Document text
Principal Investigator: Grace C. John-Stewart
Organization: UNIVERSITY OF WASHINGTON
Fiscal Year: 2023
Award: $298,428
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Abstract
Globally, the number of HIV-exposed uninfected (HEU) children/adolescents is growing, with 1.2 million HEU
infants born annually1. There is evidence that HEU children have increased morbidity and mortality, and lower
neurocognitive scores than their HIV-unexposed (HUU) counterparts. The parent HOPE study (NICHD
R33103079) has been designed to compare neurodevelopmental outcomes between HEU and HUU children
from 6-weeks of age to 3 years in a longitudinal cohort and to assess longer term effects in a multi-site cross-
sectional age-stratified cohort. The HOPE study will assess influence of maternal viral load, ART timing, and
regimen on HEU outcomes, and explore whether HEU neurodevelopmental outcomes are associated with
telomere length (TL).
Administrative Supplement: This supplement application falls within the scope of work of the parent
application. The parent grant scope of work included assessment of cofactors that influence HEU/HUU
neurodevelopmental outcomes including psychosocial, telomere length, and infectious diseases. In this
Administrative Supplement proposal, we request funding for:
• Goal 1. To characterize family structures and explore the roles of parental caregiving (including paternal
perspectives) in child neurodevelopmental outcomes in HEU and HUU using participatory visual qualitative
methods. Qualitative data will complement extensive quantitative data from the cohort of 1000 HEU and
1000 HUU in understanding how caregiver structure influences neurodevelopmental outcomes in both
groups of children.
• Goal 2. To conduct maternal telomere assays (parent budget supports infant telomere assays) and use this
data to better characterize cofactors of infant telomere length (TL). Maternal TL assays [already approved
by KNH and UW ethical committees] are a key predictor of infant TL).
• Goal 3. To conduct SARS-CoV2 antibody testing [already approved by UW Human Subjects Division] on
infant dried blood spots [DBS] already collected at 6 weeks and 1, 2, 3 years) to assess impact of maternal
peripartum SARS-COV2 on already measured longitudinal infant neurodevelopmental outcomes.
These goals leverage the unique HOPE cohort and enable more comprehensive assessment of critical
determinants of child neurodevelopment.
Terms: <0-11 years old><12-20 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><3 year old><3 years of age><AD/HD><ADHD><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Administrative Supplement><Adolescence><Adolescent><Adolescent Youth><Advocate><Age><Anxiety><Assay><Attention deficit hyperactivity disorder><Bioassay><Biologic Assays><Biological Assay><Biological Markers><Blood><Blood Reticuloendothelial System><Budgets><COVID-19 antibody><COVID-19 infection><COVID-19 virus><COVID-19 virus infection><COVID19 infection><COVID19 virus><Care Givers><Caregivers><Caring><Child><Child Youth><Childhood><Children (0-21)><Clinic><CoV-2><CoV2><Collaborations><Communicable Diseases><Complement><Complement Proteins><Computerized Medical Record><Data><Development><Dryness><Early Intervention><Electronic Medical Record><Enrollment><Ethics><Evaluation><Family><Funding><Future><Generalized Growth><Goals><Growth><Guidelines><HIV><HIV-exposed uninfected infant><Hearing><Human Immunodeficiency Viruses><Infant><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Inflammation><Intervention><Intervention Strategies><Kenya><LAV-HTLV-III><Length><Long-term cohort><Longitudinal cohort><Longterm cohort><Lymphadenopathy-Associated Virus><Measures><Mental Depression><Mental Health><Mental Hygiene><Morbidity><Morbidity - disease rate><NICHD><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><Neural Development><Neurocognitive><Outcome><Parents><Perinatal><Peripartum><Phase><Policies><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Psychological Health><Qualitative Methods><Qualitative Research><Regimen><Research Methodology><Research Methods><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 antibody><SARS-CoV-2 infection><SARS-CoV2><SARS-CoV2 antibody><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Screening procedure><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome related corona virus 2><Site><Spottings><Structure><Testing><Tissue Growth><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Visual><Work><Wuhan coronavirus><active followup><adolescence (12-20)><age 3 years><age stratification><ages><anti-retroviral therapy><anti-retroviral treatment><antibody against COVID-19><antibody against SARS-CoV-2><antibody against SARS-CoV2><antibody against coronavirus disease 2019><antibody against severe acute respiratory syndrome coronavirus 2><antibody to COVID-19><antibody to SARS-CoV-2><antibody to SARS-CoV2><antibody to coronavirus disease 2019><antibody to severe acute respiratory syndrome coronavirus 2><antiretroviral therapy><antiretroviral treatment><bio-markers><biologic marker><biomarker><care giving><caregiving><cofactor><cohort><coronavirus disease 2019 antibody><coronavirus disease 2019 infection><coronavirus disease 2019 virus><coronavirus disease-19 virus><cost estimate><cost estimation><depression><design><designing><developmental><efavirenz><enroll><ethical><falls><family influence><family structure><fetal><follow up><follow-up><followed up><followup><hCoV19><human subject><improved><infancy><infantile><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><insight><interventional strategy><juvenile><juvenile human><kids><mortality><nCoV2><neurodevelopment><ontogeny><parent><parent grant><parent role><parental role><pediatric><programs><psychosocial><qualitative reasoning><research and methods><screening><screening tools><screenings><severe acute respiratory syndrome coronavirus 2 antibody><social culture><socio-cultural><sociocultural><telomere><three year old><three years of age><tool><youngster>