design><designing><differ by age><difference across age><difference in age><disease burden><disseminated TB><disseminated tuberculosis><early childhood><epidemiologic><epidemiologic investigation><epidemiological><epidemiology study><homes><human old age (65+)><infection due to Mycobacterium tuberculosis><insight><intervention design><interventional strategy><juvenile><juvenile human><kids><life course><new approaches><novel><novel approaches><novel strategies><novel strategy><old age><over 65 years><population based><preference><prospective><rural area><rural location><rural region><scale up><school age><secondary analysis><seventeen year old><seventeen years of age><sex><social><social role><therapy design><transmission process><treatment design><tuberculin skin test><tuberculosis infection><tuberculous spondyloarthropathy><variation by age><young adult><young adulthood><youngster><≥65 years>