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Principal Investigator: LYLE G BEST
Organization: MISSOURI BREAKS RESEARCH, INC.
Fiscal Year: 2024
Award: $525,404
Funding agency: National Institute on Minority Health and Health Disparities
Title: FIPA2 M-PI: Best/Erdei/Torgerson
Project Summary
Pediatric asthma in American Indian (AI) communities of the Northern Plains Region presents a serious
health disparity. While many previous works carried out in minority communities – but not in AI children- looked
at individual level of influences on pediatric asthma and made parents responsible for asthma control, our
study will bring together a more comprehensive and realistic framework. Our novel approach will move the
study from the collected data toward Tribal health policy change. The FIPA2 study is designed to leverage the
previously NIMHD-funded Factors Influencing Pediatric Asthma study (U54MD008164) which successfully
enrolled 324 Cheyenne River Sioux Tribal (CRST) children (age 6-17 years) in 2013-2017. That study also had
a randomized educational clinical trial component (NCT 03302962) and we documented results of that work. In
the FIPA2 study, we will examine the complex interplay between social, environmental and immunological
response to viral respiratory infections an gap in knowledge that remains largely unknown. In this continued AI
community-focused pediatric asthma study, we will test the hypothesis that AI children with asthma have
alterations in immunological response to several viral respiratory infections as compared to those without
asthma. We will also investigate whether social and environmental factors (SEF) significantly contribute to this
disparity through stressed-induced modification of immune state. We will explore the role of viral respiratory
infections (RSV, rhinovirus C, and influenza A and B) and SEF on asthma severity, including frequency of
exacerbations, ER visits/hospitalizations, and use of asthma medications. Aim 1 will identify social and
environmental factors (SEF) that contribute to asthma susceptibility, severity and long-term respiratory health.
Participants will be enrolled at our Missouri Breaks Industries Research Inc. main office by working with
Reservation communities. To achieve enrollment goals, we will also enroll in Rapid City, SD, an urban setting
where AIs also located (12.4% of the city’s population). In Aim 2, we will examine the role of SEF on
immunological and clinical response to viral respiratory infections (VRIs) in AI children with and without
asthma. We will test our hypothesis that interactions with detailed survey measures of SEF with immunological
and clinical outcomes of VRIs, including seasonality of viral responses in participants with and without asthma
are the strongest and most significant predictors in our AI participants. Aim 3 will bring a comprehensive and
vivid community input to this study and will benefit from our local community advisory board (CAB) that
supports the study. We will rely on our own, experienced CBPR-based and bidirectional process evaluation.
We will create a feasible and community-driven asthma prevention framework that will be effective and can be
applied in other AI communities as well.
Terms: <0-11 years old><19S Gamma Globulin><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><7S Gamma Globulin><Active Follow-up><Adult><Adult Human><Affect><Age><Airway health><American Indian><American Indian community><American Indian reservation><American Indians><Area><Asthma><Asthma in Children><Atopic Allergy><Biological><Biological Markers><Blood Serum><Bronchial Asthma><Bronchiolitis><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 virus><COVID-19 years><COVID19 virus><Case-Base Studies><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Cheyenne><Child><Child Youth><Childhood Asthma><Children (0-21)><Cities><Clinical><Clinical Trials><CoV-2><CoV2><Communities><Complex><Data><Dedications><Development><Disease><Disorder><Disparities><Disparity><Drugs><ED visit><ER visit><Education><Educational aspects><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Enrollment><Environmental Factor><Environmental Risk Factor><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Frequencies><Funding><Gender><Goals><Grippe><Health Policy><High Prevalence><Hospital Admission><Hospitalization><Household><IgE><IgG><IgM><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Globulins><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunodeficiency and Immunosuppression Disorders><Immunoglobulin E><Immunoglobulin G><Immunoglobulin M><Immunoglobulins><Immunologic><Immunologic Diseases><Immunologic Factors><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological Factors><Immunological System Dysfunction><Immunological response><Immunologically><Immunologics><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Indian reservation><Individual><Industry><Infant><Inflammation><Influenza><Influenza A><Influenza A virus><Influenza B><Influenza B Virus><Influenza Viruses Type A><Influenza Viruses Type B><Influenzavirus A><Intervention><Intervention Strategies><Interview><Knowledge><Lakota><Lakota Sioux><Life><Link><Lower Respiratory Tract Infection><Lower respiratory infection><Measurement><Measures><Medication><Missouri><Modification><NCMHD><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><Non-Hispanic><Nonhispanic><Northern Plains><Not Hispanic or Latino><Orthomyxovirus Type A><Orthomyxoviruses Type B><Outcome><Parents><Participant><Pediatric asthma><Pharmaceutical Preparations><Policies><Population><Predisposition><Prevalence><Preventative measure><Preventative strategy><Prevention strategy><Preventive measure><Preventive strategy><Process><Questionnaires><RSV infection><Racial Group><Randomized><Recontacts><Research><Reservations><Respiratory Signs and Symptoms><Respiratory Syncytial Virus Infections><Respiratory syncytial virus><Rhinovirus><Risk><Role><Rural><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Seasons><Serology><Serum><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Severities><Sioux><Sioux Indians><Social Support System><South Dakota><Stress><Structure><Support System><Survey Instrument><Surveys><Susceptibility><Symptoms><Testing><Teton Sioux><Teton Sioux Indian><Tobacco smoke><Tribes><Type A Influenza><Upper Respiratory Infections><Upper Respiratory Tract Infection><Viral><Viral Diseases><Viral Respiratory Tract Infection><Virus Diseases><Work><Wuhan coronavirus><active followup><adulthood><adulthood transition><adverse childhood events><adverse childhood experiences><ages><airway symptom><asthma prevention><asthmatic><atopic triad><atopy><behavior influence><behavioral influence><bio-markers><biologic><biologic marker><biomarker><burden of infection><case-controlled studies><community advisory board><community advisory committee><community advisory panel><community engaged participatory research><community engaged research><community partnered research><community-engaged study><community-partnered study><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><cytokine><design><designing><developmental><disparity in health><drug/agent><enroll><environmental risk><ethnic subgroup><ethnicity group><experience><family support><follow up><follow-up><followed up><followup><hCoV19><health care policy><health disparity><healthcare policy><host response><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunologic substance><immunological substance><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><infection burden><interventional strategy><kids><member><minority communities><nCoV2><nation reservation><native american reservation><neglect><new approaches><novel approaches><novel strategies><novel strategy><offspring><parent><pathogen><process evaluation><racial population><racial subgroup><randomisation><randomization><randomly assigned><recruit><referral services><reservation community><respiratory><respiratory health><respiratory symptom><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sioux community><social><social factors><social influence><social role><social stress><socially stressed><stressor><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><tribal community><tribal health><tribal member><tribal reservation><urban environment><urban setting><viral infection><viral respiratory infection><virus infection><virus-induced disease><volunteer><youngster>