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Principal Investigator: Lorelei Mucci
Organization: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
Fiscal Year: 2024
Award: $1,405,685
Funding agency: National Cancer Institute
The goal of this competing renewal application is to support the core infrastructure and follow-up of the Health
Professionals Follow-up Study (HPFS), a cancer epidemiology cohort of 51,529 U.S. male health professionals
age 40 to 75 years at baseline in 1986. This cohort is unique in its focus on men’s health and with 35 years
follow-up, provides a time frame essential to study modifiable risk factors for cancer incidence with realistic
latencies. Information has been regularly updated on diet, physical activity, smoking, weight, medications, and
other potentially modifiable determinants of cancer risk. The biorepository is key element of the cohort and
includes DNA, red blood cells, plasma, stool, and toenails. Tumor tissue has been obtained from 7,522 incident
cancers of the prostate, colon, bladder, kidney, and lung (nonsmokers), and hematologic cancers. Cohort
follow-up is consistently 90% at each two-year cycle and mortality follow-up is virtually complete. At present,
21,853 participants are living and at a heightened age of cancer incidence; these will be the most informative
cases given extensive exposure data since midlife. In the current grant, 492 papers were published that utilize
data and/or biological samples from HPFS; 317 of these specifically examined cancer or precursor outcomes
including >100 led by external investigators. To date, 17,091 participants have been diagnosed with cancer
and 4,704 cancer deaths have occurred; 7,061 men are currently living with a cancer diagnosis.
In the next funding cycle, we propose the following aims: Aim 1. To actively follow-up for cancer
incidence and mortality; to update exposures pre- and post-diagnosis of cancer; Aim 2. To collect data on
quality of life, treatment, progression, and cannabis use among cancer survivors. Aim 3. To update the food
composition and nutrient databases that support the HPFS and external studies; to jointly calibrate dietary
questionnaires with the Southern Community Cohort Study (SCCS) to support combined studies. Aim 4. To
maintain and expand the HPFS tissue biorepository to collect tissue from prostate, colon, lung, kidney, and
bladder cancers; to pilot artificial intelligence approaches to characterize morphologic features of prostate
tumors. Aim 5. To maintain other biorepositories including plasma, red blood cells, toenails, and germline
DNA. Aim 6. To expand linkage of geocoded addresses of HPFS and SCCS participants to assess longitudinal
measures of the built environment and neighborhood SES over three decades. Aim 7. To maintain and
augment the statistical infrastructure and data management to support HPFS analyses by internal and external
investigators; to develop new software to facilitate latency and competing risk analyses in HPFS and share
with external investigators. Aim 8. To facilitate resource sharing and collaborations with external investigators
and consortia, including the transfer of HPFS questionnaire datafiles onto a secure cloud environment. With
additional follow-up, including after cancer diagnosis, the HPFS remains ideally positioned to make innovative
contributions to our goal of reducing cancer burden by identifying primary and secondary prevention strategies.
Terms: <65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AI based method><AI system><Active Follow-up><Address><African American><Afro American><Afroamerican><Age><Aged 65 and Over><Alternative Therapies><Alternative intervention><Archives><Artificial Intelligence><Biological><Biological Markers><Bladder Cancer><Blood Plasma><Blood erythrocyte><Body Tissues><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Calibration><Cancer Burden><Cancer Cause><Cancer Etiology><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Cessation of life><Cohort Analyses><Cohort Analysis><Cohort Studies><Collaborations><Colon Cancer><Colon Carcinoma><Communities><Computer Reasoning><Computer software><Concurrent Studies><DNA><Data><Data Bases><Data Files><Data Management Resources><Data Management System><Databases><Death><Death Rate><Deoxyribonucleic Acid><Diagnosis><Diet><Dietary Assessment><Dietary Questionnaires><Differences between sexes><Differs between sexes><Disease Progression><Drugs><Elements><Environment><Environmental Exposure><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Erythrocytes><Erythrocytic><Feces><Follow-Up Studies><Followup Studies><Food><Frequencies><Funding><Germ Lines><Goals><Grant><H and E><Health><Health Care Professional><Health Professional><Health Resources><Healthcare professional><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematoxylin and Eosin><Hematoxylin and Eosin Staining Method><Incidence><Infrastructure><Investigators><Kidney Cancer><Kidney Carcinoma><Laboratories><Link><Machine Intelligence><Malignant Bladder Neoplasm><Malignant Hematologic Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Bladder><Malignant Tumor of the Lung><Malignant Tumor of the Prostate><Malignant neoplasm of lung><Malignant neoplasm of prostate><Malignant neoplasm of urinary bladder><Malignant prostatic tumor><Marrow erythrocyte><Measures><Medication><Mental Health><Mental Hygiene><Methods><Modeling><Molecular Epidemiology><Morbidity><Morbidity - disease rate><Morphology><National Cancer Burden><Neighborhoods><Newly Diagnosed><Nucleic Acids><Nurses' Health Study><Nutrient><Outcome><Paper><Participant><Pharmaceutical Preparations><Physical activity><Plasma><Plasma Serum><Position><Positioning Attribute><Preventative strategy><Prevention strategy><Preventive strategy><Primary Prevention><Productivity><Prostate CA><Prostate Cancer><Prostate Neoplasms><Prostate Tumor><Prostate malignancy><Prostatic Cancer><Prostatic Neoplasia><Prostatic Neoplasms><Psychological Health><Publications><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><Questionnaires><Red Blood Cells><Red Cell><Renal Cancer><Renal Carcinoma><Research><Research Personnel><Research Resources><Research Specimen><Researchers><Resource Sharing><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Running><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Scientific Publication><Secondary Prevention><Secure><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sex Differences><Sexual differences><Slide><Smoking><Social Support System><Socio-economic status><Socioeconomic Status><Software><Specimen><Structure of nail of toe><Support System><Systems Analyses><Systems Analysis><THC co-use><THC use><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Tissue Arrays><Tissue Banks><Tissue Chip><Tissue Collection><Tissue Microarray><Tissue repository><Tissues><Toe Nail><Toenail><Tumor Tissue><Update><Urinary Bladder Cancer><Urinary Bladder Malignant Tumor><Weight><above age 65><active followup><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><anti-cancer therapy><artificial intelligence method><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><blood corpuscles><built environment><cancer diagnosis><cancer epidemiology><cancer in the colon><cancer risk><cancer therapy><cancer-directed therapy><cannabis use><cohort><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data base><data dictionary><data management><data sharing><dietary><diets><drug/agent><epidemiologic investigation><epidemiology study><follow up><follow-up><followed up><followup><genetic epidemiologic study><genetic epidemiology><human old age (65+)><indexing><innovate><innovation><innovative><life-style factor><lifestyle factors><lung cancer><male health><malignancy><malleable risk><marijuana use><member><men><men's health><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><mortality><mortality rate><mortality ratio><neoplasm/cancer><non-smoker><nonsmoker><novel><old age><over 65 years><pandemic><pandemic disease><physical conditioning><physical health><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><socio-economic position><socioeconomic position><stool><user-friendly><virtual><weights><≥65 years>