Infection and Rapid Transmission of SARS-C0V-2 in Ferrets

NIH Pandemic-Era Grants

Pandemic Era Grants

2020

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Principal Investigator: Jae U Jung
Organization: UNIVERSITY OF SOUTHERN CALIFORNIA
Fiscal Year: 2020
Award: $26,293
Funding agency: National Institute of Allergy and Infectious Diseases

Project Summary/Abstract
 The massive outbreak of newly emerged coronavirus disease 2019 (COVID-19) has been
rapidly spread worldwide, leading to a pandemic infection and serious global health emergency. In
order to prevent further dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), understanding the in vivo characteristics of viral infection and transmission is of high priority.
Specifically, an animal model that recapitulates the COVID-19 clinical symptoms in human infection
is urgently needed in order to decipher the transmission routes and pathobiology of this virus and
ultimately allow testing of pharmaceutical interventions. With our expertise in the development of
animal model, we have recently established a ferret model for SARS-CoV-2 infection and
transmission that highly recapitulates aspects of the human infection. The main goal of this study is
to comprehensively characterize ferret animal model for SARS-CoV-2 infection, transmission and
pathogenesis for vaccine interventions.

Terms: <2019 novel coronavirus><2019-nCoV><4 year old><4 years of age><Age><Animal Model><Animal Models and Related Studies><Basic Research><Basic Science><Biochemical><Blood Serum><Body Temperature><COVID-19><COVID19><Characteristics><Clinical><Coughing><Differential Display><Disease Outbreaks><Epithelial Cells><Exhibits><Feces><Ferrets><Ferritin><Genes><Genetic><Genotype><Goals><Human><Immune Evasion><Immunity><In Vitro><Infection><Intervention><Intervention Strategies><Length><Lung><Lung Respiratory System><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Nanotechnology><Nasal><Nasal Passages Nose><Non-structural Protein><Nonstructural Protein><Nose><Outbreaks><Pathogenesis><Pathogenicity><Patients><Permeability><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Proteins><Recombinants><Reproducibility><Research Specimen><Respiratory System, Nose, Nasal Passages><Role><Route><SARS><SARS coronavirus disease><SARS-CoV disease><SARS-CoV-2><SARS-CoV2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related coronavirus 2><Safety><Saliva><Sampling><Serum><Severe Acute Respiratory Syndrome><Severe Acute Respiratory Syndrome CoV disease><Severe Acute Respiratory Syndrome coronavirus disease><Severe Fever with Thrombocytopenia Syndrome Virus><Severe acute respiratory syndrome coronavirus 2><Severity of illness><Specimen><Structure><Subunit Vaccines><Surface><Symptoms><Testing><Thrombocytopenia><Thrombopenia><Time><Transgenic Organisms><Transmission><Urine><Urine Urinary System><Vaccine Design><Vaccines><Viral><Viral Diseases><Viral Shedding><Virus><Virus Diseases><Virus Shedding><Wuhan coronavirus><acute bronchiolitis><adult youth><age 4 years><aged><ages><animal model development><chronic infection><corona virus disease 2019><coronavirus disease 2019><differential display technique><disease severity><elderly patient><four year old><four years of age><global health emergency><immunogenicity><in vivo><interventional strategy><mRNA Differential Displays><model of animal><model organism><mortality><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><older patient><pandemic><pandemic disease><parent grant><persistent infection><prevent><preventing><pulmonary><receptor binding><receptor bound><social role><stool><therapeutic agent development><therapeutic development><transgenic><transmission process><vaccine candidate><viral RNA><viral infection><viral transmission><virus RNA><virus infection><virus transmission><virus-induced disease><young adult><young adulthood>