Immunoengineering
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Principal Investigator: Kaitlyn Sadtler Organization: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING Fiscal Year: 2024 Award: $873,333 Funding agency: National Institute of Biomedical Imaging and Bioengineering Finalizing SARS-CoV-2 Research We are finalizing the publication of our last works on COVID19 research which have all completed experimentation and are being prepared for submission to scientific journals. Please refer to prior report regarding COVID19 research projects. Biomaterials and Immunoengineering In FY 2024 the Section on Immunoengineering continued our work on immunology in the context of tissue regeneration after traumatic injury. We published five primary research articles on our findings including 1 paper in Nature Materials in which we describe an immune cell type and pathway that have not previously been implicated in wound healing and tissue regeneration that is tied to autoimmunity and may providing an interesting link between traumatic injury and tissue damage associated with autoimmune responses. We also published on the intersection of autoimmunity, metabolism, and wound healing in mouse models using the MRL/MpJ mouse, which in wound healing literature is known as a “super healer” mouse while in autoimmunity field it is known as an autoimmune-prone mouse. This builds off of our previous published works. We also showed tissue location specific roles in shaping immune responses to biomaterial implantation and investigated early responders to injury and biomaterial implantation (eosinophils). We began some of our in vitro work and in our first publication here, showed differential fibrosis models with a research manuscript focusing on the deposition of collagen in vitro and different methods used for this approach. We are in the process of launching collaborations and continuing collaborations with outside trauma centers to better facilitate our human research and bring in data from other wound models (like pigs) that are not done at NIH. Terms: <2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Autoimmune><Autoimmune Responses><Autoimmune Status><Autoimmunity><Biocompatible Materials><Biomaterials><Blood Eosinophil><Body Tissues><COVID-19><COVID-19 virus><COVID19 virus><CV-19><CoV-2><CoV2><Collaborations><Collagen><Communities><Coronavirus Infectious Disease 2019><Data><Deposit><Deposition><Eosinophilic Granulocyte><Eosinophilic Leukocyte><Family suidae><Fibrosis><Foreign Bodies><Human><Immune><Immune response><Immunes><Immunological response><Immunology><In Vitro><Injury><Intermediary Metabolism><Journals><Link><Literature><Location><MRL/MpJ Mouse><Magazine><Manuscripts><Marrow Eosinophil><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Muscle><Muscle Tissue><NIH><National Institutes of Health><Natural regeneration><Nature><Paper><Pathway interactions><Pigs><Process><Publications><Publishing><R-Series Research Projects><R01 Mechanism><R01 Program><Regeneration><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Scientific Publication><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Shapes><Suidae><Swine><Tissues><Trauma><Traumatic injury><United States National Institutes of Health><Work><Wound Repair><Wound models><Wuhan coronavirus><biological material><cell type><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><engineered immune system><eosinophil><hCoV19><host response><immune engineering><immune system response><immunoengineering><immunoresponse><implantation><injuries><mouse model><murine model><muscular><nCoV2><pathway><porcine><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><response><social role><suid><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><trauma centers><wound healing><wound healing models><wound recovery><wound resolution>