Document text
Principal Investigator: Fiona C Baker
Organization: SRI INTERNATIONAL
Fiscal Year: 2024
Award: $658,480
Funding agency: National Institute on Alcohol Abuse and Alcoholism
PROJECT SUMMARY / ABSTRACT
Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns,
increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood.
In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium
on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a
diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21
years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93%
retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state
fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer
and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep
and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient
or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories
and functional concomitants.
NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A
will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on
subsequent developmental trajectories of cognitive performance, brain structure and function, and
psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which
alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3
will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age
of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the
impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations
with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of
alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to
which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect,
sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge
alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol
use on the brain, and sex-differentiating psychosocial factors will be tested.
With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel
information to the public on the enduring and transient effects of adolescent drinking on adult functioning by
discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.
Terms: <12-20 years old><21 year old><21 years of age><21+ years old><Abstinence><Acceleration><Active Follow-up><Acute><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Adverse effects><Affect><Affective><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Behavioral><Biological><Brain><Brain Nervous System><COVID-19 affected><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><Cardiac Chronotropism><Clinical><Cognition><Cognitive><Communities><Computers><Data><Development><Differences between sexes><Differs between sexes><Distress><Dose><Economics><Elements><Emotional><Encephalon><EtOH abuse><EtOH drinking><EtOH use><Event><Family><Female><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Generalized Growth><Goals><Growth><Health><Heart Rate><Heavy Drinking><History><Home><Impairment><Individual><International><Learning><Life><Life Stress><Link><Longitudinal Studies><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory><Mission><Modeling><Monitor><NMR Imaging><NMR Tomography><Neural Development><Nuclear Magnetic Resonance Imaging><Outcome><Outcome Measure><Patient Recruitments><Pattern><Personal Satisfaction><Persons><Physical activity><Polysomnography><Position><Positioning Attribute><Process><Protocol><Protocols documentation><Psychopathology><Psychosocial Factor><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Recording of previous events><Recovery><Research Grants><Research Project Grants><Research Projects><Rest><Risk><Risk Factors><Sampling><Schools><Sex Differences><Sex Differentiation><Sexual differences><Site><Sleep><Sleep Monitoring><Sleep disturbances><Somnography><Specialty><Specific qualifier value><Specified><Stress><Structure><Symptoms><System><Technology><Testing><Tissue Growth><Work><Youth Drinking><Zeugmatography><aberrant sleep><abnormal psychology><active followup><adolescence (12-20)><adolescent alcohol binge exposure><adolescent alcohol co-use><adolescent alcohol consumption><adolescent alcohol drinking><adolescent alcohol intake><adolescent alcohol use><adolescent binge alcohol drinking><adolescent binge drinking><adolescent drinking><adolescent onset binge drinking><adulthood><age 21><age 21 years><ages><alcohol co-abuse><alcohol cue><alcohol during adolescence><alcohol effect><alcohol expectancy><alcohol ingestion><alcohol initiation><alcohol intake><alcohol intake among adolescents><alcohol problem><alcohol product use><alcohol related cue><alcohol use><alcohol use among adolescents><alcohol use disorder><alcohol use during adolescence><alcohol use in adolescence><alcohol use in adolescents><alcohol use initiation><alcoholic beverage consumption><alcoholic drink intake><binge alcohol consumption><binge drinking><biologic><cardiac function><cognitive control><cognitive performance><cohort><coronavirus disease 2019 consequence><coronavirus disease 2019 effect><coronavirus disease 2019 impact><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><coronavirus disease-19 impact><cue reactivity><design><designing><developmental><disrupted sleep><disturbed sleep><drink heavily><drinking><drinking during adolescence><drinking in adolescent><drinking initiation><drinking onset><early adulthood><early onset><economic><effects following the COVID-19 pandemic><emerging adult><emerging adulthood><episodic drinking><ethanol abuse><ethanol consumption><ethanol cue><ethanol drinking><ethanol during adolescence><ethanol effect><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experience><externalizing behavior><extreme drinking><fMRI><follow up><follow-up><followed up><followup><function of the heart><gray matter><hazardous alcohol use><heart function><heavy alcohol use><histories><homes><impact of the SARS-CoV-2 pandemic><impaired sleep><improved><information processing><irregular sleep><juvenile><juvenile human><long-term study><longitudinal outcome studies><longterm study><machine based learning><male><malleable risk><measurable outcome><medical specialties><mobile app><mobile application><mobile device application><modifiable risk><multi-modal neuro-imaging><multi-modal neuroimaging><multimodal neuro-imaging><multimodal neuroimaging><neural><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neurological imaging><neuropsychiatric><neuropsychiatry><novel><ontogeny><outcome measurement><pandemic><pandemic disease><participant recruitment><polysomnographic><post-pandemic><pre-pandemic><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><psychosocial variables><recruit><response><retention rate><retention strategy><sex based differences><sex-dependent differences><sex-differentiation><sex-related differences><sex-specific differences><sexual differentiation><sleep disruption><sleep dysregulation><sleep measurement><sleep polysomnography><social><substantia grisea><teen drinking><teenage alcohol use><teenage drinking><teenager alcohol use><twenty-one year old><twenty-one years of age><under age alcohol consumption><under age alcohol use><underage alcohol consumption><underage alcohol use><underage drinking><well-being><wellbeing><youth alcohol co-use><youth alcohol consumption><youth alcohol use>