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Principal Investigator: Deborah Hall Bennett
Organization: UNIVERSITY OF CALIFORNIA AT DAVIS
Fiscal Year: 2024
Award: $1,109,470
Funding agency: NIH Office of the Director
Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new
Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed
close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into
ECHO from three neurodevelopmental groups of children with: autism spectrum disorder (ASD),
developmental delays (DD) without autistic symptoms, and typical development (TD); uploaded
over 55,000 data collection forms to the ECHO Cohort Data Platform, and transferred over 8000
biospecimen aliquots to the ECHO Biorepository, including DNA for SNP arrays, urine for
analyzing novel chemicals from common but understudied household products, and blood for
multiple uses. The UC Davis ECHO team led a number of analysis proposals,
authored/coauthored 40 peer-reviewed papers, with another 50 in-progress. The Team also
contributed to developing ECHO policies and participated in and led various working groups,
such as Neurodevelopment, Chemical Exposures, Epigenetics, as well as Committees on
Publications, Policy Implementation and Evaluation, and others. The ECHO-ReCHARGE cohort
focuses on the ECHO area of neurodevelopment, which is facilitated by the UC Davis MIND
Institute. In ECHO Phase 2, the UC Davis Aim 1 will: examine environmental exposures
including air pollution, greenspace, and home product use; as well as family financial hardship
and parental mental health or substance use problems, in associations with externalizing and
internalizing behaviors, namely, symptoms of ADHD, anxiety and depression at ages 8-20; and
potential modification of exposure-outcome associations by early childhood developmental
diagnosis (ASD, DD, TD), age, sex and puberty status. Aim 2 will evaluate the environmental
exposures listed above along with childhood exposure to PFAS and plasticizers, for
associations with longitudinal trajectories of the above behavioral and emotional outcomes, as
well as cognitive skills. Aim 3 will implement the final ECHO protocol with high fidelity, maximize
retention, and adhere to all ECHO policies, IRB, HIPAA and other regulations. UC Davis will
continue to contribute broadly to the ECHO infrastructure; advance the science through analysis
and publications; work to retain participants; and actively participate and play leadership roles in
this high-profile, unique program to discover underlying risk and resilience factors for childhood health and development.
Terms: <0-11 years old><12-20 years old><6-11 years old><AD/HD><ADHD><ASD><Active Follow-up><Address><Adolescence><Adolescent><Adolescent Youth><Affect><Affective><Age><Air Pollution><Aliquot><Anxiety><Area><Attention><Attention deficit hyperactivity disorder><Attentional deficit><Autism><Autistic Disorder><Behavior><Behavioral><Biologic Factor><Biological><Biological Factors><Black><Black race><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Cell Differentiation><Cell Differentiation process><Characteristics><Charge><Chemical Exposure><Chemicals><Child><Child Health><Child Youth><Childhood><Children (0-21)><Cognition><Cognitive><Cognitive deficits><Collection><Consultations><DNA><Data><Data Collection><Deoxyribonucleic Acid><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Diagnostic Factor><Early Infantile Autism><Emotional><Emotional Depression><Emotions><Encephalon><Enrollment><Environment><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Evaluation><Exposure to><Exposure to Pb2+><Family><Fetal health><Financial Hardship><Funding><Glia><Glial Cells><Goals><Green space><HIPAA><Happiness><Health><Health Insurance Portability and Accountability Act><Hispanic><Home><Household><Household Products><Household Supplies><Hyperactivity><IRB><IRBs><Impairment><Impulsivity><Indigenous><Individual><Infantile Autism><Influentials><Infrastructure><Institutional Review Boards><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Intervention Strategies><Irritable Mood><Jobs><Kanner's Syndrome><Kennedy Kassebaum Act><Knowledge><Kolliker's reticulum><Leadership><Life><Link><Measures><Mental Depression><Mental Health><Mental Hygiene><Modification><Moods><Neighborhoods><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Neurosciences><Non-neuronal cell><Nonneuronal cell><Occupations><Outcome><Outcome Measure><PFAS><PL 104-191><PL104-191><Paper><Parents><Participant><Pattern><Pb exposed><Pb exposure><Pb2+ Exposure><Pb2+ exposed><Pediatric cohort><Peer Review><Pesticides><Phase><Plasticizers><Play><Policies><Poly-fluoroalkyl substances><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Process><Productivity><Professional Positions><Protocol><Protocols documentation><Psychological Health><Puberty><Public Health><Public Law 104-191><Publications><Race><Races><Racial Group><Radiation><Regulation><Research><Research Resources><Resources><Risk><Risk Factors><Role><SNP array><SNP chip><Schools><Science><Scientific Publication><Site><Social Justice><Specific Child Development Disorders><Subgroup><Symptoms><Syndrome><System><Time><United States Health Insurance Portability and Accountability Act><Urine><Visit><Work><Youth><Youth 10-21><active followup><adolescence (12-20)><adolescent health><ages><anxiety symptoms><anxious symptom><attentive deficit><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><biobank><biologic><biorepository><cellular differentiation><cognitive defects><cognitive function><cognitive skill><cohort><consultation><data driven platform><data platform><depression><depression symptom><depressive><depressive symptoms><developmental><diversity and equity><early childhood><enroll><environmental justice><environmental risk><environmental stresses><environmental stressor><epigenetically><ethnic subgroup><ethnicity group><experience><exposed to lead><exposure to Pb><exposure to lead><falls><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><follow up><follow-up><followed up><followup><greenspace><high risk><homes><improved><inattention><inattentiveness><indexing><intellectual and developmental disability><intervention design><interventional strategy><juvenile><juvenile human><kids><lead exposed><lead exposure><limited intellectual functioning><longitudinal design><measurable outcome><middle childhood><multi-racial><multiracial><myelination><nerve cement><neurodevelopment><neuronal><novel><outcome measurement><parent><pediatric><peer><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><phthalates><polyfluorinated alkyl substances><polyfluoroalkyl substances><postnatal><prenatal><prognostic><programs><racial><racial background><racial origin><racial population><racial subgroup><resilience factor><resiliency factor><retention rate><retention strategy><sex><single nucleotide polymorphism array><single nucleotide polymorphism chip><social><social factors><social role><social stresses><social stressor><stressor><substance use><substance using><synapse formation><synaptogenesis><therapy design><treatment design><unborn><work group><working group><youngster>