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Principal Investigator: Viviana A Simon
Organization: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Fiscal Year: 2024
Award: $253,500
Funding agency: National Institute of Allergy and Infectious Diseases
The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for
better understanding of the mechanisms controlling broadly protective immune responses and generating
vaccine candidates able to elicit such responses. The program project entitled “Programming Long-lasting
Immunity to Coronaviruses (PLUTO)” proposes a comprehensive research plan towards designing pan-
sarbecovirus and pan-betacoronavirus vaccines with broad protection by applying in-depth B cell
characterization in the context of coronavirus immune histories imprinted by successive vaccinations
and/or infections. Two complementary research projects will establish correlates of robust, durable
and protective coronavirus humoral immunity (Project 1) as well as design and test efficacy of viral
variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. The Administrative Core led by one of
the two Principal Investigators, Dr. Viviana Simon, will function as a coordinating hub of the program
providing a strong overall administrative infrastructure. The proposed activities and services of the
Administrative Core are to provide overall management and program coordination, to facilitate
communication within the program, to monitor progress within the projects and to prioritize, allocate, and
manage resources. It will also support cooperation between the Research Projects and Service Cores by
putting in place transfer agreements, data management plans and conflict resolution procedures. The
Antibody Core will develop a large panel of recombinant monoclonal antibodies (mAbs) against coronavirus
spike proteins to aid in defining specificity of immune responses elicited by coronavirus infection and/or
vaccination in humans and animal models. The Animal Model Core will provide a central resource with
approvals, facilities, and expertise to assess efficacy of broadly cross-reactive coronavirus antibodies and
vaccines in robust pre-clinical models against a spectrum of coronaviruses, including Select Agents. A
multidisciplinary team of scientists from five institutions who have an outstanding track record of working
collaboratively will conduct the proposed studies. The Research Projects will collaborate across
projects and with the Antibody and Animal Model Cores, coordinated by the Administrative
Core. The integrated and synergistic activities across Projects and Cores will drive successful
completion of the program project's ambitious research agenda, enabling achievement of the long-term
PLUTO goal of developing variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. These
findings will contribute to curbing the current SARS-CoV-2 pandemic and mitigate the risk of future
pandemics with coronaviruses.
Terms: <Achievement><Achievement Attainment><Administrative Management><Animal Model><Animal Models and Related Studies><Antibodies><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><BetaCoV vaccine><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Clinical Treatment Moab><CoV S protein><CoV glycoprotein S><CoV spike glycoprotein><CoV spike protein><Collaborations><Communication><Coronaviridae><Coronaviridae Infections><Coronavirus><Coronavirus Infections><Coronavirus glycoprotein S><Coronavirus spike protein><Data><Data Bases><Databases><Decision Making><Ensure><Environment><Evaluation><Financial Management><Goals><History><Humoral Immunities><Immune><Immune response><Immunes><Immunity><Immunological response><Immunologist><Infection><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Laboratories><Leadership><Manuscripts><Monitor><Monoclonal Antibodies><Multidisciplinary Collaboration><Multidisciplinary Research><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Occupational activity of managing finances><Office of Administrative Management><Pennsylvania><Performance><Philadelphia><Physicians><Policies><Pre-Clinical Model><Preclinical Models><Preparation><Principal Investigator><Procedures><Progress Reports><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Reagent><Recombinants><Recording of previous events><Reporting><Research><Research Grants><Research Institute><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resource Allocation><Resource Sharing><Resources><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Sarbecovirus><Scientist><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Specificity><Strategic Planning><Structural Biologist><Transfer Agreement><United States National Institutes of Health><Universities><Vaccination><Vaccines><Variant><Variation><Viral><Washington><antibody-based immunity><beta coronavirus vaccine><betacoronavirus vaccine><conference><conflict resolution><convention><corona virus><coronavirus S protein><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus of pandemic concern><coronavirus of pandemic potential><coronavirus spike glycoprotein><coronavirus vaccination><coronavirus with pandemic potential><cost><cross reactivity><dashboard><data access><data base><data harmonization><data management><data quality><design><designing><determine efficacy><develop a vaccine><develop vaccines><development of a vaccine><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><flexibility><flexible><future pandemic><harmonized data><histories><host response><human model><immune system response><immunoresponse><imprint><mAbs><material transfer agreement><medical college><medical schools><meeting><meetings><model of animal><model of human><monoclonal Abs><multidisciplinary><next pandemic><panbetaCoV vaccine><pandemic coronavirus><pandemic threat coronavirus><preparations><programs><quality assurance><response><risk mitigation><school of medicine><seasonal coronavirus><seasonal human coronavirus><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social media><summit><symposia><symposium><synergism><vaccination against coronavirus><vaccine candidate><vaccine development><vaccines against betacoronaviruses><vaccines targeting the betacoronavirus><ward><web page><webpage><zoonotic CoV><zoonotic coronavirus><β coronavirus vaccine>